PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study

Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.     

职业教育深化产教融合的系统基模分析

职业教育进入提质培优新阶段,以深化产教融合助推职业教育高质量发展,是落实科教兴国战略和人才强国战略的必修课.基于对产教融合生态系统的内涵和困境分析,运用系统基模解构职业院校产教融合生态的运行机制,并提出相应的管理策略,对深化职业教育产教融合具有重要指导意义.     

EFFECTS OF SPECIFIED BLANK SIZE ON BODY WRINKLING DURING HYDRODYNAMIC DEEP DRAWING OF TAPERED RECTANGULAR BOX

1.~nonHydridapawhcdeepdrawing(HDD)belongstothefieldofsheetmetalfoeingandcanbeaPPliedinthefieldofautomotive,aerospace,drilitaryindustryetc.Ithasbeenrecognizedwidelyintheworld["'j.Fig.Ishowsitsprinciple:TheliqUidthatisfilledinthe~ngdiecavitywillbepressedwhenthepunchgoesdownsothattheeffectoffrictionkeepingandoverflowlubricatingcanbeformed,astherestilt,thefoeinglicitofsheetmetalwillbeimprovedareailvandthegualitVofthefinishedpartswillbeup~ed.BecauseofmanyadvantagesofHDDprocees,ithasbeenwidelys…     

微量稀土和硼在铜及其合金中的作用

介绍了近年来微量稀土和硼在其合金中的应用，稀土在铜和铜合金中去除杂质，净化晶界，细化组织，消除柱状晶的作用，从而改善铜和铜合金的导电性，力学性能，冷热加工性能和耐磨性性能，硼在铜和铜合金中有比稀土更显著的细化晶粒作用。     

低冲击条件下凝聚炸药延迟起爆现象的研究进展

描述了凝聚炸药在低强度冲击作用下的延迟现象XTD介绍并分析研究XDT现象的试验和数值模拟方法，提出了XDT研究的发展方向。     

Structure-oriented rational design of chymotrypsin inhibitor models

Three peptides modelling a highly potent, 35-residue chymotrypsininhibitor (Schistocerca gregaria chymotrypsin inhibitor) weredesigned and synthesized by convergent peptide synthesis. Foreach model peptide, the inhibitory constant (K_i) on chymotrypsinand the solution structure were determined. In addition, moleculardynamics calculations were performed for all of them. Two modelscontaining approximately half of the parent inhibitor (17 of35 residues) were designed and subsequently found to have nosubstantial inhibitory activity (K_i values in the mM range).The third model composed of 24 amino acid residues proved tobe an effective (K_i 10^–7) inhibitor of bovine chymotrypsin.Both the solution structure properties determined by NMR spectroscopyand the dynamic behaviour of the latter model system are comparableto the native inhibitor. In contrast, the structure and dynamicsof the first two related model peptides show characteristicdifferences. We suggest that the conformation and flexibilityof the modelled protease inhibitor are crucial for its biologicalefficiency. Moreover, the structural and dynamic features ofthe binding loop (28–33) and those of the rest of themolecule appear to be interdependent. Most importantly, thesestructural characteristics can be rationally modified, at leastpartially, by peptide design. Received March 7, 2003; revised August 25, 2003; accepted August 26, 2003.     

纳米二氧化硅模板的制备

以微乳液法制备纳米二氧化硅（SiO2）粒子，经压制、烧结制备SiO2模板。通过红外（IR）、热分析（TGDTA）、扫描电镜（SEM）等方法对SiO2模板进行表征，结果表明所得SiO2粒度在100nm左右．烧结温度在800℃时，SiO2粒子之间将实现颈长，有利于有机／无机杂化多孔材料的制备。     

光活性二氧化钛涂层的研究与制备

本文介绍了制备光活性TiO2涂层的两种主要方法，并就一些影响因素进行了简单的讨论。     

轻量级PRESENT加密算法功耗攻击研究

PRESENT密码算法是2007年提出来的一种轻量级分组密码算法, 适合于物联网环境下的安全加密。对PRESENT加密算法结构进行了深入研究, 提出了其适合功耗攻击的两个最佳攻击点, 详细介绍了针对PRESENT加密系统进行功耗分析攻击的设计与实现过程, 实验结果表明未加防护措施的PRESENT加密系统不能抵御一阶差分功耗分析攻击, 从而给PRESENT加密算法的安全改进提供一定的设计参考。