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71.
72.
Jit Biswas Andrei Tolstikov Maniyeri Jayachandran Victor Foo Aung Aung Phyo Wai Clifton Phua Weimin Huang Louis Shue Kavitha Gopalakrishnan Jer-En Lee Philip Yap 《电信纪事》2010,65(9-10):505-521
Monitoring and timely intervention are extremely important in the continuous management of health and wellness among all segments of the population, but particularly among those with mild dementia. In relation to this, we prescribe three design principles for the construction of services and applications. These are ambient intelligence, service continuity, and micro-context. In this paper, we provide three exemplars from our research and development activities that illustrate the use of these design principles in the construction of services and applications. All the applications are drawn from the field of care for mild dementia patients in their living quarters. 相似文献
73.
Petru Andrei 《Journal of Computational Electronics》2006,5(4):315-318
A calibration method is developed for the electron effective mass in the Density-Gradient model. This method uses the two- and three-dimensional effective-mass Schrödinger equations, which are solved for bounded quantum systems. The electron effective mass is computed by fitting the electron concentration computed by using the Density-Gradient model to the electron concentration computed by using the Schrödinger equation. Results for strongly confined silicon system with (100), (110), and (111) crystallographic orientations are presented. It is shown that the effective mass varies with the shape and dimensions of the quantum box. In device simulations, one should use the value of m_n that corresponds to the right shape and dimensions of the confinement region in the device. 相似文献
74.
An automated technique is presented for the computation of the doping profiles that minimize the intrinsic fluctuations of
various parameters induced by random doping fluctuations in semiconductor devices. The technique is based on the computation
of the doping sensitivity functions of the parameters under consideration and the constrained minimization of the standard
deviation of fluctuations by using the Lagrange multipliers technique. The technique is then applied to the minimization of
the random doping induced fluctuations of the threshold voltage in 40-nm channel length MOSFET device. 相似文献
75.
Jaehyeon Kim Ezgi Bakirci Kelly L. O'Neill Andrei Hrynevich Paul D. Dalton 《大分子材料与工程》2021,306(3):2000685
Melt electrowriting (MEW) is a direct-writing technology for small diameter fibers; however, due to electrostatic attraction, the technique is restricted in how close these microfibers can be positioned on the collector. Here, the minimum interfiber distance between parallel poly(ε-caprolactone) MEW microfibers is determined for different fiber diameters and number of layers on noncoated and star-shaped poly(ethylene oxide-stat-propylene oxide) (sP(EO-stat-PO))-coated glass coverslips. The effect of the fiber diameter, the number of fiber layers, and shape of turning loops affect precision and the minimum interfiber distance. Single fibers with diameter of 5, 10, and 15 µm have a minimum interfiber distance without fiber bridging of 33 ± 2.7, 54 ± 2.2, and 62 ± 2.7 µm, respectively. Increasing the number of layers to ten increases this minimum interfiber distance approximately twofold to 60 ± 3.5, 97 ± 4.5, and 102 ± 2.7 µm for the increasing fiber diameters. The sP(EO-stat-PO) slightly increases the minimum interfiber distance for the 15 µm diameter group only, with spacing for the 5 and 10 µm fibers unaffected by the coating. Identifying and determining the fabrication limits for MEW is highly instructional for users working and designing scaffolds with this technology. 相似文献
76.
Vitalii Kim Emily Gudvangen Oleg Kondratiev Luis Redondo Shu Xiao Andrei G. Pakhomov 《International journal of molecular sciences》2021,22(13)
Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF (nsPEF) are less efficient at neurostimulation and can be employed to minimize such side effects. We quantified the impact of the electrode configuration, PEF strength (up to 20 kV/cm), repetition rate (up to 3 MHz), bi- and triphasic pulse shapes, and pulse duration (down to 10 ns) on eliciting compound action potentials (CAPs) in nerve fibers. The excitation thresholds for single unipolar but not bipolar stimuli followed the classic strength–duration dependence. The addition of the opposite polarity phase for nsPEF increased the excitation threshold, with symmetrical bipolar nsPEF being the least efficient. Stimulation by nsPEF bursts decreased the excitation threshold as a power function above a critical duty cycle of 0.1%. The threshold reduction was much weaker for symmetrical bipolar nsPEF. Supramaximal stimulation by high-rate nsPEF bursts elicited only a single CAP as long as the burst duration did not exceed the nerve refractory period. Such brief bursts of bipolar nsPEF could be the best choice to minimize neuromuscular stimulation in ablation therapies. 相似文献
77.
Cristina-Daniela Ghițulică Andreia Cucuruz Georgeta Voicu Andrei T. Cucuruz Sorina Dinescu Aida Selaru Marieta Costache 《International Journal of Applied Ceramic Technology》2020,17(1):342-353
In this study, chemical precipitation methods were used to obtain ceramic materials doped with magnesium ions in order to improve the regeneration properties of materials used for tissue engineering. Two different ratios of magnesium oxide were used to dope the ceramic powder, more precisely 5% and 10%. The synthesized materials were characterized to determine the calcination temperature of the precursor powder by means of thermal analysis; to determine the mineralogical composition, X-ray diffraction was employed and the scanning electron microscopy was used to determine the microstructure. To make use of these ceramics as biomaterials, viability and proliferation cell tests have been performed. Since synthetic materials have several limitations with regard to medical applications, the materials based on HAp substituted with Mg ions are a promising solution for the regeneration of bone defects because they have a similar bone structure. The presence of Mg in the material proves to be beneficial because this element plays an important role in bone cell regeneration, and more specifically, in stimulating osteoblast proliferation. The materials synthesized in this work present a suitable morphology for uses in bone regeneration because they offer to cells a friendly environment for growth and anchoring. 相似文献
78.
Andrei V. Igansi Jenifer Engelmann Sabrina F. Lütke Frederico B. Porto Luiz A. A. Pinto 《Chemical Engineering Communications》2019,206(11):1399-1413
AbstractThe aim of this work was to study the bleaching of oil extracted from the heads of the catfish by thermomechanical process through equilibrium, kinetics, and thermodynamics adsorption studies. The condition for the bleaching step was with 1% (w/w) adsorbent composed of 95% activated earth and 5% activated carbon (w/w). The pseudo-first order and pseudo-second order models were the most appropriate to represent the adsorption kinetics. The temperature of 80?°C increased the adsorption capacity of the two adsorbates, and the activation energies values were of 47.47 and 44.82?kJ mol?1, respectively, for the adsorption of carotenoids and peroxides. The Langmuir model was the most appropriate to describe the bleaching equilibrium curves. The thermodynamic parameters revealed that the processes were endothermic, favorable, and spontaneous and the interaction between adsorbent and adsorbate was physical. 相似文献
79.
Dr. Balamurugan Dhayalan Dr. Ann Fitzpatrick Dr. Kalyaneswar Mandal Dr. Jonathan Whittaker Prof. Dr. Michael A. Weiss Prof. Dr. Andrei Tokmakoff Prof. Dr. Stephen B. H. Kent 《Chembiochem : a European journal of chemical biology》2016,17(5):415-420
Isotope‐edited two‐dimensional Fourier transform infrared spectroscopy (2 D FTIR) can potentially provide a unique probe of protein structure and dynamics. However, general methods for the site‐specific incorporation of stable 13C=18O labels into the polypeptide backbone of the protein molecule have not yet been established. Here we describe, as a prototype for the incorporation of specific arrays of isotope labels, the total chemical synthesis—via a key ester insulin intermediate—of 97 % enriched [(1‐13C=18O)PheB24] human insulin: stable‐isotope labeled at a single backbone amide carbonyl. The amino acid sequence as well as the positions of the disulfide bonds and the correctly folded structure were unambiguously confirmed by the X‐ray crystal structure of the synthetic protein molecule. In vitro assays of the isotope labeled [(1‐13C=18O)PheB24] human insulin showed that it had full insulin receptor binding activity. Linear and 2 D IR spectra revealed a distinct red‐shifted amide I carbonyl band peak at 1595 cm?1 resulting from the (1‐13C=18O)PheB24 backbone label. This work illustrates the utility of chemical synthesis to enable the application of advanced physical methods for the elucidation of the molecular basis of protein function. 相似文献
80.
Fast Ray Tracing of Implicit Surfaces 总被引:1,自引:0,他引:1
Andrei Sherstyuk 《Computer Graphics Forum》1999,18(2):139-147
A ray-tracing algorithm is described for rendering implicit surfaces formed with C1 -continuous bounded functions f ( x , y , z ). This class of functions includes such popular implicit models as blobby molecules, metaballs, soft objects and convolution surfaces. The algorithm employs analytical methods only, which makes it fast, robust, and numerically stable.
An earlier version of this work was presented at the 3rd International Workshop on Implicit Surfaces held in Seattle in 1998. 相似文献
An earlier version of this work was presented at the 3rd International Workshop on Implicit Surfaces held in Seattle in 1998. 相似文献