Fernando Romero and Armando Ramos of Fernando Romero EnterprisE (FREE) describe how the firm's design for an iconic museum in Mexico City, which adopted complex computational techniques, required them to develop an integrated and highly collaborative approach to design; with a central digital 3-D model being applied throughout the construction phase. 相似文献
The new half‐sandwich scorpionate complexes [hydridotris(1‐pyrazolyl)methane]vanadium trichloride, ([VCl3{HC(pz)3}] 1 (pz=pyrazolyl), [tris(1‐pyrazolyl)methanesulfonate]vanadium trichloride, [VCl3{SO3C(pz)3}] 2 , [hydrido(1‐pyrazolyl)methane]iron dichloride, [FeCl2{HC(pz)3}] 3 , lithium [tris(1‐pyrazolyl)methanesulfonate]dichloroferrate, Li[FeCl2{SO3C(pz)3}] 4 , and [tris(1‐pyrazolyl)methanesulfonate]copper chloride, [CuCl{SO3C(pz)3}] 5 were synthesized, characterized and shown to act, as well as the related (tripyrazolylmethane)copper dichloride, [CuCl2{HC(pz)3}] 6 , as selective catalysts (or catalyst precursors) for the peroxidative oxidation (with hydrogen peroxide) of cyclohexane to cyclohexanol and cyclohexanone, under mild conditions (at room temperature and using an aqueous solution of H2O2). The iron complexes are the most active ones (reaching TON values up to ca. 690), the effects of a variety of factors are reported and the reaction is shown to proceed via both C‐ and O‐centred radical mechanisms, conceivably involving a metal‐based oxidant. 相似文献
The aim of this paper is to extend the conversation about the correlation between collaboration and citation impact in articles in Information Science & Library Science journals by analyzing this correlation’s behavior using a power scaling law approach. 28,131 articles that received 215,693 citations were analyzed. The number of these articles that were published through collaboration accounts for 69%. In general, the scaling exponent of multi-authored articles, both international and domestic, increases over time while the exponent of single-authored papers decreases. The citation impact and collaboration patterns exhibit a power law correlation with a scaling exponent of 1.34 ± 0.02. Citations to multi-authored articles increased \(2^{1.34}\) or 2.53 times each time the number of multi-authored papers doubled. The Matthew Effect is stronger for multi-authored papers than for single-authored. The scaling exponent for the power law relationship of domestic multi-authored papers was 1.35 ± 0.02. The citations to domestic multi-authored articles increased \(2^{1.35}\) or 2.55 times each time the number of domestic multi-authored articles doubled. Contrary to previous studies we found that the Matthew Effect is stronger for domestic multi-authored papers than for international multi-authored ones. 相似文献
Recently distributed real-time database systems are intended to manage large volumes of dispersed data. To develop distributed real-time data processing, a reality and stay competitive well defined protocols and algorithms must be required to access and manipulate the data. An admission control policy is a major task to access real-time data which has become a challenging task due to random arrival of user requests and transaction timing constraints. This paper proposes an optimal admission control policy based on deep reinforcement algorithm and memetic algorithm which can efficiently handle the load balancing problem without affecting the Quality of Service (QoS) parameters. A Markov decision process (MDP) is formulated for admission control problem, which provides an optimized solution for dynamic resource sharing. The possible solutions for MDP problem are obtained by using reinforcement learning and linear programming with an average reward. The deep reinforcement learning algorithm reformulates the arrived requests from different users and admits only the needed request, which improves the number of sessions of the system. Then we frame the load balancing problem as a dynamic and stochastic assignment problem and obtain optimal control policies using memetic algorithm. Therefore proposed admission control problem is changed to memetic logic in such a way that session corresponds to individual elements of the initial chromosome. The performance of proposed optimal admission control policy is compared with other approaches through simulation and it depicts that the proposed system outperforms the other techniques in terms of throughput, execution time and miss ratio which leads to better QoS.
Fritillaria bulbs are used in Traditional Chinese Medicine to treat several illnesses. Peimine (Pm), an anti-inflammatory compound from Fritillaria, is known to inhibit some voltage-dependent ion channels and muscarinic receptors, but its interaction with ligand-gated ion channels remains unexplored. We have studied if Pm affects nicotinic acetylcholine receptors (nAChRs), since they play broad functional roles, both in the nervous system and non-neuronal tissues. Muscle-type nAChRs were incorporated to Xenopus oocytes and the action of Pm on the membrane currents elicited by ACh (IAChs) was assessed. Functional studies were combined with virtual docking and molecular dynamics assays. Co-application of ACh and Pm reversibly blocked IACh, with an IC50 in the low micromolar range. Pm inhibited nAChR by: (i) open-channel blockade, evidenced by the voltage-dependent inhibition of IAch, (ii) enhancement of nAChR desensitization, revealed by both an accelerated IACh decay and a decelerated IACh deactivation, and (iii) resting-nAChR blockade, deduced from the IACh inhibition elicited by Pm when applied before ACh superfusion. In good concordance, virtual docking and molecular dynamics assays demonstrated that Pm binds to different sites at the nAChR, mostly at the transmembrane domain. Thus, Pm from Fritillaria bulbs, considered therapeutic herbs, targets nAChRs with high affinity, which might account for its anti-inflammatory actions. 相似文献