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101.
Shinji Miwa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Kentaro Igarashi Hiroyuki Tsuchiya 《International journal of molecular sciences》2022,23(3)
Simple SummaryChondrosarcomas develop chemoresistance to standard anticancer drugs, making it difficult to control unresectable or metastatic chondrosarcomas. To improve the clinical outcomes of chondrosarcoma, new treatment approaches, such as molecule-targeting agents and immunotherapy, are needed. Recent research has revealed promising biomarkers and therapeutic targets for chondrosarcoma. In addition, several molecule-targeting agents have shown favorable antitumor activities in several clinical studies in patients with advanced sarcomas, including chondrosarcoma. This review summarizes recent basic studies on biomarkers and therapeutic targets and recent clinical studies on treating chondrosarcomas.AbstractDue to resistance to standard anticancer agents, it is difficult to control the disease progression in patients with metastatic or unresectable chondrosarcoma. Novel therapeutic approaches, such as molecule-targeting drugs and immunotherapy, are required to improve clinical outcomes in patients with advanced chondrosarcoma. Recent studies have suggested several promising biomarkers and therapeutic targets for chondrosarcoma, including IDH1/2 and COL2A1. Several molecule-targeting agents and immunotherapies have shown favorable antitumor activity in clinical studies in patients with advanced chondrosarcomas. This review summarizes recent basic studies on biomarkers and molecular targets and recent clinical studies on the treatment of chondrosarcomas. 相似文献
102.
Gel permeation chromatography of polyoxymethylene has been studied using N,N-dimethylformamide as the solvent. Polyoxymethylene samples used here are a copolymer of tetraoxane with 1,3-dioxolane and a commercial polyoxymethylene whose molecular weight distributions are moderately broad. Their intrinsic viscosities [η] range from 1.4 to 2.8 dl/g. Factors affecting chromatograms are discussed, and the operating conditions were determined by using the analytical scale GPC. On the basis of these operating conditions, the molecular weight fractionation of polyoxymethylene was carried out by using the preparative scale GPC. It was found that polyoxymethylene can be effectively fractionated to give seven to ten fractions each of them containing the fractionated polymer ranging in weight from 0.2 to 8 mg when 40 mg polymer sample was used for a run of the measurement. The fractionated polymers were also found to have a narrow molecular weight distribution within a single peak, and their Mw/Mn values decrease with increasing molecular weight. 相似文献
103.
Yoshihiko Okada Kaori Sasaki Baiqian Zhong Hideki Ishida Takeshi Mitsuda 《Journal of the American Ceramic Society》1994,77(5):1319-1323
A mixture of CaO and silicic acid prepared with a Ca/Si ratio of 2.0 was hydrothermally synthesized at 80° to 200°C, and the thermal decomposition behavior of the products (C-S-H with Ca(OH)2 ) was analyzed using XRD, 29 Si MAS NMR, and the trimethylsililation method (TMS). It was found that the main silicate anion structure of C-S-H was a mixture of a dimer and a single-chain polymer (larger than Si5 O16 ) and that polymerization advanced with an increase of the synthesizing temperature. On heating, the products decomposed to form β-C2 S. It was found that the decomposition was gradual and that the-higher the temperature of hydrothermal synthesis, the lower was the temperature of the decomposition into β-C2 S. Although the decomposition proceeded to form a monomer (β-C2 S) from the polymer and dimer, this dimer was resistant to heat and did not decompose unless heated to above 400°C. 相似文献
104.
Feng Ren Shingo Ishida Nobuyuki Takeuchi 《Journal of the American Ceramic Society》1993,76(7):1825-1831
The distribution and chemical states of vanadium in V-doped ZrO2 were studied to clarify the origin of the color of vanadium-zirconium yellow pigment in comparison with vanadium-tin yellow pigment. ESCA data and measurements of lattice constants of V-doped ZrO2 revealed that vanadium was dissolved mainly as V4+ substituting for Zr in ZrO2 lattice, and its solubility limit was 0.5 wt% as V2 O5 . It was found that the yellow color of vanadium-zirconium yellow was produced predominantly by the dissolved vanadium and that the contribution of vanadium oxide on ZrO2 grains to the yellow color was about 1/30 of that of the dissolved vanadium when compared on the basis of equimolar quantity of vanadium. Most of the undissolved vanadium oxide was in an amorphous or a poorly crystallized state. 相似文献
105.
Hyunjeong Kim Kouji Sakaki Itoko Saita Hirotoshi Enoki Kazuo Noguchi Akihiko Machida Tetsu Watanuki Yumiko Nakamura 《International Journal of Hydrogen Energy》2014
The effect of the vanadium content on the cyclic stability of V–Ti binary alloys was investigated. V1−xTix, x = 0.2 and 0.5 samples were hydrogenated and dehydrogenated at 410 K and 553 K respectively, for more than 100 times. During hydrogen cycling, reduction in the reversible hydrogen storage capacity was clearly observed from both samples. No prominent V-effect was found. In fact, the reduction rates of two samples were similar; both samples showed a ∼25% reduction in the reversible hydrogen storage capacity after 100 cycles. In addition, the shape of the pressure–composition-isotherm (PCT) curves was significantly altered over the testing cycle period; the absorption and desorption plateaus got markedly inclined and the hysteresis became evidently smaller. We found that even after the hydrogen storage capacity of V1−xTix was significantly reduced, at low enough temperature V1−xTix was able to absorb hydrogen as much as it did at the first cycle. Furthermore, the reversible hydrogen storage capacity of V0.8Ti0.2 at 410 K was recovered to a certain degree after hydrogenating the sample at low temperatures. 相似文献
106.
The effects of ageing at 473–573 K on the hardness, microstructure and thermoelastic martensitic transformation in Cu–Al–Mn-based shape memory alloys were investigated. It was found that hardness was dramatically increased by ageing due to the formation of fine bainitic plates and that the volume fraction of the bainite phase with ageing time can be described by the Austin–Rickett equation. The martensitic transformation temperatures decreased with the formation of bainite plates, mainly due to the composition change of the β-matrix. Moreover, the growth of thermally induced martensite plates was disturbed by the existence of bainite plates. Consequently, the transformation intervals (Ms–Mf and Af–As) and transformation hystereses (Af–Ms and As–Mf) increased with the progress of bainitic transformation. 相似文献
107.
108.
Effect of treatment of activated carbon fiber cloth electrodes with cold plasma upon performance of electric double-layer capacitors 总被引:4,自引:0,他引:4
Masashi Ishikawa Atsushi Sakamoto Masayuki Monta Yoshiharu Matsuda Koichi Ishida 《Journal of power sources》1996,60(2):233-238
Charge/discharge behavior of electric double-layer capacitors composed of activated carbon fiber cloth (ACFC) electrodes and an organic electrolyte was investigated. The modification of the ACFC electrodes was performed using cold plasma generated in argon-oxygen atmosphere. The effect of the cold plasma treatment of the ACPC electrodes on the capacitor performance was discussed on the basis of the physical and chemical properties of the ACFC surface such as pore radius distribution and surface atom concentration. 相似文献
109.
Model composites of spherical glass particles dispersed in a matrix of high density polyethylene were prepared with controlled variations in the interfacial structure. Dynamic-mechanical measurements of the composites in the melt state were recorded. The physical properties are found to relate to the morphology, bonding, reactivity, and other characteristics of the interfacial region which can be controlled by the applied chemistry. The interfacial reactions can be monitored in-sity by dynamic-mechanical analysis and differential scanning calorimetry. 相似文献
110.
R.Y. Umetsu K. ItoW. Ito K. Koyama T. KanomataK. Ishida R. Kainuma 《Journal of Alloys and Compounds》2011,509(5):1389-1393
High-field magnetic measurements were carried out in order to investigate behaviors of field-induced reverse martensitic transformation and kinetic arrest of NiCoMnSn metamagnetic shape memory alloy. In the thermomagnetization curves, it was confirmed that the reverse martensitic transformation temperature decreases 67 K by applying magnetic field of 5 T, while in the magnetic field cooling process under 5 T, martensitic transformation does not occur down to low temperatures. Equilibrium magnetic field, defined from the critical magnetic fields of the metamagnetic evidence in the magnetization curves, exhibits almost constant below about 100 K, suggesting that the entropy change becomes zero, which is considered to cause kinetic arrest behavior. 相似文献