Near infrared light-induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol

Light-sensitive drug delivery systems are considered ideal for applications in the biomedical fields for their ability to release the payload in an on-demand spatiotemporal controlled manner through the manipulation of the light source. Among the broad radiation spectrum, near infrared (NIR) light is considered advantageous compared to UV and visible light, due to its inherently lower photodamage to normal tissues and deeper penetration to lesion areas. In this study, we report a successful synthesis of a polymer capable of undergoing partial degradation upon irradiation with NIR light by conjugating 10-N-carbamoyl linkage methylene blue (MB) moiety, a NIR photocleavable ligand, with polyethylene glycol (PEG). Through effective coupling of MB, a hydrophobic moiety, to the hydrophilic PEG molecule, an amphiphilic polymer was synthesized, as demonstrated by a lowered surface tension (55 mN/m at 0.1% wt/vol). Subsequently, photo-induced reversal of surface activity associated with self-assembled structure disruption, was displayed by surface tension measurements, size distribution analysis, and burst release profile of paclitaxel (PTX) from polymeric micelles upon the exposure to NIR irradiation.     

Multi-objective reactive power market clearing in competitive electricity market using HFMOEA

This paper presents an application of a hybrid fuzzy multi-objective evolutionary algorithm (HFMOEA) for solving a highly constraint, mixed integer type, complex multi-objective reactive power market clearing (RPMC) problem for the competitive electricity market environment. In HFMOEA based multi-objective optimization approach, based on the output of a fuzzy logic controller crossover and mutation probabilities are varied dynamically. It enhances stochastic search capabilities of HFMOEA. In multi-objective RPMC optimization framework, two objective functions namely the total payment function (TPF) for reactive power support from generators and synchronous condensers and the total real transmission loss (TRTL) are minimized simultaneously for clearing the reactive power market. The proposed HFMOEA based multi-objective RPMC scheme is tested on a standard IEEE 24 bus reliability test system and its performance is compared with five other multi-objective evolutionary techniques such as MOPBIL, NSGA-II, UPS-EMOA and SPEA-2 and a new extended form of NSGA (ENSGA-II). Applying all these six evolutionary techniques, a detailed statistical analysis using T-test and boxplots is carried out on three performance metrics (spacing, spread and hypervolume) data for RPMC problem. The obtained simulation results confirm the overall superiority of HFMOEA to generate better Pareto-optimal solutions with higher convergence rate as compared to above mentioned algorithms. Further, TPF and TRTL values corresponding to the best compromise solutions are obtained using said multi-objective evolutionary techniques. These values are compared with one another to take better market clearing decisions in competitive electricity environment.     

On semantic annotation of decision models

The growth of service sector in recent years has led to renewed research interests in the design and management of service systems. Decision support systems (DSS) play an important role in supporting this endeavor, through management of organizational resources such as models and data, thus forming the “back stage” of service systems. In this article, we identify the requirements for semantically annotating decision models and propose a model representation scheme, termed Semantically Annotated Structure Modeling Markup Language (SA-SMML) that extends Structure Modeling Markup Language (SMML) by incorporating mechanisms for linking semantic models such as ontologies that represent problem domain knowledge concepts. This model representation format is also amenable to a scalable Service-Oriented Architecture (SOA) for managing models in distributed environments. The proposed model representation technique leverages recent advances in the areas of semantic web, and semantic web services. Along with design considerations, we demonstrate the utility of this representation format with an illustrative usage scenarios with a particular emphasis on model discovery and composition in a distributed environment.     

A methodology to incorporate product mix variations in cellular manufacturing

The identification of part families and machine groups that form the cells is a major step in the development of a cellular manufacturing system and, consequently, a large number of concepts, theories and algorithms have been proposed. One common assumption for most of these cell formation algorithms is that the product mix remains stable over a period of time. In today’s world, the market demand is being shaped by consumers resulting in a highly volatile market. This has given rise to a new class of products characterized by low volume and high variety. To incorporate product mix changes into an existing cellular manufacturing system many important issues have to be tackled. In this paper, a methodology to incorporate new parts and machines into an existing cellular manufacturing system has been presented. The objective is to fit the new parts and machines into an existing cellular manufacturing system thereby increasing machine utilization and reducing investment in new equipment.     

Emotion Recognition From Facial Expressions and Its Control Using Fuzzy Logic

This paper presents a fuzzy relational approach to human emotion recognition from facial expressions and its control. The proposed scheme uses external stimulus to excite specific emotions in human subjects whose facial expressions are analyzed by segmenting and localizing the individual frames into regions of interest. Selected facial features such as eye opening, mouth opening, and the length of eyebrow constriction are extracted from the localized regions, fuzzified, and mapped onto an emotion space by employing Mamdani-type relational models. A scheme for the validation of the system parameters is also presented. This paper also provides a fuzzy scheme for controlling the transition of emotion dynamics toward a desired state. Experimental results and computer simulations indicate that the proposed scheme for emotion recognition and control is simple and robust, with good accuracy.     

Investigations on mode-division multiplexed free-space optical transmission for inter-satellite communication link

Wireless Networks - Inter-satellite data transmission links are very crucial for providing global inter-connectivity. We report designing and investigations on high date rate inter-satellite...     

Modulated Triple‐Material Nano‐Heterostructures: Where Gold Influenced the Chemical Activity of Silver in Nanocrystals

For efficient charge separations, multimaterial hetero‐nanostructures are being extensively studied as photocatalysts. While materials with one heterojunction are widely established, the chemistry of formation of multijunction heterostructures is not explored. This needs a more sophisticated approach and modulations. To achieve these, a generic multistep seed mediated growth following controlled ion diffusion and ion exchange is reported which successfully leads to triple‐material hetero‐nanostructures with bimetallic‐binary alloy‐binary/ternary semiconductors arrangements. Ag₂S nanocrystals are used as primary seeds for obtaining AuAg‐AuAgS bimetallic‐binary alloyed metal–semiconductor heterostructures via partial reduction of Ag(I) using Au(III) ions. These are again explored as secondary seeds for obtaining a series of triple‐materials heterostructures, AuAg‐AuAgS‐CdS (or ZnS or AgInS₂), with introduction of different divalent and trivalent ions. Chemistry of each step of the gold ion–induced changes in the rate of diffusion and/or ion exchanges are investigated and the formation mechanism for these nearly monodisperse triple material heterostructures are proposed. Reactions without gold are also performed, and the change in the reaction chemistry and growth mechanism in presence of Au is also discussed.     

FSE–Ag complex NS: preparation and evaluation of antibacterial activity

Silver (Ag) complexes of drugs and their nanosystems have great potential as antibacterials. Recently, an Ag complex of furosemide (Ag–FSE) has shown to be a promising antimicrobial. However, poor solubility of Ag–FSE could hamper its introduction into clinics. Therefore, the authors developed a nanosuspension of Ag–FSE (Ag–FSE_NS) for its solubility and antibacterial activity enhancement. The aim of this study was to introduce a novel nanoantibiotic with enhanced antibacterial efficacy. Ag–FSE_NS was prepared by precipitation–ultrasonication technique. Size, polydispersity index (PI) and zeta potential (ZP) of prepared Ag–FSE_NS were measured by dynamic light scattering, whereas surface morphology was determined using scanning electron microscopy (SEM). In vitro antibacterial activity was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa using broth microdilution method. Size, PI and ZP of optimised Ag–FSE_NS1 were 191.2 ± 19.34 nm, 0.465 ± 0.059 and −55.7 ± 8.18 mV, respectively. SEM revealed that Ag–FSE_NS1 particles were rod or needle‐like with smooth surfaces. Saturation solubility of Ag–FSE in NS increased eight‐fold than pure Ag–FSE. Ag–FSE_NS1 exhibited two‐fold and eight‐fold enhancements in activity against E. coli and S. aureus, respectively. The results obtained showed that developed Ag–FSE_NS1 holds a promise as a topical antibacterial.Inspec keywords: nanomedicine, nanofabrication, light scattering, surface morphology, silver, particle size, solubility, suspensions, scanning electron microscopy, electrokinetic effects, drugs, biomedical materials, antibacterial activity, microorganisms, nanoparticles, drug delivery systems, transmission electron microscopyOther keywords: saturation solubility, topical antibacterial, size 171.86 nm to 210.54 nm, voltage ‐47.52 mV to ‐63.88 mV, Ag, broth microdilution method, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, SEM, scanning electron microscopy, surface morphology, dynamic light scattering, particle size, polydispersity index, precipitation–ultrasonication technique, nanoantibiotic, nanosuspension, furosemide, nanosystems, drugs, Ag–FSE_NS preparation, in vitro antibacterial activity, pure Ag–FSE, Ag–FSE_NS1 particles, optimised Ag–FSE_NS1, zeta potential, enhanced antibacterial efficacy, antibacterials     

Roadmap for the next generation of dynamic function allocation theories and strategies

Dynamic function allocation theories have matured, but not to the extent that they can be implemented in actual environments. The authors identify a roadmap to help to get to that stage, after a brief review of relevant function allocation theories and the gaps in knowledge in adaptive allocation theories. Past research has focused on short‐term implementations of dynamic function allocation, which last for minutes (but never more than a few hours). Stable and enduring implementations of dynamic function allocation, lasting over days or possibly years, require a better and scientific understanding of the interaction among trigger mechanisms, adaptation strategies, and interruption strategies. The possibility of an unintentional consequence of this adaptive allocation, that the automated agent becomes confined to limited levels of automation, has to be ruled out after experimental evidence. © 2010 Wiley Periodicals, Inc.