Resistant starch—An accessible fiber ingredient acceptable to the Western palate

Dietary fiber intakes in Western societies are concerningly low and do not reflect global recommended dietary fiber intakes for chronic disease prevention. Resistant starch (RS) is a fermentable dietary fiber that has attracted research interest. As an isolated ingredient, its fine particle size, relatively bland flavor, and white appearance may offer an appealing fiber source to the Western palate, accustomed to highly refined, processed grains. This review aims to provide a comprehensive insight into the current knowledge (classification, production methods, and characterization methods), health benefits, applications, and acceptability of RS. It further discusses the present market for commercially available RS ingredients and products containing ingredients high in RS. The literature currently highlights beneficial effects for dietary RS supplementation with respect to glucose metabolism, satiety, blood lipid profiles, and colonic health. An exploration of the market for commercial RS ingredients indicates a diverse range of products (from isolated RS2, RS3, and RS4) with numerous potential applications as partial or whole substitutes for traditional flour sources. They may increase the nutritional profile of a food product (e.g., by increasing the fiber content and lowering energy values) without significantly compromising its sensory and functional properties. Incorporating RS ingredients into staple food products (such as bread, pasta, and sweet baked goods) may thus offer an array of nutritional benefits to the consumer and a highly accessible functional ingredient to be greater exploited by the food industry.     

Educational recommender systems and their application in lifelong learning

The almost unlimited access to educational information plethora came with a drawback: finding meaningful material is not a straightforward task anymore. Recommender algorithms can be used to make smart decisions in complex information systems and help the users decide upon useful materials; therefore, they become a promising area in academia and industry. The current paper presents a survey on educational recommender systems (RS): a set of analysis criteria are exposed and the technological specifications and challenges of each analysed system are provided, in the context of the main trends in the development of RS. Also, an ontology-based educational recommendation mechanism is proposed and its application to lifelong learning is highlighted, proving that RS can successfully support new learning paradigms.     

Natural versus wastewater derived dissolved organic carbon: implications for the environmental fate of organic micropollutants

The interaction of organic micropollutants with dissolved organic carbon (DOC) can influence their transport, degradation and bioavailability. While this has been well established for natural organic carbon, very little is known regarding the influence of DOC on the fate of micropollutants during wastewater treatment and water recycling. Dissolved organic carbon-water partition coefficients (K_DOC) for wastewater derived and reference DOC were measured for a range of micropollutants using a depletion method with polydimethylsiloxane disks. For micropollutants with an octanol-water partition coefficient (log K_OW) greater than 4 there was a significant difference in K_DOC between reference and wastewater derived DOC, with partitioning to wastewater derived DOC over 1000 times lower for the most hydrophobic micropollutants. The interaction of nonylphenol with wastewater derived DOC from different stages of a wastewater and advanced water treatment train was studied, but little difference in K_DOC was observed. Organic carbon characterisation revealed that reference and wastewater derived DOC had very different properties due to their different origins. Consequently, the reduced sorption capacity of wastewater derived DOC may be related to their microbial origin which led to reduced aromaticity and lower molecular weight. This study suggests that for hydrophobic micropollutants (log K_OW > 4) a higher concentration of freely dissolved and thus bioavailable micropollutants is expected in the presence of wastewater derived DOC than predicted using K_DOC values quantified using reference DOC. The implication is that naturally derived DOC may not be an appropriate surrogate for wastewater derived DOC as a matrix for assessing the fate of micropollutants in engineered systems.     

Using retina modelling to characterize blinking: comparison between EOG and video analysis

A large number of car crashes are caused by drowsiness every year. The analysis of eye blinks provides reliable information about drowsiness. This paper proposes to study the relation between electrooculogram (EOG) and video analysis for blink detection and characterization. An original method to detect and characterize blinks from a video analysis is presented here. The method uses different filters based on the human retina modelling. A illumination robust filter is first used to normalize illumination variations of the video input. Then, Outer and an Inner Plexiform Layer filters are used to extract energy signals from eye area. The eye detection is processed mixing gradient and projection methods which makes it able to detect even closed eyes. The illumination robust filter makes it possible to detect the eyes even in night conditions, without using external lighting. The video analysis extracts two signals from the eye area measuring the quantity of static edges and moving edges. Blinks are then detected and characterized from these two signals. A comparison between the features extracted from the EOG and the same features extracted from the video analysis is then performed on a database of 14 different people. This study shows that some blink features extracted from the video are highly correlated with their EOG equivalent: the duration, the duration at 50%, the frequency, the percentage of eye closure at 80% and the amplitude velocity ratio. The frame rate influence on the accuracy of the different features extracted is also studied and enlightens on the need of a high frame rate camera to detect and characterize accurately blinks from a video analysis.     

Standardized tests fail to assess the effects of antibiotics on environmental bacteria

Pharmaceuticals are designed and used because of their specific biological effects. Over the past decade, compounds from various classes of pharmaceuticals have been detected in the environment. Concern has grown about the adverse effects pharmaceuticals in the environment might potentially have on human and ecological health. A sound risk assessment is therefore urgently needed for pharmaceuticals. Standardized tests for assessing the effects of chemicals on environmental organisms are widely used for this purpose. However it is questionable whether classical standardized tests give reliable data needed for environmental risk assessment. In this study we investigated the suitability of the respiration inhibition test OECD 209 for the assessment of the effects of antibiotics, disinfectants and cytotoxics on sewage sludge bacteria. We found that inhibition concentrations can strongly depend on the test period and the type of compound. We conclude that tests to assess the effects of pharmaceuticals on environmental organisms such as bacteria have to be evaluated before their results can be used in environmental risk assessment.     

Polymerization of lactams, 95 Preparation of polyesteramides by the anionic polymerization of ε-caprolactam in the presence of poly(ε-caprolactone)

Preparation of polyesteramides-poly[(ε-caprolactam)-co-(ε-caprolactone)]s by anionic polymerization of ε-caprolactam in the presence of poly(ε-caprolactone) at 150 °C was studied in this paper. ε-Caprolactam magnesium bromide was used as an initiator of polymerization and polymeric materials containing 5-25 wt% ε-caprolactone units were obtained. Thermal methods (DSC and DMA) were employed for characterization of poly[(ε-caprolactam)-co-(ε-caprolactone)]s and their mechanical properties were also evaluated. By introducing the activator with N-acyllactam structure, the polymerization rate increased and it was possible to carry out the polymerization at 110 °C. Mechanical properties of polyesteramides were influenced by both the content of ε-caprolactone units incorporated into copolymer and polymerization temperature. The mechanism of incorporation of poly(ε-caprolactone) is discussed. The results show that it is not possible to restrict exchange transacylation reactions, progressing in the course of polymerization, by kinetic tools.     

Jaboticaba berry peel intake prevents insulin‐resistance‐induced tau phosphorylation in mice

The hyperphosphorylation of microtubule‐associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as Alzheimer's disease. In this study, we used a high‐fat diet to induce obesity and insulin resistance in adult Swiss mice and checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. Furthermore, adipocytokines, inflammatory markers, and oxidative stress were assessed. Myrciaria jaboticaba peel has phenolic compounds (e.g., cyanidin, ellagic acid), dietary fiber and carotenoids, which contribute to great antioxidant capacity. Supplementation of the high‐fat diet with 4% M. jaboticaba peel prevented fat weight gain and reduced peripheral insulin resistance. The treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the Morris water maze test. Maintenance of neuronal viability, lower levels of hippocampal inflammatory markers, and improved brain antioxidant defenses were also related to the consumption of M. jaboticaba peel. These findings contribute to a better understanding of how a high‐fat diet supplemented with jaboticaba berry peel counteracts the impairment of cognitive functions caused by high‐fat diet intake and diet‐induced insulin resistance.     

Impact assessment of push-pull pest management on incomes,productivity and poverty among smallholder households in Eastern Uganda

The paper evaluates the impact of adoption of push-pull technology (PPT) on household welfare in terms of productivity, incomes and poverty status measured through per-capita food consumption in eastern Uganda. Push-pull is a habitat management strategy for the integrated management of stemborers, striga weeds and poor soil fertility involving the use of a natural repellent (push) and an attractant (pull). This biological technology simultaneously reduces the impact of three major production constraints to cereal-livestock farming in Africa ? pests, weeds and poor soil. Cross sectional survey data were collected from 560 households in four districts in the region (Busia, Tororo, Bugiri and Pallisa), in November and December 2014. Generalized propensity scoring (GPS) was used to determine the intensity of adoption of the technology (i.e., land area allocated to PPT) and also to estimate the dose-response function (DRF) relating intensity of adoption and household welfare. Results revealed that with increased intensity of reported adoption of PPT, the probability of being poor declined through increased maize yield per unit area, incomes, and per capita food consumption. However, its impact varied with the intensity of adoption. With an increase in the area allocated to PPT from 0.025 to 1 acre, average maize yield per unit area increased from 27 kg to 1400 kg, average household income increased from 135 US$ (Uganda Shilling (USh) 370,000) to 273 US$ (USh 750,000) and per capita food consumption increased from 15 US$ (USh 40,000) to 27 US$ (USh 75,000). The average probability of a household being poor (below a rural poverty line of US$ 12.71) declined from 48% to 28%. These findings imply that increased investment in the dissemination and expansion of PPT is essential for poverty reduction among smallholder farmers in Uganda.     

Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the oxidative cleavage of l -Tryptophan (l -Trp) to yield N-formyl-kynurenine in the first and rate limiting step of the kynurenine pathway. Bioactive metabolites, involved in the regulation of important immunological responses and neurological processes, are then produced by downstream enzymes along the pathway. Inhibitors of IDO1 are being designed and developed as therapeutic agents for immuno-oncology. In this work, we investigated the molecular recognition path of l -Trp to IDO1, integrating biophysical methods with supervised molecular dynamics (suMD) and mutagenesis experiments. Results allowed disclosing for the first time high and low dissociation constants of l -Trp to IDO1, and the presence of a metastable interaction site located at the upper part of a channel whose borders are defined by the EF-loop and the C-terminal part of the JK-loop. Collectively, our results provide new clues for the design of next-generation IDO1 ligands.     

Natural Lignocellulosic Fibers as Engineering Materials—An Overview

Recent investigations on the tensile properties of natural cellulose-based fibers revealed an increasing potential as engineering materials. This is particularly the case of very thin fibers of some species such as sisal, ramie, and curaua. However, several other commonly used fibers such as flax, jute, hemp, coir, cotton, and bamboo as well as less known bagasse, piassava, sponge gourde, and buriti display tensile properties that could qualify them as engineering materials. An overview of the strength limits attained by these fibers is presented. Based on a tensile strength vs density chart, it is shown that natural fibers stand out as a relevant class of engineering materials.