Characteristics of Tableted Roselle (Hibiscus sabdariffa Linn.) with Addition of Sodium Starch Glycolate

The focus of this research is to study the characteristics of tablets produced from the binary powder mixture of Roselle (Hibiscus sabdariffa Linn.) and sodium starch glycolate (SSG) powders. The experimental parameters studied were the compaction pressure and the mass composition. The findings indicated that the increase of compaction pressure increased the tensile strength of tablets until a limiting value was reached. On the other hand, as the compaction pressure increased, the porosity of tablets decreased to a minimum value. The elastic recovery of tablets slightly decreased in some results. The increase in compaction pressure also increased the dissolution time of tablets up to a maximum value. The increase of SSG composition decreased the tensile strength of tablets to a certain amount. The dissolution time of tablets also reduced when the percentage of SSG increased. Subsequently, under the same compaction conditions, the increase of SSG composition increased the porosity and the elastic recovery of tablets until the limiting values were achieved.     

An Overview into Polyethylene Terephthalate (PET) Hydrolases and Efforts in Tailoring Enzymes for Improved Plastic Degradation

Plastic or microplastic pollution is a global threat affecting ecosystems, with the current generation reaching as much as 400 metric tons per/year. Soil ecosystems comprising agricultural lands act as microplastics sinks, though the impact could be unexpectedly more far-reaching. This is troubling as most plastic forms, such as polyethylene terephthalate (PET), formed from polymerized terephthalic acid (TPA) and ethylene glycol (EG) monomers, are non-biodegradable environmental pollutants. The current approach to use mechanical, thermal, and chemical-based treatments to reduce PET waste remains cost-prohibitive and could potentially produce toxic secondary pollutants. Thus, better remediation methods must be developed to deal with plastic pollutants in marine and terrestrial environments. Enzymatic treatments could be a plausible avenue to overcome plastic pollutants, given the near-ambient conditions under which enzymes function without the need for chemicals. The discovery of several PET hydrolases, along with further modification of the enzymes, has considerably aided efforts to improve their ability to degrade the ester bond of PET. Hence, this review emphasizes PET-degrading microbial hydrolases and their contribution to alleviating environmental microplastics. Information on the molecular and degradation mechanisms of PET is also highlighted in this review, which might be useful in the future rational engineering of PET-hydrolyzing enzymes.     

Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events

Homocysteine is a risk factor for atherosclerosis in the general population, and serum homocysteine levels are almost universally elevated in chronic renal failure patients. When such patients are treated with dialysis, cardiovascular disease accounts for more than 50% of their mortality, which, in some proportion, may be pathophysiologically related to the elevated serum homocysteine levels. From April 2003 to March 2005, we conducted a 2-year, double-blind, randomized, placebo-controlled trial of 186 patients with end-stage kidney disease due to any cause, who were older than 18 years and stable on hemodialysis. Patients were assigned to receive either oral folic acid 10 mg 3 times a week immediately after every dialysis session under nurse supervision or an identical-appearing placebo for the entire study. On admission, plasma total homocysteine (tHcy) levels were above 13.9 micromol/L in 96.7% of patients (median 25.0 micromol/L, range 9.3-104.0 micromol/L). In the placebo group, tHcy levels remained elevated at 6, 12, and 24 months, while oral folate significantly decreased tHcy to a median value of 10.5 (2.8-20.3) micromol/L, (p<0.01). During the study, 38 patients (folic acid group 17 vs. placebo group 21; p=0.47) died from cardiovascular disease. Kaplan-Meier life table analysis dealing with the incidence of cardiovascular events, both fatal and nonfatal (myocardial infarction, arrhythmias, angina, heart failure, cerebrovascular accident), showed that 2 years of folic acid treatment and the lowering of the homocysteine blood levels had no effect on cardiovascular events (p=0.41; hazard ratio 1.24, 95% CI 0.74-2.10). However, the carotid artery intima-media wall thickness measured in a blinded fashion decreased from 1.94 +/- 0.59 mm to 1.67 +/- 0.38 mm (p<0.01) after 2 years of folate therapy. In this short-term study of uremic patients, 2 years of folic acid supplementation normalized the tHcy blood levels in 92.3% of patients but did not change the incidence of cardiovascular events compared with the control group. However, ultrasonography of the common carotid arteries performed at entry and 24 months later showed a significant decrease in intima-media thickness with folate supplementation. This suggests that early folate supplementation may benefit patients with chronic renal failure by preventing cardiovascular deterioration.     

Stagnation point flow towards a stretching/shrinking sheet in a micropolar fluid with a convective surface boundary condition

The problem of a steady laminar two‐dimensional stagnation point flow towards a stretching/shrinking sheet in a micropolar fluid with a convective surface boundary condition is studied. The governing partial differential equations are transformed into ordinary differential equations using a similarity transformation, before being solved numerically using the Runge–Kutta–Fehlberg method with shooting technique. The effects of the material parameter and the convective parameter on the fluid flow and heat transfer characteristics are disscussed. It is found that the skin friction coefficient and the heat transfer rate at the surface decrease with increasing values of the material parameter. Moreover, dual solutions are found to exist for the shrinking case, while for the stretching case, the solution is unique. © 2011 Canadian Society for Chemical Engineering     

5–11 GHz CMOS PA with 158.9 ± 41 ps group delay and low power using current-reused technique

This paper proposes the design of a low group delay and low power ultra-wideband (UWB) power amplifier (PA) in 0.18 μm CMOS technology. The PA design employs two stages cascade with inductive peaking technique to provide broad bandwidth characteristic and higher gain while gain flatness can be achieved by connecting inter-stage circuit. A common gate current-reused technique is adopted at the first stage amplifier to achieve good input matching, low group delay and low power. The simulation results show that the proposed PA design has an average gain of 11.5 dB with flatness of ±0.4 dB from 5–11 GHz, while maintaining bandwidth of 4.2–12.3 GHz. An input return loss (S₁₁) less than −10.4 dB and output return loss (S₂₂) less than −9.5 dB, respectively are obtained. The PA design achieves excellent phase linearity (i.e., group delay variation) of ±41 ps and only consuming 17 mW power from 1.2 V supply voltage. A good output 1-dB compression point OP1 dB of 3.7 dBm is obtained. By using this method, the proposed design has low group delay variation and lowest power among the recently reported UWB CMOS PAs applications.     

An Overview of Audio Event Detection Methods from Feature Extraction to Classification

Audio streams, such as news broadcasting, meeting rooms, and special video comprise sound from an extensive variety of sources. The detection of audio events including speech, coughing, gunshots, etc. leads to intelligent audio event detection (AED). With substantial attention geared to AED for various types of applications, such as security, speech recognition, speaker recognition, home care, and health monitoring, scientists are now more motivated to perform extensive research on AED. The deployment of AED is actually a more complicated task when going beyond exclusively highlighting audio events in terms of feature extraction and classification in order to select the best features with high detection accuracy. To date, a wide range of different detection systems based on intelligent techniques have been utilized to create machine learning-based audio event detection schemes. Nevertheless, the preview study does not encompass any state-of-the-art reviews of the proficiency and significances of such methods for resolving audio event detection matters. The major contribution of this work entails reviewing and categorizing existing AED schemes into preprocessing, feature extraction, and classification methods. The importance of the algorithms and methodologies and their proficiency and restriction are additionally analyzed in this study. This research is expanded by critically comparing audio detection methods and algorithms according to accuracy and false alarms using different types of datasets.     

Spectral discrimination of healthy and Ganoderma-infected oil palms from hyperspectral data

Although hyperspectral remote sensing has been used to study many agricultural phenomena such as crop stress and diseases, the potential use of this technique for detecting Ganoderma disease infestations and damage to oil palms under field conditions has not been explored to date. This research was conducted to investigate the feasibility of using a portable hyperspectral remote-sensing instrument to identify spectral differences between oil-palm leaves with and without Ganoderma infections. Reflectance spectra of samples representative of three classes of disease severity were collected. The most significant bands for spectral discrimination were selected from reflectance spectra and first derivatives of reflectance spectra. The significant wavelengths were identified using one-way analysis of variance. Then, a Jeffries–Matusita (JM) distance measurement was used to determine spectral separability between the classes. A maximum likelihood classifier method was used to classify the three classes based on the most significant wavelength spectral responses, and an error matrix was finally used to assess the accuracy of the classification.     

Melting heat transfer in boundary layer stagnation-point flow towards a stretching/shrinking sheet in a micropolar fluid

The steady boundary layer stagnation-point flow of a micropolar fluid towards a horizontal linearly stretching/shrinking sheet is investigated. A mathematical model is developed to study the heat transfer characteristics occurring during the melting process due to a stretching/shrinking sheet. The transformed non-linear ordinary differential equations governing the flow are solved numerically by the Runge–Kutta–Fehlberg method with shooting technique. It is found that dual solutions exist for the shrinking case, while for the stretching case, the solution is unique.