Development of early expressive and communicative action: Reinterpreting the evidence from a dynamic systems perspective.

A systems approach is introduced and applied to the development of expressive and communicative action of infants in the first year of life. In this approach, expressive and communicative actions are organized, as part of cooperative systems with other elements of the infants' physiology, cognition, behavior, and social environment. A systems approach presumes that order arises dynamically as a result of the interaction between the cooperating elements that are changing asynchronously, rather than as the result of centrally coordinated developmental change that is synchronous across domains. The systems approach further assumes that the control parameter responsible for eliciting developmental change may be different depending on age, context, and task. It offers a means to understand previously unexplained developmental phenomena: the appearance of mature forms of expression before mature functon has been achieved, the asynchronous rates of development of communicative-action components, discontinuous developmental shifts arising from continuous processes, and the process by which adults influence communicative development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Some electron microscope observations of longitudinal splitting from surface flaws in Kevlar 29

Journal of Materials Science Letters -     

Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids

Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patients available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement.     

Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines

Certain bacterial immunostimulatory (i.s.) DNA sequences containing unmethylated CpG motifs stimulate antigen-presenting cells (APC) to express a full complement of costimulatory molecules and to produce cytokines including interleukin (IL)-12 and tumor necrosis factor (TNF)-alpha. While IL-12 is key to their T helper cell (Th)1-promoting adjuvant activity, secretion of toxic levels of TNF-alpha is harmful in that it promotes toxic shock. Given the beneficial as well as harmful consequences of i.s. DNA, we investigated the possibility of identifying DNA sequences, i.e. CpG oligodeoxynucleotides (ODN) which differentially activate IL-12 versus TNF-alpha cytokine production in APC. Here, we describe an i.s. DNA sequence with these characteristics. While its potential to induce IL-12 is preserved, its ability to trigger TNF-alpha release is strongly curtailed both in vitro and in vivo. I.s. DNA could be segregated into lethal and non-lethal in a mouse toxic shock model. The non-toxic i.s. DNA was useful as an adjuvant, thus allowing cytotoxic T cell responses to the soluble protein ovalbumin and conferring a resistant Th 1 phenotype to BALB/c mice lethally infected with Leishmania major. This i.s. CpG motif may thus be prototypic for a useful immunostimulating DNA sequence that lacks harmful side effects.     

A specific antidote for the treatment of digitalis poisoning in uremic patients

Two chronic haemodialyzed patients with digitalis intoxication are reported. One of them took digoxin 0.25 mg three times daily for an unknown period and the other took digitoxin 0.1 mg twice daily for two weeks. The symptoms of intoxication were mainly concealed by uremic syndrome. The diagnosis was established by noticed sinus bradycardia, first- and second-degree atrioventricular block in ECG and the determination of sera levels of glycosides (serum digoxin concentration was 7.36 ng/ml, serum digitoxin concentration was 46.5 ng/ml) in both cases. Considering the probable long elimination period of digitalis and the potentially life-threatening situation the patients were given digoxin-specific antibody (Fab) fragments with potassium replacement therapy. The symptoms disappeared within a few hours after therapy, side effects and rebound toxicity did not develop. In connection with these cases the aim of this report is to publish a method which can reverse the life-threatening digitalis intoxication in patients suffering from renal failure as well. As to the above method, the authors have not found any similar case reports in the Hungarian medical literature.     

Path integral Monte Carlo simulations of the melting of molecular hydrogen surfaces

We have used Path Integral Monte Carlo to study the surface melting of molecular hydrogen. Density profiles perpendicular and parallel to the bare H₂ surface are computed showing the formation of a liquid adlayer at 6 K, less than half the bulk melting temperature of para-hydrogen, 13.8 K. To estimate the onset temperature and depth of H₂ surface melting we determine the static structure factor within the individual H₂-layers for wave vectors in the plane and find no crystalline order down to 3 K in a partially filled H₂ adlayer at the free surface. We find quantum effects amplify the melting point depression at the free H₂ surface compared to bulk by a factor of five over classical Lennard-Jones solids and find that the zero-point fluctuations of molecules at the surface are much enhanced over their bulk values. We see vacancy formation in the solid before melting.     

Reduction of Radiation-Induced Hair Loss by Topical Application of Radioprotectors

ABSTRACT

Our transdermal permeation studies of radioprotectors in permeation-enhancing vehicles led us to hypothesize that radiation-induced hair loss could be reduced by topical application of radioprotectors. In the present study we used a hair regrowth assay in “plucked” mice to measure the radioprotective effectiveness of WR-1065, cysteine and TEMPOL when they were dissolved in a variety of vehicles, i.e., saline, dimethyl formamide (DMF), propylene glycol (PG), dimethyl sulfoxide (DMSO), ethanol. Protector effectiveness varied with radiation dose and vehicles. At 600 R, WR-1065 or cysteine, in any vehicle, reduced radiation-induced baldness scores; at 800 R, only WR-1065 in DMF and cysteine in saline, produced some protection. TEMPOL in ethanol produced protection at both the 600 and 800 R. Results suggest that suitably chosen topical application of protector/vehicle combinations can reduce radiation-induced hair loss.     

Blind MPEG-2 video watermarking robust against geometric attacks: a set of approaches in DCT domain.

A set of robust MPEG-2 video watermarking techniques is proposed, focusing on commonly used typical geometric processing for bit-rate reduction, cropping, removal of any rows, arbitrary-ratio downscaling, and frame dropping. Both the embedding and the extraction of watermarks are done in the compressed domain, so the computational cost is low. Moreover, the watermark extraction is blind, i.e., no original unwatermarked MPEG-2 video is needed for watermark extraction. The presented technique is applicable not only to MPEG-2 video, but also to other DCT-based coding videos. Selected experimental results validate our techniques.     

THE LOW CYCLE IMPACT FATIGUE PROPERTIES OF PEARLITIC PLAIN CARBON STEELS

The results of Stan ton and Bairstow (1908) have been reanalyzed to yield information on the composition dependence of the low cycle impact fatigue properties of pearlitic plain carbon steels. It has been found that the energy absorbed per impact, E_i, and the number of impacts are failure, N_f, are related by the equation: In this equation q is determined by the carbon, manganese and silicon contents of the steel; E_o is the impact endurance limit; and C and D are constants. The curve represented by this equation intersects that representing the Johnson-Keller high cycle impact fatigue equation at a value of log_eN_f equal to 1/C. Thus, the transition from low to high cycle impact fatigue occurs at this value of log_eN_f.