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81.
The aim of this study was to assess the influence of the amounts of the αS1-, αS2-, β-, and κ-casein (CN) and the α-lactalbumin and β-lactoglobulin protein fractions on the efficiency of the cheese-making process independently of their genetic polymorphisms. The study was carried out on milk samples from 1,271 Brown Swiss cows from 85 herds classified into 4 categories according to management, feeding, and housing characteristics (traditional and modern systems). To assess the efficiency of the cheese-making process, we processed the milk samples according to a laboratory cheese-making procedure (1,500 mL/sample) and obtained the following measures: (1) 3 percentage cheese yields (%CYcurd, %CYsolids, %CYwater), (2) 2 daily cheese yields obtained by multiplying %CY (curd and total solids) by daily milk yields (dCYcurd, dCYsolids), (3) 4 measures of nutrient recovery in the curd (RECfat, RECprotein, RECsolids, RECenergy), and (4) 2 measures of cheese-making efficiency in terms of the ratio between the observed and theoretical %CY (Ef-%CYcurd, Ef-%CYsolids). All the aforementioned traits were analyzed by fitting 2 linear mixed models with protein fractions as fixed effects expressed as percentage in the milk (model M-%milk) and as percentage of the total casein content (model M-%cas) together with the effects of total casein content (only in model M-%cas), daily milk yield (only in model M-%milk; not for dCY traits), dairy system, herd (random effect), days in milk, parity, and vat. The efficiency of overall cheese yield (Ef-%CYcurd) was mostly positively associated with β-CN content in the milk, whereas Ef-%CYsolids was greater with higher amounts of κ-CN and αS1-CN (M-%milk) due to the strong influence of both fractions on the recovery rate of milk components in the curd (fat and total solids, protein with αS1-CN only) when expressed as percentage of milk and of total casein; only β-CN was more important for RECprotein. In contrast, we found β-lactoglobulin to be highly negatively related to all the traits related to the cheese-making process and to the daily cheese yield per cow, whereas α-lactalbumin was positively associated with the latter traits. Additional research on this topic is needed, with particular focus on the genetic and genomic aspects of the role of protein fractions in the cheese-making process and on the associations between genetic polymorphisms in milk protein and milk nutrient recovery in the curd.  相似文献   
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83.
The synthesis and carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of two series of aromatic sulfonamides and their Cu(II) derivatives, incorporating metal-complexing moieties of the DTPA, DOTA, and TETA type are reported. The new compounds were designed in such a way as to possess high affinity for Cu(II) ions, exploiting four pendant carboxylate moieties in the DTPA derivatives, as well as the cyclen/cyclam macrocyles, and three pendant acetate moieties in the DOTA and TETA derivatives. The new derivatives showed modest inhibition of the cytosolic isoform CA I (K(I) values in the range of 66-2130 nM), were better CA II inhibitors (K(I) values in the range of 21-360 nM), and excellent inhibitors of the tumor-associated isoform CA IX (K(I) values in the range of 4.1-110 nM), with selectivity ratios for the inhibition of the tumor (CA IX) over the cytosolic (CA II) isozyme in the range of 10.74-20.88 for the best derivatives. Copper complexes were more inhibitory than the corresponding ligand sulfonamides, and showed membrane impermeability, thus, having the possibility to specifically target the transmembrane CA IX that has an extracellular active site. Incorporation of radioactive copper isotopes in this type of CA inhibitor may lead to interesting diagnostic/therapeutic applications for such compounds.  相似文献   
84.
A novel approach to the parallel coupling of normal-bore high-performance liquid chromatography (LC) with electrochemical-array detection (EC-array) and nanoelectrospray mass spectrometry (MS), based on the use of a nanosplitting interface, is described where both detectors are utilized at their optimal detection mode for parallel configuration. The dual detection platform was shown to maintain full chromatographic integrity with retention times and peak widths at half-height between the EC-array and MS displaying high reproducibility with relative standard deviations of <2%. Detection compatibility between the two detectors at the part per billion level injected on-column was demonstrated using selected metabolites representative of the diversity typically encountered in physiological systems. Metabolites were detected with equal efficiency whether neat or in serum, demonstrating the system's ability to handle biological samples with limited sample cleanup and reduced concern for biological matrix effects. Direct quantification of known analytes from the EC-array signal using Faraday's law can eliminate the need for isotopically labeled internal standards. The system was successfully applied to the detection and characterization of metabolites of phenylbutyrate from serum samples of Huntington's disease patients in an example that illustrates the complementarity of the dual detection nanoelectrospray LC-EC-array-MS system.  相似文献   
85.
The design of compounds selective for the MT1 melatonin receptor is still a challenging task owing to the limited knowledge of the structural features conferring selectivity for the MT1 subtype, and only few selective compounds have been reported so far. N‐(Anilinoalkyl)amides are a versatile class of melatonin receptor ligands that include nonselective MT1/MT2 agonists and MT2‐selective antagonists. We synthesized a new series of N‐(anilinoalkyl)amides bearing 3‐arylalkyloxy or 3‐alkyloxy substituents at the aniline ring, looking for new potent and MT1‐selective ligands. To evaluate the effect of substituent size and shape on binding affinity and intrinsic activity, both flexible and conformationally constrained derivatives were prepared. The phenylbutyloxy substituent gave the best result, providing the partial agonist 4 a , which was endowed with high MT1 binding affinity (pKi=8.93) and 78‐fold selectivity for the MT1 receptor. To investigate the molecular basis for agonist recognition, and to explain the role of the 3‐arylalkyloxy substituent, we built a homology model of the MT1 receptor based on the β2 adrenergic receptor crystal structure in its activated state. A binding mode for MT1 agonists is proposed, as well as a hypothesis regarding the receptor structural features responsible for MT1 selectivity of compounds with lipophilic arylalkyloxy substituents.  相似文献   
86.
The first evidence of out‐of‐plane resonances in hybrid metallo‐dielectric quasi‐crystal (QC) nanostructures composed of metal‐backed aperiodically patterned low‐contrast dielectric layers is reported. Via experimental measurements and full‐wave numerical simulations, these resonant phenomena are characterized with specific reference to the Ammann‐Beenker (quasi‐ periodic, octagonal) tiling lattice geometry and the underlying physics is investigated. In particular, it is shown that, by comparison with standard periodic structures, a moderately richer spectrum of resonant modes may be excited, due to the easier achievement of phase‐matching conditions endowed by its denser Bragg spectrum. Such modes are characterized by a distinctive plasmonic or photonic behavior, discriminated by their field distribution and dependence on the metal film thickness. Moreover, the response is accurately predicted via computationally affordable periodic‐approximant‐based numerical modeling. The enhanced capability of QCs to control number, spectral position, and mode distribution of hybrid resonances may be exploited in a variety of possible applications. To assess this aspect, label‐free biosensing is studied via characterization of the surface sensitivity of the proposed structures with respect to local refractive index changes. Moreover, it is also shown that the resonance‐engineering capabilities of QC nanostructures may be effectively exploited in order to enhance the absorption efficiency of thin‐film solar cells.  相似文献   
87.
In this work, the crossflow microfiltration (CFMF) performance of different lots of lager beer, produced in a pilot scale at the Italian Brewing Research Centre (CERB, Perugia, Italy), was assessed in a bench-top plant, equipped with a 0.8-μm ceramic tubular membrane module, under constant crossflow velocity of 6 m s?1, transmembrane pressure difference of 3.74 bar, temperature of ~10 °C, and periodic CO2 backflushing. By feeding different beer samples (i.e., as such, precentrifuged (C), or pretreated with a commercial enzyme preparation to degrade the original arabinoxylans and β-glucans and then centrifuged (EC) to minimize the fouling contribution of yeast cells, aggregates, and polysaccharides), it was possible to increase the average permeation flux (expressed as mean value?±?standard deviation) from 112?±?13 to 199?±?17 or 330?±?22 L m?2 h?1, respectively. Only when using the EC-pretreated beer specimens, the permeate turbidity at 20 °C approached the limiting one (<0.6 EBC unit) recommended by the European Brewery Convention standards. As expected, the permeate chill haze at 0 °C was generally higher than the above haze target. By submitting EC-pretreated beer seeded with 0.5 g L?1 of regenerable polyvinylpolypyrrolidone (PVPP) to CFMF, it was possible to reduce the initial total polyphenol content by 30 % and permeate chill haze to 0.60?±?0.01 EBC unit, but the average permeation flux fell to 84?±?4 L m?2 h?1. By performing sequentially EC pretreatments, PVPP stabilization, cartridge filtration, and CFMF, it was possible not only to re-enhance the average permeation flux at about 230 L m?2 h?1 near to those achievable with DE filters, but also to obtain a chill haze-free permeate ready for aseptic packaging.  相似文献   
88.
89.
Electrically conductive fabrics were produced by deposition of a thin film of doped polypyrrole on the surface of cotton fibres. In situ oxidative chemical polymerisation were carried out in aqueous solutions of pyrrole, oxidant and doping agents, at room temperature. Polypyrrole-coated fibres were characterized by Light Microscopy, SEM, EDX, FTIR and TGA. Moreover, fabric samples were also evaluated for moisture regain, electrical resistivity, heat generation and antibacterial activity. PPy alters the combustion process of cellulose fibres that maintain the fibrous shape after heating in air. Moreover, it seems that PPy is really an antibacterial agent, apart from the oxidant or dopant used. The results highlight potential applications as technical textiles with antistatic (low electrical resistance), heat generation, hygroscopy, antibacterial and high temperature resistance properties.  相似文献   
90.
MILD combustion is a recent development in the combustion of hydrocarbon fuels which promises high efficiencies and low NOx emissions. In this paper we analyze the mathematical and numerical modeling of a Jet in Hot Coflow (JHC) burner, which is designed to emulate a moderate and intense low oxygen dilution (MILD) combustion regime [1]. This paper initially discusses the effects of several modeling strategies on the prediction of the JHC flame structure using the CFD code FLUENT 6.3.26. Effects of various turbulence models and their boundary conditions have been studied. Moreover, the detailed kinetic mechanism adopted in the CFD simulations is successfully validated in the conditions of interest using recent literature data [2] on the effect of nitrogen dilution on the flame speeds of several CH4/H2/air lean mixtures. One of the aims of this paper is also to describe a methodology for computing pollutant formation in steady turbulent flows to verify its applicability to the MILD combustion regime. CFD results are post-processed for calculating the NOx using a numerical tool called Kinetic Post Processor (KPP). The modeling results agree with the experimental results [1] and support the proposed approach as a useful tool for optimizing the design of new burners also in the MILD combustion regime.  相似文献   
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