A Guard Code Scheme for Handover Traffic Management in WCDMA Systems

A key performance indicator of mobile wireless networks is failure probability of handover calls. In this paper, we propose a Call Admission Control policy which prioritizes handover calls over new calls in WCDMA systems. The OVSF code occupancy of the system is modeled by a Markov chain and the differentiation between handover and new calls is performed at the code level by introducing a “guard code” scheme. The scheme belongs to the well-known family of guard channel schemes and reserves some code capacity to favor the continuation of handover calls over the new calls. As the management of the general case is intractable, we solve certain numerical instances of the problem and manage to calculate several performance metrics like new call blocking and handover failure probabilities and code utilization. We complete our study with simulation results in the case of higher OVSF code tree capacity.

A Semi-Parametric Non-linear Neural Network Filter: Theory and Empirical Evidence

In this work, we decompose a time series into trend and cycle by introducing a novel de-trending approach based on a family of semi-parametric artificial neural networks. Based on this powerful approach, we propose a relevant filter and show that the proposed trend specification is a global approximation to any arbitrary trend. Furthermore, we prove formally a famous claim by Kydland and Prescott (1981, 1997) that over long time periods, the average value of the cycles is zero. A simple procedure for the econometric estimation of the model is developed as a seven-step algorithm, which relies on standard techniques, where all relevant measures may be computed routinely. Next, using relevant DGPs, we compare and show by means of Monte Carlo simulations that our approach is superior to Hodrick–Prescott (HP) and Baxter and King (BK) regarding the generated distortionary effects and the ability to operate in various frequencies, including changes in volatility, amplitudes and phase. In fact, while keeping the structure of the model relatively simple, our approach is perfectly capable of addressing the case of stochastic trend, in the sense that the generated distortionary effects in the near unit root case are minimal and, by all means, considerably fewer than those generated by HP and BK. Application to EU15 business cycles clustering is presented and the empirical results are consistent with the rigorous theoretical framework developed in this work.     

Tensor splines for interpolation and approximation of DT-MRI with applications to segmentation of isolated rat hippocampi

In this paper, we present novel algorithms for statistically robust interpolation and approximation of diffusion tensors-which are symmetric positive definite (SPD) matrices-and use them in developing a significant extension to an existing probabilistic algorithm for scalar field segmentation, in order to segment diffusion tensor magnetic resonance imaging (DT-MRI) datasets. Using the Riemannian metric on the space of SPD matrices, we present a novel and robust higher order (cubic) continuous tensor product of B-splines algorithm to approximate the SPD diffusion tensor fields. The resulting approximations are appropriately dubbed tensor splines. Next, we segment the diffusion tensor field by jointly estimating the label (assigned to each voxel) field, which is modeled by a Gauss Markov measure field (GMMF) and the parameters of each smooth tensor spline model representing the labeled regions. Results of interpolation, approximation, and segmentation are presented for synthetic data and real diffusion tensor fields from an isolated rat hippocampus, along with validation. We also present comparisons of our algorithms with existing methods and show significantly improved results in the presence of noise as well as outliers.     

Liquid Biopsy: A New Translational Diagnostic and Monitoring Tool for Musculoskeletal Tumors

Soft tissue and bone sarcomas represent a group of aggressive neoplasms often accompanied by dismal patient prognosis, especially when distant metastases are present. Moreover, effective treatment can pose a challenge, as recurrences are frequent and almost half of patients present with advanced disease. Researchers have unveiled the molecular abnormalities implicated in sarcomas’ carcinogenesis, paving the way for novel treatment strategies based on each individual tumor’s characteristics. Therefore, the development of new techniques aiding in early disease detection and tumor molecular profiling is imperative. Liquid biopsy refers to the sampling and analysis of patients’ fluids, such as blood, to identify tumor biomarkers, through a variety of methods, including qRT-PCR, qPCR, droplet digital PCR, magnetic microbeads and digital PCR. Assessment of circulating tumor cells (CTCs), circulating free DNA (ctDNA), micro RNAs (miRs), long non-coding RNAs (lncRNAs), exosomes and exosome–associated proteins can yield a plethora of information on tumor molecular signature, histologic type and disease stage. In addition, the minimal invasiveness of the procedure renders possible its wide application in the clinical setting, and, therefore, the early detection of the presence of tumors. In this review of the literature, we gathered information on biomarkers assessed through liquid biopsy in soft tissue and bone sarcoma patients and we present the information they can yield for each individual tumor type.     

A molecular perspective of water at metal interfaces

Water/solid interfaces are relevant to a broad range of physicochemical phenomena and technological processes such as corrosion, lubrication, heterogeneous catalysis and electrochemistry. Although many fields have contributed to rapid progress in the fundamental knowledge of water at interfaces, detailed molecular-level understanding of water/solid interfaces comes mainly from studies on flat metal substrates. These studies have recently shown that a remarkably rich variety of structures form at the interface between water and even seemingly simple flat surfaces. In this Review we discuss the most exciting work in this area, in particular the emerging physical insight and general concepts about how water binds to metal surfaces. We also provide a perspective on outstanding problems, challenges and open questions.     

Energy efficient network coding-based MAC for cooperative ARQ wireless networks

In this paper we introduce a network coding-aided energy efficient Medium Access Control (MAC) protocol that coordinates the transmissions among a set of relay nodes which act as helpers in cooperative Automatic Repeat reQuest-based (ARQ-based) wireless networks. Applying network coding techniques, we achieve to increase the energy efficiency of the network without compromising the system performance in terms of Quality of Service. Our proposed solution is evaluated by both analytical and simulation results.     

Capability-Based Defenses Against DoS Attacks in Multi-path MANET Communications

We present the design, implementation, and evaluation of CapMan, a capability-based security mechanism that prevents denial-of-service (DoS) attacks against mobile ad-hoc networks (MANETs). In particular, our approach is designed to mitigate insider attacks that exploit multi-path routing to flood with packets on other participating nodes in the network. CapMan is instantiated on every node and enforces capability limits that effectively regulate the traffic for all end-to-end network flows. Each capability is issued and advertised by the capability distribution module, and is globally maintained via the capability enforcement logic. By periodically exchanging small usage summaries, all cooperating nodes are informed of the global network state in a scalable and consistent manner. The distribution of summaries empowers individual nodes to make informed decisions and regulate traffic as dictated by the per-flow capabilities across multiple dynamic routing paths. We implemented a prototype of CapMan as a module of the NS2 simulator. We conducted extensive simulations with the prototype using AOMDV as the underlying multi-path routing protocol. Both theoretical analysis and experimental results validate that our mechanism can effectively curtail sophisticated DoS attacks that target multi-path routing in MANETs. We can protect the overall network health even when both the initiator and the responder are malicious insiders and collude in an attempt to deprive the network of valuable resources. Finally, our results show that CapMan introduces relatively small and configurable network overhead and imposes minimal impact on non-attacking traffic flows.     

The EPH/Ephrin System in Bone and Soft Tissue Sarcomas’ Pathogenesis and Therapy: New Advancements and a Literature Review

Musculoskeletal sarcomas represent rare heterogenous malignancies of mesenchymal origin that can be divided in two distinct subtypes, bone and soft tissue sarcomas. Current treatment options combine the surgical excision of local tumors and multidrug chemotherapy to prevent metastatic widespread disease. Due to the grim prognosis that usually accompanies such tumors, researchers have attempted to shed light on the molecular pathways implicated in their pathogenesis in order to develop novel, innovative, personalized therapeutic strategies. Erythropoietin-producing human hepatocellular receptors (EPHs) are tyrosine-kinase transmembrane receptors that, along with their ligands, ephrins, participate in both tumor-suppressive or tumor-promoting signaling pathways in bone and soft tissue sarcomas. The EPH/ephrin axis orchestrates cancerous processes such as cell–cell and cell–substrate adhesion and enhances the remodeling of the intracellular cytoskeleton to stimulate the motility and invasiveness of sarcoma cells. The purpose of our study was to review published PubMed literature to extract results from in vitro, in vivo and clinical trials indicative of the role of EPH/ephrin signaling in bone and soft tissue sarcomas. Based on these reports, significant interactions between the EPH/ephrin signaling pathway and a plethora of normal and abnormal cascades contribute to molecular mechanisms enhancing malignancy during sarcoma progression. In addition, EPHs and ephrins are prospective candidates for diagnostic, monitoring and therapeutic purposes in the clinical setting against bone and soft tissue sarcomas.