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排序方式: 共有2979条查询结果,搜索用时 46 毫秒
31.
32.
Amir Mohammadzadeh Pter P. Lakatos Mihly Balogh Ferenc Zdor Dvid rpd Kardi Zoltn S. Zdori Kornl Kirly Anna Rita Galambos Szilvia Barsi Pl Riba Sndor Benyhe Lszl Kles Tams Tbi va Szk Laszlo G. Harsing Jr. Mahmoud Al-Khrasani 《International journal of molecular sciences》2021,22(5)
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP. 相似文献
33.
Barimani Samaneh Amini Amir Chaharmahali Iman 《Journal of Computational Electronics》2021,20(3):1332-1342
Wave absorbers are considered to be fundamental building blocks for the manipulation of light. Almost all optical systems exploit absorbers to realize some functions. A highly tunable wide-band THz absorber is presented herein. Utilizing a dual-bias scheme with a single graphene layer leads to greater freedom to control the absorption response, while a conventional periodic array of graphene ribbons and a layer of graphene sheet are also exploited. Also, a circuit model representation for all the constituent parts of the proposed absorber is developed with an evolved design methodology. According to the simulation results, wide-band absorption from 3.5 to 6 THz is achieved.
相似文献34.
Kevin Munoz Samiksha Wasnik Amir Abdipour Hongzheng Bi Sean M. Wilson Xiaolei Tang Mahdis Ghahramanpouri David J. Baylink 《International journal of molecular sciences》2021,22(10)
Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study aimed to develop a therapy to normalize the excess production of inflammatory cytokines and promote tissue repair in the lipopolysaccharide (LPS)-induced ALI. Based on our previous studies, we tested the insulin-like growth factor I (IGF-I) and BTP-2 therapies. IGF-I was selected, because we and others have shown that elevated inflammatory cytokines suppress the expression of growth hormone receptors in the liver, leading to a decrease in the circulating IGF-I. IGF-I is a growth factor that increases vascular protection, enhances tissue repair, and decreases pro-inflammatory cytokines. It is also required to produce anti-inflammatory 1,25-dihydroxyvitamin D. BTP-2, an inhibitor of cytosolic calcium, was used to suppress the LPS-induced increase in cytosolic calcium, which otherwise leads to an increase in proinflammatory cytokines. We showed that LPS increased the expression of the primary inflammatory mediators such as toll like receptor-4 (TLR-4), IL-1β, interleukin-17 (IL-17), TNF-α, and interferon-γ (IFN-γ), which were normalized by the IGF-I + BTP-2 dual therapy in the lungs, along with improved vascular gene expression markers. The histologic lung injury score was markedly elevated by LPS and reduced to normal by the combination therapy. In conclusion, the LPS-induced increases in inflammatory cytokines, vascular injuries, and lung injuries were all improved by IGF-I + BTP-2 combination therapy. 相似文献
35.
Amir Hamzeh Haghiabi 《Water Resources Management》2017,31(3):811-824
Modeling river mixing mechanism in terms of pollution transmission in rivers is an important subject in environmental studies. Dispersion coefficient is an important parameter in river mixing problem. In this study, to model and predict the longitudinal dispersion coefficient (D L ) in natural streams, two soft computing techniques including multivariate adaptive regression splines (MARS) as a new approach to study hydrologic phenomena and multi-layer perceptron neural network as a common type of neural network model were prepared. To this end, related dataset were collected from literature and used for developing them. Performance of MARS model was compared with MLP and the empirical formula was proposed to calculate D L . To define the most effective parameters on D L structure of obtained formula from MARS model and more accurate formula was evaluated. Calculation of error indices including coefficient of determination (R2) and root mean square error (RMSE) for the results of MARS model showed that MARS model with R2?=?0.98 and RMSE?=?0.89 in testing stage has suitable performance for modeling D L . Comparing the performance of empirical formulas, ANN and MARS showed that MARS model is more accurate compared to others. Attention to the structure of developed MARS and the most accurate empirical formulas model showed that flow velocity, depth of flow (H) and shear velocity are the most influential parameters on D L . 相似文献
36.
Carlo Ghezzi Claudio Menghi Amir Molzam Sharifloo Paola Spoletini 《Requirements Engineering》2014,19(3):231-255
Software development processes have been evolving from rigid, pre-specified, and sequential to incremental, and iterative. This evolution has been dictated by the need to accommodate evolving user requirements and reduce the delay between design decision and feedback from users. Formal verification techniques, however, have largely ignored this evolution and even when they made enormous improvements and found significant uses in practice, like in the case of model checking, they remained confined into the niches of safety-critical systems. Model checking verifies if a system’s model \(\mathcal{M}\) satisfies a set of requirements, formalized as a set of logic properties \(\Phi\) . Current model-checking approaches, however, implicitly rely on the assumption that both the complete model \(\mathcal{M}\) and the whole set of properties \(\Phi\) are fully specified when verification takes place. Very often, however, \(\mathcal{M}\) is subject to change because its development is iterative and its definition evolves through stages of incompleteness, where alternative design decisions are explored, typically to evaluate some quality trade-offs. Evolving systems specifications of this kind ask for novel verification approaches that tolerate incompleteness and support incremental analysis of alternative designs for certain functionalities. This is exactly the focus of this paper, which develops an incremental model-checking approach for evolving Statecharts. Statecharts have been chosen both because they are increasingly used in practice natively support model refinements. 相似文献
37.
This paper addresses the problem of defining a simple End-Effector design for a robotic arm that is able to grasp a given set of planar objects. The OCOG (Objects COmmon Grasp search) algorithm proposed in this paper searches for a common grasp over the set of objects mapping all possible grasps for each object that satisfy force closure and quality criteria by taking into account the external wrenches (forces and torque) applied to the object. The mapped grasps are represented by feature vectors in a high-dimensional space. This feature vector describes the design of the gripper. A database is generated for all possible grasps for each object in the feature vector space. A search algorithm is then used for intersecting all possible grasps over all parts and finding a common grasp suitable for all objects. The search algorithm utilizes the kd-tree index structure for representing the database of the sets of feature vectors. The kd-tree structure enables an efficient and low cost nearest-neighbor search for common vectors between the sets. Each common vector found (feature vector) is the grasp configuration for a group of objects, which implies the future end-effector design. The final step classifies the grasps found to subsets of the objects, according to the common vectors found. Simulations and experiments are presented for four objects to validate the feasibility of the proposed algorithm. The algorithm will be useful for standardization of end-effector design and reducing its engineering time. 相似文献
38.
Ali Rezaee Amir Masoud Rahmani Ali Movaghar Mohammad Teshnehlab 《The Journal of supercomputing》2014,67(2):345-383
In cloud computing, services play key roles. Services are well defined and autonomous components. Nowadays, the demand of using Fuzzy inference as a service is increasing in the domain of complex and critical systems. In such systems, along with the development of the software, the cost of detecting and fixing software defects increases. Therefore, using formal methods, which provide clear, concise, and mathematical interpretation of the system, is crucial for the design of these Fuzzy systems. To obtain this goal, we introduce the Fuzzy Inference Cloud Service (FICS) and propose a novel discipline for formal modeling of the FICS. The FICS provides the service of Fuzzy inference to the consumers. We also introduce four novel formal verification tests, which allow strict analysis of certain behavioral disciplines in the FICS as follows: (1) Internal consistency, which analyzes the service in a strict and delicate manner; (2) Deadlock freeness; (3) Divergence freeness; and (4) Goal reach ability. The four tests are discussed and the FICS is verified to ensure that it can pass all these tests. 相似文献
39.
Temperature-dependent diffusion coefficient of soluble substances during ethanol extraction of clove
San Myint Wan Ramli Wan Daud Abu Bakar Mohamad Abdul Amir H. Kadhum 《Journal of the American Oil Chemists' Society》1996,73(5):603-610
The temperature dependence of the diffusion coefficient of ethanol-soluble substances from ground cloves (particle size 250
μm) during extraction was estimated by fitting batch extraction data at several temperatures (27.8, 40, 50, and 60°C) to a
previously developed mass transfer model. The model was based on spherical geometry of particles. Nonlinear regression analysis
was used to develop an equation that describes the diffusivity as a function of temperature. The temperature dependence ofD
A
was of the Arrhenius type. 相似文献
40.