Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging

Aging causes a progressive decline in the structure and function of organs. With advancing age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of developing vascular dysfunction and cardiovascular diseases, including hypertension, diabetes, atherosclerosis, and neurodegeneration. Senescent ECs undergo phenotypic changes that alter the pattern of expressed proteins, as well as their morphologies and functions, and have been linked to vascular impairments, such as aortic stiffness, enhanced inflammation, and dysregulated vascular tone. Numerous molecules and pathways, including sirtuins, Klotho, RAAS, IGFBP, NRF2, and mTOR, have been implicated in promoting EC senescence. This review summarizes the molecular players and signaling pathways driving EC senescence and identifies targets with possible therapeutic value in age-related vascular diseases.     

Effects of relatedness and number of distractors on attribute judgments in Alzheimer's disease.

Participants made judgments about the relative salience of category exemplars (e.g., fruit: apple or grape) or parts (e.g., plane: wings or seats). Mildly affected Alzheimer's disease (AD) patients were as accurate but slower than normal controls, and their response times increased more for related (e.g., apple, grape, or fig) than unrelated (e.g., apple, gym, bandit) choices as the number of alternatives was increased from 2 to 3. Performance (accuracy and response times) of moderate-severely affected patients was poorer still, but number of distractors and relatedness did not interact. In combination with previous findings (e.g., M. K. Johnson, A. M. Hermann, & J. L. Bonilla, 1995), these results suggest that the reflective processes necessary for deciding among competing alternatives show disruption early in the disease process. Such processing deficits would compound any difficulties arising from a degrading semantic structure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A determination of the products of reaction betweer various sulfide minerals and aqueous xanthate solution,and a correlation of the products with electrode rest potentials

The surface reaction products formed when sulfide minerals react with xanthates were analyzed by spectrophotometric methods. These products were found to be predominantly either metal xanthate or dixanthogen, depending on the particular sulfide mineral. Dixanthogen is formed on those minerals that, in a solution of xanthate, assume a rest potential greater than the equilibrium potential for the reduction of dixanthogen or xanthate.     

Personality changes following transorbital lobotomy.

From the Rorschach findings presented, it can be inferred that "transorbital lobotomy results in a lessening of inner tension, a lessening of introspective self-awareness and insight, and a loss of ardent enthusiasm and active interest." A significant increase in W% is interpreted as some change in apperception. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Synthesis and characterization of in situ anionically polymerized p-aminobenzoylcaprolactam using di-and tri-functional initiator systems

Summary p-Aminobenzoylcaprolactam has been polymerized anionically in a two-step process to produce aramide-amide copolymers. Both drawn fibers and unoriented films may be produced using this method. The samples were characterized using FTIR, solution NMR, thermal analysis, viscosity, and mechanical testing. FTIR and NMR revealed the incorporation of both the aramid and amide linkages into the polymer backbone. TGA results gave a lower decomposition temperature than that of both aramide and nylon 6 materials. Intrinsic viscosities averaged 0.5 dL/g for the drawn copolymer samples polymerized by the di-functional initiator. Light microscopy displayed crystalline domains that did not appear to melt even up to 300°C. Mechanical testing showed that the initial moduli of drawn fiber samples to be in the range of 30–80 MPa, while homopolymers of nylon 6 and p-benzamide possessed values of 25 MPa and 2.70×10³ MPa, respectively.