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101.
Gabriele Mocciaro Simona DAmore Benjamin Jenkins Richard Kay Antonio Murgia Luis Vicente Herrera-Marcos Stefanie Neun Alice P. Sowton Zoe Hall Susana Alejandra Palma-Duran Giuseppe Palasciano Frank Reimann Andrew Murray Patrizia Suppressa Carlo Sabb Antonio Moschetta Albert Koulman Julian L. Griffin Michele Vacca 《International journal of molecular sciences》2022,23(12)
The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors characterised by central obesity, atherogenic dyslipidaemia, and changes in the circulating lipidome; the underlying mechanisms that lead to this lipid remodelling have only been partially elucidated. This study used an integrated “omics” approach (untargeted whole serum lipidomics, targeted proteomics, and lipoprotein lipidomics) to study lipoprotein remodelling and HDL composition in subjects with central obesity diagnosed with MetS (vs. controls). Compared with healthy subjects, MetS patients showed higher free fatty acids, diglycerides, phosphatidylcholines, and triglycerides, particularly those enriched in products of de novo lipogenesis. On the other hand, the “lysophosphatidylcholines to phosphatidylcholines” and “cholesteryl ester to free cholesterol” ratios were reduced, pointing to a lower activity of lecithin cholesterol acyltransferase (LCAT) in MetS; LCAT activity (directly measured and predicted by lipidomic ratios) was positively correlated with high-density lipoprotein cholesterol (HDL-C) and negatively correlated with body mass index (BMI) and insulin resistance. Moreover, many phosphatidylcholines and sphingomyelins were significantly lower in the HDL of MetS patients and strongly correlated with BMI and clinical metabolic parameters. These results suggest that MetS is associated with an impairment of phospholipid metabolism in HDL, partially led by LCAT, and associated with obesity and underlying insulin resistance. This study proposes a candidate strategy to use integrated “omics” approaches to gain mechanistic insights into lipoprotein remodelling, thus deepening the knowledge regarding the molecular basis of the association between MetS and atherosclerosis. 相似文献
102.
Albert P. Doerschuk B. F. Daubert 《Journal of the American Oil Chemists' Society》1948,25(12):425-433
Summary Corn oil was subjected to a low-temperature solventfractionation process and separated into 19 glyceride fractions; the glyceride
structures of the fractions were calculated and added to obtain the glyceride structure of the oil. The experimentally obtained
glyceride structure was compared to the structures calculated according to the mono-acid triglyceride, random, even, and partial
random schemes and was found to agree most closely with the partial random system.
The generous financial assistance of the Corn Products Refining Company, Argo, Illinois, is gratefully acknowledged.
Contribution from the Department of Chemistry, University of Pittsburgh. 相似文献
103.
Summary A non-reducing disaccharide has been isolated from the kernels of tung (Aleurites fordi Hemsl.) and identified as sucrose. 相似文献
104.
P. Ganesh Kumar T. Aruldoss Albert VictoireP. Renukadevi D. Devaraj 《Expert systems with applications》2012,39(2):1811-1821
Knowledge gained through classification of microarray gene expression data is increasingly important as they are useful for phenotype classification of diseases. Different from black box methods, fuzzy expert system can produce interpretable classifier with knowledge expressed in terms of if-then rules and membership function. This paper proposes a novel Genetic Swarm Algorithm (GSA) for obtaining near optimal rule set and membership function tuning. Advanced and problem specific genetic operators are proposed to improve the convergence of GSA and classification accuracy. The performance of the proposed approach is evaluated using six gene expression data sets. From the simulation study it is found that the proposed approach generated a compact fuzzy system with high classification accuracy for all the data sets when compared with other approaches. 相似文献
105.
C. Hassel K. Blaum T. Day Goodacre H. Dorrer Ch. E. Düllmann K. Eberhardt S. Eliseev C. Enss P. Filianin A. Fäßler A. Fleischmann L. Gastaldo M. Goncharov D. Hengstler J. Jochum K. Johnston M. Keller S. Kempf T. Kieck U. Köster M. Krantz B. Marsh C. Mokry Yu. N. Novikov P. C. O. Ranitzsch S. Rothe A. Rischka J. Runke A. Saenz F. Schneider S. Scholl R. X. Schüssler F. Simkovic T. Stora P. Thörle-Pospiech A. Türler M. Veinhard M. Wegner K. Wendt K. Zuber 《Journal of Low Temperature Physics》2016,184(3-4):910-921
106.
Obead Yaseen Maher M. El‐Masri Wasim S. El Nekidy Derrick Soong Mohammed Ibrahim John W. Speirs Albert Kadri 《Hemodialysis international. International Symposium on Home Hemodialysis》2013,17(3):434-440
Hemodialysis catheter (HDC) dysfunction due to thrombosis is common, and dysfunction incidence can reach up to 50% within 1 year of use. Although administration of intraluminal alteplase (tissue plasminogen activator [tPA]) is the standard of practice to pharmacologically restore HDC function, there are no evidence‐based guidelines concerning the optimal tPA dose. The purpose of this study was to compare the efficacy of 1.0‐mg vs. 2.0‐mg tPA dwell protocols in restoring the HDC function in thrombotic dysfunctional catheters. A retrospective, single‐center study was conducted on two independent cohorts of patients; the first (n = 129) received 2.0 mg tPA/catheter lumen, while the second (n = 108) received 1.0 mg tPA/catheter lumen. Kaplan–Meier and Cox regression analyses were performed to compare the catheter survival time between patients who received 1.0 mg tPA and those who received 2.0 mg tPA. Catheter removal occurred in 25 (19.4%) of those catheters treated with 1.0 mg tPA compared with 11 (10.2%) of catheters treated with 2.0 mg tPA (P = 0.05). The hazard ratio (HR) for catheter removal was 2.75 (95% confidence interval [95%CI] = 1.25–6.04) for the 1.0‐mg tPA cohort compared with the 2.0‐mg tPA cohort. Correction added on 3 December 2012, after first online publication: The tPA cohort values were changed. Female gender (HR = 2.51; 95%CI = 1.20–5.27) and age (HR = 0.96; 95%CI = 0.94–0.98) were also associated with catheter survival. Our findings suggest that treatment of dysfunctional HDC with 2.0‐mg tPA dwells is superior to 1.0‐mg tPA dwells. 相似文献
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