Determination of polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue by large-volume injection-narrow-bore capillary gas chromatography/electron impact low-resolution mass spectrometry

A new analytical method has been developed for the quantification of polybrominated diphenyl ethers (PBDEs) in human adipose tissue samples. After Soxhlet extraction and a cleanup procedure using two successive solid-phase extraction cartridges containing acid silica and acid silica: neutral silica:deactivated basic alumina (from top to bottom), detection can been achieved by narrow-bore (0.10-mm i.d.) capillary gas chromatography/electron impact low-resolution mass spectrometry using a large-volume injection technique. Using narrow-bore capillaries, it is possible to analyze complex mixtures in a short time (up to 10 min), saving 50% or more of the analysis time of conventional columns while maintaining a similar resolution power. The method allows the determination of five major PBDE congeners (BDE 28, 47, 99, 100, and 153) at concentrations below 1 ng/g lipid weight. Detection limits in the selected ion mode varied between 0.05 and 0.30 ng/g lipid weight, depending on the degree of bromination. The sensitivity of this method can compete with low-resolution mass spectrometry with electron capture ionization, while a much better selectivity is obtained. Levels of PBDEs in 20 Belgian human adipose tissue samples ranged between 2.18 and 11.70 ng/g lipid weight and were similar to previously reported values from Europe.     

Physical modelling of solute transport in porous media: evaluation of an imaging technique using UV excited fluorescent dye

The development and evaluation of a 2-dimensional physical model, which is designed to assist in the characterisation of complex solute transport problems in porous media, is described. The laboratory model is a transparent 2-dimensional porous media of nominal thickness and uses a non-invasive imaging technique in conjunction with a fluorescent dye tracer (sodium fluorescein) to monitor solute movements. Under ultraviolet (UV) illumination the dye emits visible light which is imaged by a CCD (Charge Coupled Device) camera. The image is processed to estimate the 2-dimensional distribution of tracer concentrations. The system can successfully model a simple contaminant plume within a homogenous porous matrix constructed from glass beads (60-100 microm). Experimental results show that transverse dispersion coefficient was 3.9 x 10(-10) m2/s when sodium fluorescein transported in porous matrix with a walter velocity of 5.71 x 10(-6) m/s. The low transverse dispersion coefficient suggests that the molecular diffusion of solute cannot be neglected under low velocity of the water. The advantages of using UV rather than an ordinary light system are a reduction in noise and experimental errors. Errors due to light dispersion within the model are shown to be negligible for the current model. Since contaminant with aromatic rings are usually fluorescent and biological samples can be labelled by fluorescent dye, this imaging technique using UV excited fluorescent dye will be used to investigate biodegradation process in porous media.     

Semantic memory in Alzheimer's disease and the frontotemporal dementias: A longitudinal study of 236 patients.

Using semantic dementia (SD) as a reference point, the authors assessed semantic memory in four other neurodegenerative disorders: progressive nonfluent aphasia (PNFA), frontal variant frontotemporal dementia (fvFTD), Alzheimer's disease (AD), and posterior cortical atrophy (PCA). Individuals with SD were more impaired than other groups on semantic measures and showed a characteristic pattern across tasks: category fluency (CF) worse than letter fluency (LF), naming worse than comprehension, and visual and verbal comprehension equally affected, suggesting disruption to an amodal semantic system. Individuals with AD demonstrated a similar pattern to a milder degree. Although PNFA, fvFTD, and PCA groups had abnormal scores (relative to controls) on most semantic measures, their differing patterns across measures indicate that the apparent semantic impairment in these conditions is largely secondary to other factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Recursion Engineering for Reduction Incorporated Parsers

Reduction Incorporated (RI) recognisers and parsers deliver high performance by suppressing the stack activity except for those rules that generate fully embedded recursion. Automaton constructions for RI parsing have been presented by Aycock and Horspool [John Aycock and Nigel Horspool. Faster generalised LR parsing. In Compiler Construction, 8th Intnl. Conf, CC'99, volume 1575 of Lecture Notes in Computer Science, pages 32 – 46. Springer-Verlag, 1999] and by Scott and Johnstone [Adrian Johnstone and Elizabeth Scott. Generalised regular parsers. In Gorel Hedin, editor, Compiler Construction, 12th Intnl. Conf, CC'03, volume 2622 of Lecture Notes in Computer Science, pages 232–246. Springer-Verlag, Berlin, 2003] but both can yield very large tables. An unusual aspect of the RI automaton is that the degree of stack activity suppression can be varied in a fine-grained way, and this provides a large family of potential RI automata for real programming languages, some of which have manageable table size but still show high performance. We give examples drawn from ANSI-C, Cobol and Pascal; discuss some heuristics for guiding manual specification of stack activity suppression; and describe work in progress on the automatic construction of RI automata using profiling information gathered from running parsers: in this way we propose to optimise our parsers' table size against performance on actual parsing tasks.     

Seismic Site Response for Near-Fault Forward Directivity Ground Motions

Forward directivity effects in the near-fault region produce pulse-type motions that differ significantly from ordinary ground motions that occur at greater distances from the causative fault. Current code site factors are based on empirical observations and analyses involving less intense nonpulse ordinary ground motions. Nonlinear site response analyses with bidirectional shaking are performed using representative site profiles to quantify seismic site response effects for intense near-fault motions resulting from forward directivity. Input rock motions are represented with simplified velocity pulses that characterize the amplitude and period of forward directivity motions. Results indicate that site response affects both the amplitude and period of forward directivity pulses, and hence, local site conditions should be considered when evaluating seismic designs in the near-fault region. Stiff soil sites tend to amplify the peak ground velocity and increase the period of pulse-type motions, particularly, when the period of the rock motion coincides with the degraded period of the site. Amplification is limited at soft soil sites by the dynamic strength of the weak soil, so attenuation occurs for intense input motions. This nonlinearity is not reflected in the site factors in current building codes. Guidance is provided for estimating the amplitude and pulse period for velocity pulses at soil sites.     

Touch-Space: Mixed Reality Game Space Based on Ubiquitous, Tangible, and Social Computing

This paper presents a novel computer entertainment system which recaptures human touch and physical interaction with the real-world environment as essential elements of the game play, whilst also maintaining the exciting fantasy features of traditional computer entertainment. Our system called ‘Touch-Space’ is an embodied (ubiquitous, tangible, and social) computing based Mixed Reality (MR) game space which regains the physical and social aspects of traditional game play. In this novel game space, the real-world environment is an essential and intrinsic game element, and the human’s physical context influences the game play. It also provides the full spectrum of game interaction experience ranging from the real physical environment (human to human and human to physical world interaction), to augmented reality, to the virtual environment. It allows tangible interactions between players and virtual objects, and collaborations between players in different levels of reality. Thus, the system re-invigorates computer entertainment systems with social human-to-human and human-to-physical touch interactions. Correspondence to: Professor A. Cheok, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260. Email: adriancheok@nus.edu.sg     

Mean-value analysis of multi-facility blocking models with state-dependent arrivals

A new mean-value type of algorithm is developed for analyzing multi-facility blocking models with state-dependent arrival rates. It can be applied to a broad class of blocking systems with simultaneous resource possession including, for example, circuit-switched networks. The underlying recursion is cast in terms of blocking probabilities and marginal state probabilities. The developments made here generalize previous results that were restricted to the case of constant arrival rates.     

Factorial validity of the CNSE..

A number of shortcomings have been noted in factorial studies of the Child Nowicki-Strickland Internal–External (CNS–IE) scale. Using different computational procedures, factor analysis of the CNS–IE responses of 2 independent samples of British schoolchildren (N?=?188; mean age 14.85 yrs) produced a factor that correlated significantly better with socialization than the total scale score. Results are discussed in terms of their implications for the factorial validity of the CNS–IE scale and the utility of locus of control subscales. (15 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)