Opioids in treatment of chronic noncancer pain

Opioids have been accepted as appropriate analgesic treatment for pain associated with cancer. However, controversy exists about their use for chronic noncancer pain. Reasons for reluctance are concerned about efficacy and potential adverse effects such as respiratory depression, addiction, physical dependence or intolerance. Many physicians worry about liability and legal restrictions. Nevertheless, pain management of chronic severe pain with opioids can be the only help when alternative methods are too risky of fail to be effective. This article briefly reviews the published literature on this topic and discusses some practical guidelines for the use of opioids in the treatment of non-cancer pain.     

Increased oxidation of LDL in patients with coronary artery disease is independent from dietary vitamins E and C

There is increasing experimental evidence that oxidation of LDL plays a major role in the pathogenesis of coronary artery disease (CAD). However, results from clinical studies on LDL oxidation and CAD are not consistent. In most studies only single plasma factors of LDL oxidation have been determined. We studied 207 patients who underwent coronary angiography. They were divided into subjects with CAD (n = 137) and those without CAD (n = 70). We determined the susceptibility of LDL to in vitro oxidation (lag phase), potential prooxidative and antioxidative plasma factors (plasma vitamin E, LDL vitamin E, ascorbate, iron, copper, ferritin, and ceruloplasmin), and markers of in vivo LDL oxidation (autoantibodies to malondialdehyde-modified LDL, oxidized LDL, and thiobarbituric acid-reactive substances), plasma lipids and lipoproteins, smoking habits, and other coronary risk factors in both groups. The lag phase was significantly shorter in patients with CAD than in patients without CAD (101 +/- 38.6 versus 119 +/- 40.6 minutes, P < .01). There was no correlation between the lag phase and the other oxidation parameters or the coronary risk factors. In multivariate regression analyses the lag phase remained significant in all tested models. Our data suggest that a short lag phase of LDL oxidation might be an independent risk factor of CAD.     

On-Line and Off-Line Approximation Algorithms for Vector Covering Problems

This paper deals with vector covering problems in d -dimensional space. The input to a vector covering problem consists of a set X of d -dimensional vectors in [0,1] ^d . The goal is to partition X into a maximum number of parts, subject to the constraint that in every part the sum of all vectors is at least one in every coordinate. This problem is known to be NP-complete, and we are mainly interested in its on-line and off-line approximability. For the on-line version, we construct approximation algorithms with worst case guarantee arbitrarily close to 1/(2d) in d≥ 2 dimensions. This result contradicts a statement of Csirik and Frenk in [5] where it is claimed that, for d≥ 2 , no on-line algorithm can have a worst case ratio better than zero. Moreover, we prove that, for d≥ 2 , no on-line algorithm can have a worst case ratio better than 2/(2d+1) . For the off-line version, we derive polynomial time approximation algorithms with worst case guarantee Θ(1/ log d) . For d=2 , we present a very fast and very simple off-line approximation algorithm that has worst case ratio 1/2 . Moreover, we show that a method from the area of compact vector summation can be used to construct off-line approximation algorithms with worst case ratio 1/d for every d≥ 2 . Received November 1996; revised March 1997.     

Developing a Combustion Model of a Solid Propellant Containing Capsules of Liquid Oxidizer

A combustion model of a solid propellant containing liquid oxidizer capsules was developed. The model is based on the combustion cycle of a unit cell, an oxidizer droplet surrounded by the adjusting amount of binder. Three combustion stages are considered: (1) binder decomposition parallel to oxidizer heating up to boiling temperature, (2) simultaneous binder and oxidizer gasification, and (3) gasification of the remaining condensed phase species. Simple global kinetics are assumed for the gas phase reactions and binder decomposition abiding Arrhenius law, and boiling process for the oxidizer abiding Clausius‐Clapeyron curves. The obtained results show similar trends as do other relevant models and experimental results, especially for the effect of droplet size and propellant composition on the burn rate. The predicted effect of initial temperature on the burn rate is less significant than for common solid propellants. The results indicate that for small droplets the oxidizer will heat up to boiling temperature even before it is revealed on the burning surface, due to heat conduction through the surrounding binder.     

Single‐source multibattery solar charger: case study and implementation issues

In this paper, design process and functionality of a portable single‐panel dual‐battery solar charger prototype are presented, achieving energy density of 571 W h kg⁻¹ during a typical 3‐day infantry mission. The device may instantaneously charge up to two Li‐ion MR‐2791 batteries, supporting plug‐and‐play operation. The system consists of a lightweight custom solar panel, based on 20% efficient monocrystalline photovoltaics, and an intelligent power processing module. The panel contains eight transparent polymer‐encapsulated and camouflaged series‐connected six solar cell packs with antiparallel diodes, allowing partial shading operation. The power processing module consists of two synchronous current‐mode‐controlled buck converters, digital signal processor, and a microcontroller, supporting both maximum power point tracking of the solar panel with partial shading detection and multimode charging of Li‐ion packs while instantaneously communicating with the batteries. Power management algorithmic design is presented, based on ensuring system stability while supporting the required operation modes. System implementation stages and underlying issues are thoroughly discussed, and utilized hardware components are presented in detail. Experimental results of system testing under real outdoor conditions are presented to demonstrate the device functionality and energy yield capabilities. Copyright © 2015 John Wiley & Sons, Ltd.     

Public-Coin Parallel Zero-Knowledge for NP

We show that, assuming the existence of collision-resistant hash functions, every language in NP has a constant-round public-coin zero-knowledge argument that remains secure under unbounded parallel composition (a.k.a. parallel zero knowledge.) Our protocol is a variant of Barak’s zero-knowledge argument (FOCS 2001), and has a non-black-box simulator. This result stands in sharp contrast with the recent result by Pass, Tseng and Wikstrom (Crypto 2010) showing that only languages in BPP have public-coin parallel zero-knowledge arguments with black-box simulators.     

Input Locality and Hardness Amplification

We establish new hardness amplification results for one-way functions in which each input bit influences only a small number of output bits (a.k.a. input-local functions). Our transformations differ from previous ones in that they approximately preserve input locality and at the same time retain the input size of the original function. Let f:{0,1} ⁿ →{0,1} ^m be a one-way function with input locality d, and suppose that f cannot be inverted in time $\exp(\tilde{O}(\sqrt{n}\cdot d))$ on an ε-fraction of inputs. Our main results can be summarized as follows:

• If f is injective then it is equally hard to invert f on a (1?ε)-fraction of inputs.
• If f is regular then there is a function g:{0,1} ⁿ →{0,1} ^m+O(n) that is d+O(log³ n) input local and is equally hard to invert on a (1?ε)-fraction of inputs.

A natural candidate for a function with small input locality and for which no sub-exponential time attacks are known is Goldreich’s one-way function. To make our results applicable to this function, we prove that when its input locality is set to be d=O(logn) certain variants of the function are (almost) regular with high probability. In some cases, our techniques are applicable even when the input locality is not small. We demonstrate this by extending our first main result to one-way functions of the “parity with noise” type.     

A Dichotomy for Local Small-Bias Generators

We consider pseudorandom generators in which each output bit depends on a constant number of input bits. Such generators have appealingly simple structure: They can be described by a sparse input–output dependency graph \(G\) and a small predicate \(P\) that is applied at each output. Following the works of Cryan and Miltersen (MFCS’01) and by Mossel et al (STOC’03), we ask: which graphs and predicates yield “small-bias” generators (that fool linear distinguishers)? We identify an explicit class of degenerate predicates and prove the following. For most graphs, all non-degenerate predicates yield small-bias generators, \(f:\{0,1\}^n \rightarrow \{0,1\}^m\), with output length \(m = n^{1 + \epsilon }\) for some constant \(\epsilon > 0\). Conversely, we show that for most graphs, degenerate predicates are not secure against linear distinguishers, even when the output length is linear \(m=n+\Omega (n)\). Taken together, these results expose a dichotomy: Every predicate is either very hard or very easy, in the sense that it either yields a small-bias generator for almost all graphs or fails to do so for almost all graphs. As a secondary contribution, we attempt to support the view that small-bias is a good measure of pseudorandomness for local functions with large stretch. We do so by demonstrating that resilience to linear distinguishers implies resilience to a larger class of attacks.     

Study of hydrogen production and storage based on aluminum–water reaction

The rate and yield of hydrogen production from the reaction between activated aluminum and water has been investigated. The effect of different parameters such as water–aluminum ratio, water temperature and aluminum particle size and shape was studied experimentally. The aluminum activation method developed in-house involves 1%–2.5% of lithium-based activator which is diffused into the aluminum particles, enabling sustained reaction with tap water or sea water at room temperature. Hydrogen production rates in the range of 200–600 ml/min/g Al, at a yield of about 90%, depending on operating parameters, were demonstrated. The work further studied the application in proton exchange membrane (PEM) fuel cells in order to generate green electric energy, demonstrating theoretical specific electric energy storage that can exceed batteries by 10–20 folds.     

Digital Circuit Design Trends

This paper has described the different trends in the digital circuit design and changes over the past two decades moving from chips that contained tens of thousands of devices to today' s chips that may contain over a billion transistors. The job of the digital circuit designer has grown with the chips, moving from optimizing and validating gates, to working on functional units, to now designing complete systems. While the progress in digital design has clearly been tremendous, power challenges are an important issue in future VLSI designing system. Designers used considerable ingenuity to make CMOS compatible with the older bipolar ECL/TTL families, concentrating on meeting all aspects of the without requiring external components.