Comparative Coreflood Studies for Precipitation and Adsorption Squeeze with PPCA as the Scales Inhibitor

Comparative adsorption and precipitation squeezes carried out on field core materials demonstrate that significant lifetime enhancement is achievable for precipitation squeeze with respect to more conventional adsorption squeeze. Coreflood tests have been carried out under reservoir conditions (135°C) employing a poly-phosphinocarboxylate (PPCA) as the scales inhibitor. Field treatment simulations, carried out starting from coreflood data and considering the characteristics of a North Sea formation taken as the reference, confirmed the higher performance, in term of squeeze lifetime, of the precipitation squeeze with respect to adsorption. The results pointed out the importance of choosing the appropriate formulation once the operative conditions are known, in order to promote the inhibitor precipitation into the formation. Some implications of these results for the optimization of the precipitation squeeze technology for field applications, with particular emphasis to formation damage, are also discussed.     

Mumps orchitis; review of 8 cases]

The occurrence of secondary hypogonadism is a common finding in males who seek help with erectile dysfunction, although the relationship to diminished testosterone is unclear. Two possibilities exist regarding both the genesis and maintenance of the hypogonadotropic hypogonadal state. First, a defect in hypothalamic function, resulting in downregulation as well as in alterations of anterior pituitary function; second, estradiol inhibition of gonadotropin release, both of which result in decreased testosterone production. As testosterone levels decrease and estradiol levels increase, the ratio of free testosterone to estradiol reaches a critical point and the estrogenic gonadotropin suppressive effects predominate. This ratio may signal the biological point of no return and could become one of the criteria for defining the separation of the transitional hypogonadal state from the final 'end stage' hypogonadotropic hypogonadal state. As the aging process continues, there is a relative accumulation of fatty tissue, and aromatization accelerates the conversion of testosterone to estradiol. This additional secondary estradiol inhibition results in the maintenance of the testosterone deficient state, and the aging process continues uncontested.     

Symbolic analysis of linear polyhedra

This paper concerns several analytical problems related to linear polyhedra in euclidean three-dimensional-space. Symbolic formulas for line, surface, and volume integration are given, and it is shown that domain integrals are computable in polynomial time. In particular, it is shown that mass, first and second moments, and products of inertia are computable inO(E) time, whereE is the number of edges of the boundary. Simple symbolic expressions for the normal derivatives of domain integrals are also derived. In particular, it is shown that they are closely linked to the topology of the integration domain, as well as that they are expressible as combinations of domain integrals over lower-order domains (faces, edges, and vertices). The symbolic results presented in this paper may lead to an easy incorporation of integral constraints, for example, concerning mass and inertia, in the engineering designing process of solid objects.     

First experiences of teaching quantum computing

The Journal of Supercomputing - Quantum computing is a reality that presents challenges to computer engineering students and practitioners. It has been claimed that it is possible to effectively...     

SIMCAN: A flexible, scalable and expandable simulation platform for modelling and simulating distributed architectures and applications

In this paper we propose a new simulation platform called SIMCAN, for analyzing parallel and distributed systems. This platform is aimed to test parallel and distributed architectures and applications. The main characteristics of SIMCAN are flexibility, accuracy, performance, and scalability. Thence, the proposed platform has a modular design that eases the integration of different basic systems on a single architecture. Its design follows a hierarchical schema that includes simple modules, basic systems (computing, memory managing, I/O, and networking), physical components (nodes, switches, …), and aggregations of components. New modules may also be incorporated as well to include new strategies and components. Also, a graphical configuration tool has been developed to help untrained users with the task of modelling new architectures. Finally, a validation process and some evaluation tests have been performed to evaluate the SIMCAN platform.     

Flavonoids of “La Alcarria” honey A study of their botanical origin

Summary The flavonoids present in ten selected samples of La Alcarria honey with different pollen compositions have been HPLC analysed in order to establish if correlations between botanical origin and flavonoid profiles are possible. A common flavonoid pattern is observed in the different samples showing that pollen is not the main source of honey flavonoids. A close correlation between the flavonoid patterns of honey flavonoids and propolis flavonoids has been found suggesting that flavonoid analysis could be more useful in geographical origin determinations than in botanical origin studies.

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Flavonoide des La-Alcarria-Honigs Eine Studie ihres botanischen Ursprungs

Zusammenfassung Die Flavonoide in Proben in Alcarria-Honig mit unterschiedlicher Pollenzusammensetzung wurden untersucht, um Kortrelationen zwischen dem botanischen Ursprung und den möglichen Flavonoiden zu finden. In den verschiedenen Proben wurde ein Flavonoid-Muster gefunden, wobei der Pollen nicht die Hauptquelle der Honigflavonoide ist. Es wurde jedoch eine enge Korrelation zwischen den Flavonoid-Mustern des Honigs und des Bienenkittharzes gefunden, was für die geographische Herkunft wichtiger ist als die botanische.

     

Transcriptomic Profiles of CD47 in Breast Tumors Predict Outcome and Are Associated with Immune Activation

Targeting the innate immune system has attracted attention with the development of anti- CD47 antibodies. Anti-CD47 antibodies block the inhibition of the phagocytic activity of macrophages caused by the up-regulation of CD47 on tumor cells. In this study, public genomic data was used to identify genes highly expressed in breast tumors with elevated CD47 expression and analyzed the association between the presence of tumor immune infiltrates and the expression of the selected genes. We found that 142 genes positively correlated with CD47, of which 83 predicted favorable and 32 detrimental relapse-free survival (RFS). From those associated with favorable RFS, we selected the genes with immunologic biological functions and defined a CD47-immune signature composed of PTPRC, HLA-E, TGFBR2, PTGER4, ETS1, and OPTN. In the basal-like and HER2+ breast cancer subtypes, the expression of the CD47-immune signature predicted favorable outcome, correlated with the presence of tumor immune infiltrates, and with gene expression signatures of T cell activation. Moreover, CD47 up-regulated genes associated with favorable survival correlated with pro-tumoral macrophages. In summary, we described a CD47-immune gene signature composed of 6 genes associated with favorable prognosis, T cell activation, and pro-tumoral macrophages in breast cancer tumors expressing high levels of CD47.     

Cyclic Nigerosyl-Nigerose as Oxygen Nanocarrier to Protect Cellular Models from Hypoxia/Reoxygenation Injury: Implications from an In Vitro Model

Heart failure (HF) prevalence is increasing among the aging population, and the mortality rate remains unacceptably high despite improvements in therapy. Myocardial ischemia (MI) and, consequently, ischemia/reperfusion injury (IRI), are frequently the basis of HF development. Therefore, cardioprotective strategies to limit IRI are mandatory. Nanocarriers have been proposed as alternative therapy for cardiovascular disease. Controlled reoxygenation may be a promising strategy. Novel nanocarriers, such as cyclic nigerosyl-nigerose (CNN), can be innovative tools for oxygen delivery in a controlled manner. In this study we analyzed new CNN-based formulations as oxygen nanocarriers (O₂-CNN), and compared them with nitrogen CNN (N₂-CNN). These different CNN-based formulations were tested using two cellular models, namely, cardiomyoblasts (H9c2), and endothelial (HMEC) cell lines, at different concentrations. The effects on the growth curve during normoxia (21% O₂, 5% CO₂ and 74% N₂) and their protective effects during hypoxia (1% O₂, 5% CO₂ and 94% N₂) and reoxygenation (21% O₂, 5% CO₂ and 74% N₂) were studied. Neither O₂-CNN nor N₂-CNN has any effect on the growth curve during normoxia. However, O₂-CNN applied before hypoxia induces a 15–30% reduction in cell mortality after hypoxia/re-oxygenation when compared to N₂-CNN. O₂-CNN showed a marked efficacy in controlled oxygenation, which suggests an interesting potential for the future medical application of soluble nanocarrier systems for MI treatment.     

Biomarkers in Glycogen Storage Diseases: An Update

Glycogen storage diseases (GSDs) are a group of 19 hereditary diseases caused by a lack of one or more enzymes involved in the synthesis or degradation of glycogen and are characterized by deposits or abnormal types of glycogen in tissues. Their frequency is very low and they are considered rare diseases. Except for X-linked type IX, the different types are inherited in an autosomal recessive pattern. In this study we reviewed the literature from 1977 to 2020 concerning GSDs, biomarkers, and metabolic imbalances in the symptoms of some GSDs. Most of the reported studies were performed with very few patients. Classification of emerging biomarkers between different types of diseases (hepatics GSDs, McArdle and PDs and other possible biomarkers) was done for better understanding. Calprotectin for hepatics GSDs and urinary glucose tetrasaccharide for Pompe disease have been approved for clinical use, and most of the markers mentioned in this review only need clinical validation, as a final step for their routine use. Most of the possible biomarkers are implied in hepatocellular adenomas, cardiomyopathies, in malfunction of skeletal muscle, in growth retardation, neutropenia, osteopenia and bowel inflammation. However, a few markers have lost interest due to a great variability of results, which is the case of biotinidase, actin alpha 2, smooth muscle, aorta and fibroblast growth factor receptor 4. This is the first review published on emerging biomarkers with a potential application to GSDs.