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61.
Lapointe Nicolas P.; Ung Roth-Visal; Rouleau Pascal; Guertin Pierre A. 《Canadian Metallurgical Quarterly》2008,122(3):576
Experiments in completely spinal cord transected (Tx) cats have provided compelling evidence that clonidine combined with tail stimulation can promote locomotor function recovery. However, clonidine has generally failed to induce locomotor activity in other comparable animal models suggesting the existence of species- or condition-specific effects. This study aimed at investigating the effects of clonidine administered (0.25 or 5.0 mg/kg, i.p.) in mice during tail pinching in early (6-7 days post-Tx) or late (41-42 days post-Tx) paraplegic animals (Th9/10 level). Comparisons were made with the effects induced by 8-OH-DPAT (1.0 mg/kg, i.p.), a 5-HT1A/7 receptor agonist known to display prolocomotor effects. Clonidine with or without tail pinching failed to induce hind limb movements and even suppressed the frequency of spontaneously occurring nonlocomotor (NLM) and locomotor-like movements (LM) whereas tail pinching alone (prior to clonidine administration) increased the frequency of spontaneous movements specifically in late chronic animals. In turn, 8-OH-DPAT clearly induced hind limb movements that remained relatively unchanged during tail pinching. Altogether, the results suggest that the prolocomotor effects of clonidine reported elsewhere must depend upon stimuli or factors that remain to be identified. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
62.
Meckelein Barbara; Nikiforov Theo; Clemen Annette; Appelhans Heribert 《Protein engineering, design & selection : PEDS》1990,3(3):215-220
Human mucus proteinase inhibitor (MPI) consists of 107 aminoacids arranged in two domains showing high homology to eachother. This protein is an inhibitor of different serine proteinasesincluding trypsin, chymotrypsin, leukocyte elastase and cathepsinG. On the basis of sequence comparisons it has been suggestedthat the first domain inhibits trypsin, whereas the second onewas thought to be active against chymotrypsin and elastase.To prove the location of the different inhibitory activitiesgene fragments for both domains have been cloned separatelyand expressed in Escherichia coli. Inhibition assays with theisolated recombinant domains showed that the second domain isactive against chymotrypsin, neutrophil elastase and trypsin,whereas for the first domain only a weak activity against trypsincould be detected. These results suggest that the inhibitoryactivities of the native molecule towards these three proteinasesare all located in the second domain. 相似文献
63.
Berninghaus Siegfried K.; Güth Werner; Kirstein Annette 《Canadian Metallurgical Quarterly》2008,1(1):33
Systematic experiments with distribution games have shown that participants are strongly motivated by considerations of fairness and efficiency. This evidence, however, results mainly from experimental designs in which money is shared directly. Furthermore, fairness does not necessarily require equal payoffs, but may instead require equal allocations. We investigate experimentally the frame dependency of reaching equal (commodity or payoff) splits by systematically comparing net-trade proposals and payoff proposals for the same exchange economy with two traders, two commodities and multi-period negotiations. We can confirm the hypothesis that asking participants to allocate money directly, rather than more naturally via the allocation of commodities, is far from being harmless and likely overstates fairness and efficiency concerns. What is more, we try to apply the insights gained from our experiment to management problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
64.
Ulrich Reffle Annette Gotscharek Christoph Ringlstetter Klaus U. Schulz 《International Journal on Document Analysis and Recognition》2009,12(3):165-174
The detection and correction of false friends—also called real-word errors—is a notoriously difficult problem. On realistic
data, the break-even point for automatic correction so far could not be reached: the number of additional infelicitous corrections
outnumbered the useful corrections. We present a new approach where we first compute a profile of the error channel for the
given text. During the correction process, the profile (1) helps to restrict attention to a small set of “suspicious” lexical
tokens of the input text where it is “plausible” to assume that the token represents a false friend. In this way, recognition
of false friends is improved. Furthermore, the profile (2) helps to isolate the “most promising” correction suggestion for
“suspicious” tokens. Using a conventional word trigram statistics for disambiguation we obtain a correction method that can
be successfully applied to unrestricted text. In experiments for OCR documents, we show significant accuracy gains by fully
automatic correction of false friends. 相似文献
65.
In the testing of ocean wave energy devices, the demand for a portable and robust data acquisition and electrical loading system has become apparent. This paper investigates the development of a 30 kW inclusive system combining loading capabilities, real-time power analysis, and data acquisition for the testing of deployed ocean wave energy devices. Hardware results for ocean testing are included. 相似文献
66.
67.
O Déas C Dumont M MacFarlane M Rouleau C Hebib F Harper F Hirsch B Charpentier GM Cohen A Senik 《Canadian Metallurgical Quarterly》1998,161(7):3375-3383
We examined the effects of the cell-permeable, broad spectrum peptide caspase inhibitors, benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethyl ketone (Z-VAD.fmk), and BOC-Asp(OMe)-fluoromethyl ketone (BOC-D.fmk), on apoptosis induced by anti-CD2, anti-Fas, and the protein kinase inhibitor staurosporine in activated human peripheral T lymphocytes. We monitored ultrastructural, flow cytometric, and biochemical apoptotic changes, including externalization of phosphatidylserine, cleavage of poly(ADP-ribose) polymerase (PARP) and lamins, activation of caspase-3 and caspase-7, decrease in mitochondrial membrane potential, and DNA fragmentation. Z-VAD.fmk and BOC-D.fmk completely inhibited all the biochemical and ultrastructural changes of apoptosis in anti-Fas-treated cells. In marked contrast, neither Z-VAD.fmk nor BOC-D.fmk inhibited CD2- or staurosporine-mediated cell shrinkage, dilatation of the endoplasmic reticulum (seen in anti-CD2-treated cells), externalization of phosphatidylserine, and loss of mitochondrial membrane potential that accompanied cell death. However, these inhibitors did inhibit the cleavage of PARP and lamins and the formation of hypodiploid cells, and partially inhibited chromatin condensation. These results demonstrate that in activated T cells, anti-CD2 and staurosporine induce a caspase-independent cell death pathway that exhibits prominent cytoplasmic features of apoptosis. However, caspase activation is required for the proteolytic degradation of nuclear substrates such as PARP and lamins together with the DNA fragmentation and extreme chromatin condensation that occur in apoptotic cells. 相似文献
68.
The kinetics of the vapor phase oxidation of benzene has been studied over an industrial catalyst in a continuous stirred tank reactor in the temperature range from 280 to 430°C and at atmospheric pressure. The products obtained are maleic anhydride, carbon oxides and water. The rate of the overall reaction (disappearance of benzene) is represented by the following expression based upon a steady state adsorption model The rate of formation of maleic anhydride is correlated by the equation which allows for a homogeneous depletion of maleic anhydride. The rate constants kB, kO, k2(g) were found to follow Arrhenius behavior. 相似文献
69.
70.
Hansson J Båth M Håkansson M Grundin H Bjurklint E Orvestad P Kjellström A Boström H Jönsson M Jonsson K Månsson LG 《Radiation protection dosimetry》2005,114(1-3):278-285
The aim of this study was to find the optimum tube voltage for neonatal chest imaging in computed radiography. The study was designed to take full advantage of the benefits of digital imaging, for example, by comparing the tube voltages at constant effective dose. A phantom study using a living rabbit was first conducted. Images were collected at tube voltages ranging from 40 to 90 kV(p). The reproduction of four structures (central vessels, peripheral vessels, carina and thoracic vertebrae) was rated by 10 radiologists. The reproduction of both central and peripheral vessels was relatively independent of tube voltage. The carina was better reproduced at higher tube voltages whereas the opposite was true for the thoracic vertebrae. Based on the higher importance of the reproduction of the carina it was decided that 90 kV(p) was the optimal tube voltage. To validate the result from the phantom study, a follow-up study was conducted in which images of neonates collected at the tube voltage regularly used at Sahlgrenska University Hospital (70 kV(p)) were compared with images collected at the tube voltage proposed by the phantom study. The follow-up study confirmed the results from the phantom study that the reproduction of the carina was better at 90 than at 70 kV(p). In conclusion, for neonatal chest imaging-given the same effective dose-90 kVp gives better reproduction of important structures than the regularly used 70 kV(p). 相似文献