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111.
112.
Hukun Yang Hongyuan Jiang Antonio Ramos Pablo García-Sánchez 《Microfluidics and nanofluidics》2009,7(6):767-772
AC electro-osmotic (ACEO) pumping is experimentally demonstrated on a symmetric gold electrode array. Using asymmetric connection
of electrodes to the applied AC voltage, spatial asymmetry along the array is created, which produces unidirectional flow
of electrolyte. An aqueous solution of 100 μM KCl is selected as the pumping fluid. The liquid velocity obtained as a function
of voltage and frequency is compared to that generated using travelling-wave electroosmosis (TWEO) with the same electrode
array. The expected velocities from the linear electrokinetic models of ACEO and TWEO are computed numerically. The comparison
shows that TWEO generates greater velocity amplitudes and the streamlines are smoother than those generated by ACEO. 相似文献
113.
Jairo Rocha de Faria Antonio A. Novotny 《Structural and Multidisciplinary Optimization》2009,39(6):547-555
The topological derivative provides the sensitivity of a given shape functional with respect to an infinitesimal (non smooth)
domain perturbation at an arbitrary point of the domain. Classically, this derivative comes from the second term of the topological
asymptotic expansion, dealing only with infinitesimal perturbations. However, for practical applications, we need to insert
perturbations of finite size. Therefore, we consider one more term in the expansion which is defined as the second order topological
derivative. In order to present these ideas, in this work we calculate first as well as second order topological derivatives
for the total potential energy associated to the Laplace’s equation, when the domain is perturbed with a hole. Furthermore,
we also study the effects of different boundary conditions on the hole: Neumann and Dirichlet (both homogeneous). In the Neumann’s
case, the second order topological derivative depends explicitly on higher-order gradients of the state solution and also
implicitly on the point where the hole is nucleated through the solution of an auxiliary problem. On the other hand, in the
Dirichlet’s case, the first order topological derivative depends explicitly on the state solution as well as implicitly through
the solution of an auxiliary problem, and the second order topological derivative depends only explicitly on the solution
associated to the original problem. Finally, we present two simple examples showing the influence of both terms in the second
order topological asymptotic expansion for each case of boundary condition on the hole. 相似文献
114.
The life sciences have sprouted several popular and successful OMICS technologies that span all levels of biological information transfer. Ever since the start of the Human Genome Project, the then revolutionary idea to make all resulting data publicly available has been central to all of the efforts across OMICS technologies. As a result, a great variety of publicly available data repositories and resources is currently available to the research community. This widespread availability of data does come at the price of increased confusion on the part of the users, especially for those that see the OMICS technologies as tools to help unravel a larger biological or clinical question. We therefore provide a comprehensive overview of the available resources across OMICS fields, with a special emphasis on those databases that are relevant to the study of proteins. Additionally, we also describe various integrative systems that have been established, and highlight new developments in the field that can revolutionize the way in which live data integration is achieved over the internet. 相似文献
115.
Anti-reflective (AR) boundary conditions (BC) have been introduced recently in connection with fast deblurring algorithms,
both in the case of signals and images. Here we extend such BCs to d dimensions (d ≥ 1) and we study in detail the algebra induced by the AR-BCs, with strongly symmetric point spread functions (PSF), both
from a structural and computational point of view. The use of the re-blurring idea and the computational features of the AR-algebra
allow us to apply Tikhonov-like techniques within O(n
d
log(n)) arithmetic operations, where n
d
is the number of pixels of the reconstructed object. Extensive numerical experimentation concerning 2D images and strongly
symmetric PSFs confirms the effectiveness of our proposal.
相似文献
116.
In this paper we present two tests which can decide whether a given pointx
0
N
is locally efficient or not with respect to a given finite set of real valued continuously differentiable functions defined on
N
. Examples indicate that the tests may fail on a nowhere dense set. 相似文献
117.
Antonio Balena Marco Bianco Ferruccio Pisanello Massimo De Vittorio 《Advanced functional materials》2023,33(39):2211773
Two-Photon Lithography, thanks to its very high sub-diffraction resolution, has become the lithographic technique par excellence in applications requiring small feature sizes and complex 3D pattering. Despite this, the fabrication times required for extended structures remain much longer than those of other competing techniques (UV mask lithography, nanoimprinting, etc.). Its low throughput prevents its wide adoption in industrial applications. To increase it, over the years different solutions have been proposed, although their usage is difficult to generalize and may be limited depending on the specific application. A promising strategy to further increase the throughput of Two-Photon Lithography, opening a concrete window for its adoption in industry, lies in its combination with holography approaches: in this way it is possible to generate dozens of foci from a single laser beam, thus parallelizing the fabrication of periodic structures, or to engineer the intensity distribution on the writing plane in a complex way, obtaining 3D microstructures with a single exposure. Here, the fundamental concepts behind high-speed Two-Photon Lithography and its combination with holography are discussed, and the literary production of recent years that exploits such techniques is reviewed, and contextualized according to the topic covered. 相似文献
118.
Nhan Dai Thien Tram Jian Xu Devika Mukherjee Antonio Eduardo Obanel Venkatesh Mayandi Vanitha Selvarajan Xiao Zhu Jeanette Teo Veluchamy Amutha Barathi Rajamani Lakshminarayanan Pui Lai Rachel Ee 《Advanced functional materials》2023,33(5):2210858
Bacterial trapping using nanonets is a ubiquitous immune defense mechanism against infectious microbes. These nanonets can entrap microbial cells, effectively arresting their dissemination and rendering them more vulnerable to locally secreted microbicides. Inspired by this evolutionarily conserved anti-infective strategy, a series of 15 to 16 residue-long synthetic β-hairpin peptides is herein constructed with the ability to self-assemble into nanonets in response to the presence of bacteria, enabling spatiotemporal control over microbial killing. Using amyloid-specific K114 assay and confocal microscopy, the membrane components lipoteichoic acid and lipopolysaccharide are shown to play a major role in determining the amyloid-nucleating capacity as triggered by Gram-positive and Gram-negative bacteria respectively. These nanonets displayed both trapping and killing functionalities, hence offering a direct improvement from the trap-only biomimetics in literature. By substituting a single turn residue of the non-amyloidogenic BTT1 peptide, the nanonet-forming BTT1-3A analog is produced with comparable antimicrobial potency. With the same sequence manipulation approach, BTT2-4A analog modified from BTT2 peptide showed improved antimicrobial potency against colistin-resistant clinical isolates. The peptide nanonets also demonstrated robust stability against proteolytic degradation, and promising in vivo efficacy and biosafety profile. Overall, these bacteria-responsive peptide nanonets are promising clinical anti-infective alternatives for circumventing antibiotic resistance. 相似文献
119.
Muscetti Michela Rinaldi Antonio M. Russo Cristiano Tommasino Cristian 《Knowledge and Information Systems》2022,64(5):1283-1303
Knowledge and Information Systems - The rapid increase of available data in different complex contexts needs automatic tasks to manage and process contents. Semantic Web technologies represent the... 相似文献
120.
Ortega-Cabezas Pedro Miguel Colmenar-Santos Antonio Borge-Diez David Blanes-Peiró Jorge Juan Higuera-Pérez Jorge Alcaide Eric 《Software Quality Journal》2022,30(3):687-728
Software Quality Journal - The number of electronic control units (ECU) installed in vehicles is increasingly high. Manufacturers must improve the software quality and reduce cost by proposing... 相似文献