High throughput blood plasma separation using a passive PMMA microfluidic device

Since plasma is rich in many biomarkers used in clinical diagnostic experiments, microscale blood plasma separation is a primitive step in most of microfluidic analytical chips. In this paper, a passive microfluidic device for on-chip blood plasma separation based on Zweifach–Fung effect and plasma skimming was designed and fabricated by hot embossing of microchannels on a PMMA substrate and thermal bonding process. Human blood was diluted in various times and injected into the device. The main novelty of the proposed microfluidic device is the design of diffuser-shaped daughter channels. Our results demonstrated that this design exerted a considerable positive influence on the separation efficiency of the passive separator device, and the separation efficiency of 66.6 % was achieved. The optimum purity efficiency of 70 % was achieved for 1:100 dilution times.     

Solving a bi-criteria permutation flow-shop problem using shuffled frog-leaping algorithm

Flow shop problems as a typical manufacturing challenge have gained wide attention in academic fields. In this paper, we consider a bi-criteria permutation flow shop scheduling problem, where the weighted mean completion time and the weighted mean tardiness are to be minimized simultaneously. Due to the complexity of the problem, it is very difficult to obtain optimum solution for this kind of problems by means of traditional approaches. Therefore, a new multi-objective shuffled frog-leaping algorithm (MOSFLA) is introduced for the first time to search locally Pareto-optimal frontier for the given problem. To prove the efficiency of the proposed algorithm, various test problems are solved and the reliability of the proposed algorithm, based on some comparison metrics, is compared with three distinguished multi-objective genetic algorithms, i.e. PS-NC GA, NSGA-II, and SPEA-II. The computational results show that the proposed MOSFLA performs better than the above genetic algorithms, especially for the large-sized problems.     

Modeling industrial thickener using computational fluid dynamics (CFD), a case study: Tailing thickener in the Sarcheshmeh copper mine

Separation of particles from liquid in the large gravitational tanks is widely used in mining and industrial wastewater treatment process. Thickener is key unit in the operational processes of hydrometallurgy and is used to separate solid from liquid. In this study, population balance models were combined with computational fluid dynamics (CFD) for modeling the tailing thickener. Parameters such as feed flow rate, flocculant dosage, inlet solid percent and feedwell were investigated. CFD was used to simulate the industrial tailing thickener with settled bed of 120 m diameter which is located in the Sarcheshmeh copper mine. Important factor of drag force that defines the rake torque of rotating paddles on the bed was also determined. Two phases turbulence model of Eulerian/Eulerian in accordance with turbulence model of k-ε was used in the steady-state. Also population balance model consists of 15 groups of particle sizes with Luo and Lehr kernel was used for aggregation/breakage kernel. The simulation results showed good agreement with the operational data.     

A Simulation-Based Optimization Model for Flood Management on a Watershed Scale

Using structural and nonstructural measures for flood damage reduction is a long-standing problem in water resources planning and management. In the present study, an algorithm is presented for the optimal design of structural and nonstructural flood mitigation measures based on simulation-based optimization approach. For this purpose, the MIKE-11 simulation model, a one-dimensional hydrodynamic model, was used to calculate the potential damages of different flood scenarios under the various combinations of structural and nonstructural measures and this model was coupled with the NSGA-II multi-objective optimization model to provide the optimal Pareto solutions between two conflict objectives of minimizing the investment costs of flood mitigation measures and the potential damages of the floodplain. The proposed model was then applied to a small watershed in central part of Iran as a case study and the optimal trade-off solutions were calculated for different flood scenarios. Using these trade-offs, for each level of funding, decision makers can assign the optimal design of flood mitigation measures considering decision criteria.     

A general insight into the effect of neuron structure on classification

This paper gives a general insight into how the neuron structure in a multilayer perceptron (MLP) can affect the ability of neurons to deal with classification. Most of the common neuron structures are based on monotonic activation functions and linear input mappings. In comparison, the proposed neuron structure utilizes a nonmonotonic activation function and/or a nonlinear input mapping to increase the power of a neuron. An MLP of these high power neurons usually requires a less number of hidden nodes than conventional MLP for solving classification problems. The fewer number of neurons is equivalent to the smaller number of network weights that must be optimally determined by a learning algorithm. The performance of learning algorithm is usually improved by reducing the number of weights, i.e., the dimension of the search space. This usually helps the learning algorithm to escape local optimums, and also, the convergence speed of the algorithm is increased regardless of which algorithm is used for learning. Several 2-dimensional examples are provided manually to visualize how the number of neurons can be reduced by choosing an appropriate neuron structure. Moreover, to show the efficiency of the proposed scheme in solving real-world classification problems, the Iris data classification problem is solved using an MLP whose neurons are equipped by nonmonotonic activation functions, and the result is compared with two well-known monotonic activation functions.     

A general computational recognition primed decision model with multi-agent rescue simulation benchmark

Analytical decision making strategies rely on weighing pros and cons of multiple options in an unbounded rationality manner. Contrary to these strategies, recognition primed decision (RPD) model which is a primary naturalistic decision making (NDM) approach assumes that experienced and professional decision makers when encounter problems in real operating conditions are able to use their previous experiences and trainings in order to diagnose the problem, recall the appropriate solution, evaluate it mentally, and implement it to handle the problem in a satisficing manner. In this paper, a computational form of RPD, now called C-RPD, is presented. Unified Modeling Language was used as a modeling language to represent the proposed C-RPD model in order to make the implementation easy and obvious. To execute the model, RoboCup Rescue agent simulation environment, which is one of the best and the most famous complex and multi-agent large-scale environments, was selected. The environment simulates the incidence of fire and earthquakes in urban areas where it is the duty of the police forces, firefighters and ambulance teams to control the crisis. Firefighters of SOS team are first modeled and implemented by utilizing C-RPD and then the system is trained using an expert’s experience. There are two evaluations. To find out the convergence of different versions developed during experience adding, some of the developed versions are chosen and evaluated on seven maps. Results show performance improvements. The SOS team ranked first in an official world championship and three official open tournaments.     

Cluster Size Optimization in Sensor Networks with Decentralized Cluster-Based Protocols

Network lifetime and energy-efficiency are viewed as the dominating considerations in designing cluster-based communication protocols for wireless sensor networks. This paper analytically provides the optimal cluster size that minimizes the total energy expenditure in such networks, where all sensors communicate data through their elected cluster heads to the base station in a decentralized fashion. LEACH, LEACH-Coverage, and DBS comprise three cluster-based protocols investigated in this paper that do not require any centralized support from a certain node. The analytical outcomes are given in the form of closed-form expressions for various widely-used network configurations. Extensive simulations on different networks are used to confirm the expectations based on the analytical results. To obtain a thorough understanding of the results, cluster number variability problem is identified and inspected from the energy consumption point of view.     

Multiple model bank selection based on nonlinearity measure and H-gap metric

This paper provides a systematic method for model bank selection in multi-linear model analysis for nonlinear systems by presenting a new algorithm which incorporates a nonlinearity measure and a modified gap based metric. This algorithm is developed for off-line use, but can be implemented for on-line usage. Initially, the nonlinearity measure analysis based on the higher order statistic (HOS) and the linear cross correlation methods are used for decomposing the total operating space into several regions with linear models. The resulting linear models are then used to construct the primary model bank. In order to avoid unnecessary linear local models in the primary model bank, a gap based metric is introduced and applied in order to merge similar linear local models. In order to illustrate the usefulness of the proposed algorithm, two simulation examples are presented: a pH neutralization plant and a continuous stirred tank reactor (CSTR).     

Flow resistance in a compound gravel-bed bend

In this paper, the effect of a gravel-bed in a compound bend (similar to sinusoidal top view) of a natural river (Zayandehrud River flowing through Isfahan, Iran) has been investigated for flow resistance analysis, measuring the velocity with a micro current meter. The data were analysed and the following observations were made. In a compound bend, the law of the wall can be valid for up to 66% of the flow depth from the bed. The parabolic law is the most effective method for the determination of shear velocity. Based on the existing criteria for verifying the equilibrium boundary layer, the flow cannot be in equilibrium. The shear stress distribution and the sediment transport parameters have considerable influence on resistance to flow. Froude number and the flow depth relative to the representative gravel size have little effect on the flow resistance estimation.     

Noise analysis and characterization of a sigma-delta capacitive microaccelerometer

This paper reports a high-sensitivity low-noise capacitive accelerometer system with one micro-g//spl radic/Hz resolution. The accelerometer and interface electronics together operate as a second-order electromechanical sigma-delta modulator. A detailed noise analysis of electromechanical sigma-delta capacitive accelerometers with a final goal of achieving sub-/spl mu/g resolution is also presented. The analysis and test results have shown that amplifier thermal and sensor charging reference voltage noises are dominant in open-loop mode of operation. For closed-loop mode of operation, mass-residual motion is the dominant noise source at low sampling frequencies. By increasing the sampling frequency, both open-loop and closed-loop overall noise can be reduced significantly. The interface circuit has more than 120 dB dynamic range and can resolve better than 10 aF. The complete module operates from a single 5-V supply and has a measured sensitivity of 960 mV/g with a noise floor of 1.08 /spl mu/g//spl radic/Hz in open-loop. This system can resolve better than 10 /spl mu/g//spl radic/Hz in closed-loop.