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61.
Steven S Fu Miles McFall Andrew J Saxon Jean C Beckham Timothy P Carmody Dewleen G Baker Anne M Joseph 《Nicotine & tobacco research》2007,9(11):1071-1084
We conducted a systematic review of what is known about the relationship between post-traumatic stress disorder (PTSD) and smoking to guide research on underlying mechanisms and to facilitate the development of evidence-based tobacco treatments for this population of smokers. We searched Medline, PsychINFO, and the Cochrane Central Register of Controlled Trials and identified 45 studies for review that presented primary data on PTSD and smoking. Smoking rates were high among clinical samples with PTSD (40%-86%) as well as nonclinical populations with PTSD (34%-61%). Most studies showed a positive relationship between PTSD and smoking and nicotine dependence, with odds ratios ranging between 2.04 and 4.52. Findings also suggest that PTSD, rather than trauma exposure itself, is more influential for increasing risk of smoking. A small but growing literature has examined psychological factors related to smoking initiation and maintenance and the overlapping neurobiology of PTSD and nicotine dependence. Observational studies indicate that smokers with PTSD have lower quit rates than do smokers without PTSD. Yet a few tobacco cessation treatment trials in smokers with PTSD have achieved quit rates comparable with controlled trials of smokers without mental disorders. In conclusion, the evidence points to a causal relationship between PTSD and smoking that may be bidirectional. Specific PTSD symptoms may contribute to smoking and disrupt cessation attempts. Intervention studies that test behavioral and pharmacological interventions designed specifically for use in patients with PTSD are needed to reduce morbidity and mortality in this population. 相似文献
62.
HM Chaung CH Hong CP Chiang SK Lin YS Kuo WH Lan CC Hsieh 《Canadian Metallurgical Quarterly》1996,95(7):545-550
This review reports the different genetic factors that have been identified either as risk factor for Alzheimer's disease (AD) or directly causing the disease. First are reviewed epidemiological data and biological mechanisms about the apoplipoprotein E gene allele epsilon 4 that is a major risk factor for Alzheimer's disease. The second part describes the mutations responsible for early-onset autosomal dominant AD found in three different genes. The gene located on chromosome 21 encodes the amyloid precusor protein (APP). The presenilin 1 and presenilin 2 genes, located on chromosome 14 and 1 respectively, encode not yet known membrane proteins. 相似文献
63.
Anne J. Kershen 《Landscape Research》2004,29(3):261-275
For hundreds of years Spitalfields, the 250 acres that border the London Borough of Tower Hamlets and the City of London, has been a first point of settlement for immigrants. Its tradition of political and religious non-conformity and its proximity to the City of London and the docks have acted as a unique beacon to those seeking refuge and economic opportunity in a capital city. Spitalfields has provided a landscape upon which the incomers have engraved a 'home away from home', for themselves and their families. Using the 'Spitalfields experience' as a focal point, the concept and construction of home by migrants in the diaspora is explored, and some of the cultural tools that the Huguenots, eastern European Jews and Bangladeshis—the protagonist subject groups of this essay—have used to construct their homes in the elsewhere are examined. Due to the spatial limitations of this work, language, diet and religion have been selected as the topics under the microscope. All three facilitated the maintenance of links with the sending societies whilst, in some, though not in every instance, creating a bridge to assimilation. The usage and effectiveness of these tools is compared and contrasted and the role played by Spitalfields over the past four centuries in the creation of homes by those in an alien environment is assessed. 相似文献
64.
65.
AJ Conrad EY Chiang LE Andeen C Avolio SM Walker RW Baumhefner R Mirzayan WW Tourtellotte 《Canadian Metallurgical Quarterly》1994,54(1-2):99-108
A method for quantitating specific anti-viral antibodies in serum and cerebrospinal fluid (CSF) is established using enzyme-linked immunosorbent assay (ELISA). Quantitated antibody levels are used to determine intrathecal specific IgG synthesis rate for the particular antibody. Measles virus was used as a model for validating this quantitative technique: a mutated form of measles virus is a cause of subacute sclerosing panencephalitis (SSPE) and there is a possibility that measles virus is related to the cause of multiple sclerosis (MS). Matched serum and CSF samples were assayed. Concentration of anti-measles IgG was determined and intrathecal measles-specific IgG synthesis rate was calculated. For the SSPE samples, measles-specific IgG synthesis rate was elevated and comprised > 20% of the total intrathecal IgG synthesis rate; these results are consistent with the literature. The ELISA method can be performed routinely, providing a quick, simple, reproducible means of quantitating specific antibody concentrations, with sensitivity greater than 1 nanogram per milliliter. With this method, quantitation of IgG antibodies to any other viral antigen can be reliably and precisely determined. 相似文献
66.
By using optical displacement-measuring techniques we obtain the crack tip fields in terms of crack tip strain, crack opening angle (COA) and crack tip opening angle (CTOA). Thin plates with different crack configurations made of six elastic-plastic materials with strain hardening exponent ranging from 3 to are studied. We find that the COA resistance curve assumes certain characteristics common to all the materials. The experimental results indicate that the critical value of COA may be used as a fracture toughness parameter for these materials.
Résumé En utilisant une technique de mesure optique des déplacements, on obtient les champs régnant à l'estrémité d'une entaille, qui s'experiment par la déformation d'extrémité d'entaille, l'angle d'ouverture de la crique (COA et l'angle d'ouverture de la pointe de la crique (CTOA). On étudie des feuillards présentant différentes configurations de fissures et réalisés en six matériaux élasto-plastiques dont les modules d'écrouissage s'échelonnent de 3 à l'infini.On trouve que la courbe de résistance COA suppose certaines caractéristiques communes à tous les matériaux. Les résultats expérimentaux indiquent que la valeur critique du COA peut être utilisée comme paramètre de ténacité à la rupture pour les matériaux étudiés.相似文献
67.
In this paper, we develop a framework of Question Answering Pages (referred to as QA pages) recommendation. Our proposed framework consists of the two modules: the off-line module to determine the importance of QA pages and the on-line module for on-line QA page recommendation. In the off-line module, we claim that the importance of QA pages could be discovered from user click streams. If the QA pages are of higher importance, many users will click and spend their time on these QA pages. Moreover, the relevant relationships among QA pages are captured by the browsing behavior on these QA pages. As such, we exploit user click streams to model the browsing behavior among QA pages as QA browsing graph structures. The importance of QA pages is derived from our proposed QA browsing graph structures. However, we observe that the QA browsing graph is sparse and that most of the QA pages do not link to other QA pages. This is referred to as a sparsity problem. To overcome this problem, we utilize the latent browsing relations among QA pages to build a QA Latent Browsing Graph. In light of QA latent browsing graph, the importance score of QA pages (referred to as Latent Browsing Rank) and the relevance score of QA pages (referred to as Latent Browsing Recommendation Rank) are proposed. These scores demonstrate the use of a QA latent browsing graph not only to determine the importance of QA pages but also to recommend QA pages. We conducted extensive empirical experiments on Yahoo! Asia Knowledge Plus to evaluate our proposed framework. 相似文献
68.
Anne Grethe Christophersen Grete Bertelsen Henrik J. Andersen Pia Knuthsen Leif H. Skibsted 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1992,194(2):115-119
Summary The combined effect of oxygen transmission of packaging material and of exposure to light with different spectral distribution on the oxidative degradation of carotenoids and lipids in frozen salmonoids has been characterized in a storage experiment with steaks of rainbow trout. The degradation of the carotenoid astaxanthin, as followed by HPLC analysis and tristimulus colorimetric measurement, was sensitive to the radiant flux density of UV light and less sensitive to the oxygen transmission rate of the packaging material, in agreement with previous findings for photooxidation of carotenoids in food model systems. This is in contrast to the lipid oxidation, which was found to be dependent on the accessability of oxygen rather than on exposure to UV light. Formation of peroxides in the product culminated after 3 months of storage (up to 8.4 mEq kg–1 oil), and preceded the formation of thiobarbituric-acid-reactive substances. The product in packaging material with a high oxygen transmission rate (60 cm3 m–2 bar–1 per 24 h) reached a level of approximately 5 mol malonaldhyde/kg–1 product, when stored exposed to standard fluorescent light or fluorescent light with a high UV component. Rancid taste was not detected by sensory evaluation for any of the products after 6 months of storage, whereas a bitter taste was noted for the product exposed to UV light.
Die Haltbarkeit von Lachsforellen Einfluß von Licht und Verpackung auf die Carotenoid- und Fettoxydation
Zusammenfassung Der kombinierte Effekt von Sauerstoffdurchgang durch Verpackungsmaterial und der Lichteinwirkung verschiedener spektraler Verteilung auf den oxidativen Abbau der Carotinoide und Fette in gefrorenen Lachsforellen wurde in einem Lagerungsversuch untersucht. Der Abbau des Carotenoids Astaxanthin wurde mit HPLC undTristimulus-Calorimetrie beobachtet, und war empfindlich gegenüber UV-Licht und weniger empfindlich gegenüber der Sauerstoffdurchlässigkeit der Verpackung, was mit früheren Ergebnissen für Photooxidation der Carotinoide in Modellsystemen übereinstimmt. Dies widerspricht der Fettoxidation, die mehr von Sauerstoffzugang abhängig ist als von der Entwicklung des UV-Lichtes. Die Bildung von Peroxiden des Produktes kuliminierte nach 3monatiger Lagerung (bis 8,4 meq/kg Öl) und ging der Bildung von Thiobarbitursäure-aktiven Substanzen voraus. Das Produkt im Material mit hohem Sauerstoffdurchgang (60 cm3 m–2 bar–1 pro 24 h), das bei normalen fluorescierendem Licht oder bei fluorescierendem Licht mit hohem UV-Anteil aufbewahrt wurde, erreichte einen TBS-Wert von ungefähr 5 mol Malonaldehyd/kg Fleisch. Ein ranziger Geschmack wurde durch sensorische Bewertung nach 6monatiger Lagerung nicht erkannt, wohl aber ein bitterer Geschmack bei dem UV-Licht ausgesetzten Proben.相似文献
69.
dos Santos Tiago G. Silva Antonio O. S. Pedrosa Anne M. G. Araujo Antonio S. Souza Marcelo J. B. 《Journal of Porous Materials》2021,28(3):919-928
Journal of Porous Materials - Catalysts of AlMCM-48 with different Si/Al molar rations were synthesized by modified hydrothermal method with respect to previous works. As a consequence, the... 相似文献
70.
Francesca Truzzi Camilla Tibaldi Anne Whittaker Silvia Dilloo Enzo Spisni Giovanni Dinelli 《International journal of molecular sciences》2021,22(1)
There is a need to assess the relationship between improved rheological properties and the immunogenic potential of wheat proteins. The present study aimed to investigate the in vitro effects of total protein extracts from three modern and two landrace Triticum aestivum commercial flour mixes, with significant differences in gluten strength (GS), on cell lines. Cytotoxicity and innate immune responses induced by wheat proteins were investigated using Caco-2 monocultures, two dimensional (2D) Caco-2/U937 co-cultures, and three dimensional (3D) co-cultures simulating the intestinal mucosa with Caco-2 epithelial cells situated above an extra-cellular matrix containing U937 monocytes and L929 fibroblasts. Modern wheat proteins, with increased GS, significantly reduced Caco-2 cell proliferation and vitality in monoculture and 2D co-cultures than landrace proteins. Modern wheat proteins also augmented Caco-2 monolayer disruption and tight junction protein, occludin, redistribution in 3D co-cultures. Release of interleukin-8 into the cell medium and increased U937 monocyte migration in both 2D and 3D co-cultures were similarly apparent. Immuno-activation of migrating U937 cells was evidenced from cluster of differentiation 14 (CD14) staining and CD11b-related differentiation into macrophages. The modern wheat proteins, with gluten polymorphism relatedness and increased GS, were shown to be more cytotoxic and immunogenic than the landrace wheat proteins. 相似文献