Correlation measurements using clipped laser speckle

Clipped laser speckle is used to measure the correlation of time-varying laser speckle. As with standard intensity correlation, clipped speckle is correlated to determine the magnitude of the correlation coefficient. The simple nature of clipped speckle permits high-speed measurements of correlation and velocity. A closed form approximation to the clipped correlation function valid for arbitrary clipping thresholds is presented. The approximation is used to make correlation measurements on speckle from a rotating diffuser using a 2-D random access detector array.     

Internal stability of dynamic quantised control for stochastic linear plants

Existing analyses of ‘zooming’ quantisation schemes for bit-rate-limited control systems rely on the encoder and controller being initialised with identical internal states. Due to the quantiser discontinuity and the plant instability, it was not clear if closed-loop stability was possible if the encoder and controller commenced from different initial conditions. In this article, we consider partially observed, unstable linear time-invariant plants, with unbounded and possibly non-Gaussian noise, and propose a modified zooming-like scheme with finite-dimensional internal encoder and controller states that may not initially be identical. Using a stochastic pseudo-norm, we prove that this scheme yields mean-square stability in all closed-loop state variables, not just the plant state, under a sufficient condition involving this initial error, the plant dynamics and the channel data rate. With diminishing initial error, this condition approaches a known universal lower bound on data rates and becomes tight. Furthermore, we show that the scheme automatically corrects itself, in the sense that the errors between the internal states of the encoder and controller tend to zero stochastically with time. This suggests that the policy will maintain stability in the presence of channel errors, for sufficiently low bit error rates. We support these conclusions with simulations.     

Mucoadhesive Dosage form of Lidocaine Hydrochloride: I. Mucoadhesive and Physicochemical Characterization

The aim of this study was to characterize a buccal mucoadhesive film using lidocaine and its hydrochloride salt (LDHCL) as a model drug. Buccal films were developed using carbopol 971P as a mucoadhesive polymer, and glycerol as a plasticizer. Scanning Electron Microscope, Differential Scanning Calorimetry, X-ray powder diffraction, and Fourier Transform Infra Red techniques were used to characterize the mucoadhesive films. Bioadhesive properties were evaluated using the Universal Instron Instrument with chicken pouch as a model tissue.

LDHCL and its base were present in carbopol 971P films in a molecular dispersion state without exerting any effect on the glass transition of these films. The mucoadhesive force between the chicken pouches and the film containing glycerol did not change by time during the tested period (1–20 min), while increased with increasing the amount of glycerol (10–40% w/w of polymer content). Furthermore, a linear increase in the mucoadhesive force was accompanied by the increase in the film thickness, while a linear decrease followed by plateau was obtained when loading the patch with LDHCL at concentration above 1 mg/cm².

Loading carbopol film with lidocaine base, in a concentration up to 6 mg/cm² decreased linearly the mucoadhesive properties, which could be attributed to salt formation between the acidic carboxylic moiety of carbopol and basic lidocaine.     

Regulation of Secondary Metabolism in the Penicillium Genus

Penicillium, one of the most common fungi occurring in a diverse range of habitats, has a worldwide distribution and a large economic impact on human health. Hundreds of the species belonging to this genus cause disastrous decay in food crops and are able to produce a varied range of secondary metabolites, from which we can distinguish harmful mycotoxins. Some Penicillium species are considered to be important producers of patulin and ochratoxin A, two well-known mycotoxins. The production of these mycotoxins and other secondary metabolites is controlled and regulated by different mechanisms. The aim of this review is to highlight the different levels of regulation of secondary metabolites in the Penicillium genus.     

Chiral Ligand?Induced Circular Dichroism in Excitonic Absorption of Colloidal Quantum Dots

A range of unique properties have been extensively studied in colloidal semiconductor nanocrystals (quantum dots, QDs). The possibility to manipulate the properties of these systems by controlling size and composition is attractive for many different applications, as well as for fundamental studies. Recently, the properties of chirality and chiroptical activity induced by surface ligands at QDs were considered. It was shown that chiroptical activity can be induced in the exciton transitions of quantum dots by capping them with chiral molecules. In this work, chiroptical spectroscopy (mainly circular dichroism) is used to study induced effects in CdS, CdSe and ZnSe QD systems. Some fundamental differences are encountered between CdS or CdSe samples and ZnSe samples. The results are analyzed to account for the mechanism of induction of chiroptical activity in the inorganic core by chiral capping molecules. Two electronic mechanisms of interaction are considered and discussed in light of the results. It is also suggested that chiroptical spectroscopy might serve as an efficient tool to characterize electronic (or electron-hole) level spectra of nanocrystal systems by analyzing circular dichroism intensity and lineshape.     

Deep Inside Cucurbiturils: Physical Properties and Volumes of their Inner Cavity Determine the Hydrophobic Driving Force for Host–Guest Complexation

Cucurbit[n]urils (CBn) bind guest molecules through a combination of electrostatic interactions with the carbonyl rims and hydrophobic interactions with the inner cavity. Investigations with solvatochromic probes in CB7 reveal that the polarity of the cavity resembles that of alcohols (e.g., n-octanol), while its polarizability (P=0.12) and apparent refractive index (n_D=1.10±0.12) are extremely low, close to the gas phase. The calculated molecular quadrupole moments of CBs are extremely large (Θ_zz=−120 to −340 Buckingham). A survey of reported binding constants of neutral guests and hydrophobic residues that form 1 : 1 inclusion complexes with CB6, reveals a preferential inclusion of C3–C5 residues in its cavity. The largest guests which show non-negligible binding contain 7 heavy atoms (excluding hydrogen). For CB7, the strongest binding is observed for guests with adamantyl (10 heavy atoms) and ferrocenyl groups (11 heavy atoms), while the largest guests known to be complexed are carborane and the adduct of two pyridine derivatives (12 heavy atoms). The evaluation of different volumes shows that the most meaningful cavity, namely that responsible for binding of hydrophobic residues, is confined by the planes through the oxygen carbonyls. The volume of this inner cavity follows the formula V/ų=68+62(n−5)+12.5(n−5)², affording representative cavity volumes of 68 ų for CB5, 142 ų for CB6, 242 ų for CB7, and 367 ų for CB8. The volume of the 2 bond dipole regions is comparably smaller, amounting, for example, to 2×35 ų for CB6. The analysis of packing coefficients for representative sets of known guests with clearly defined hydrophobic binding motifs reveals average values of 47 % for CB5, 58 % for CB6, 52 % for CB7, and 53 % for CB8, which are well in line with the preferred packing (“55 % solution”, see S. Mecozzi, J. Rebek, Chem. Eur. J. 1998 , 4, 1016–1022) in related supramolecular host–guest assemblies. The driving force for binding of hydrophobic guests and residues by CBs is interpreted in terms of the unimportance of dispersion interactions (owing to the low polarizability of their cavity) and the dominance of classical and nonclassical hydrophobic effects related to the removal of very-high-energy water molecules (2 for CB5, 4 for CB6, 8 for CB7, and 12 for CB8) from the cavity.     

Assessing an Engineering Day Camp for Middle-School Girls

Many engineering outreach activities are conducted for young people on university campuses. Many of these programs have some assessment in place, but few have reported results of multiple evaluation and assessment tools. The Future Engineers’ Summer Camp, an engineering day camp for middle-school girls, is a week-long day camp containing hands-on, minds-on activities spanning a range of engineering disciplines. Evaluation and assessment tools including a retrospective survey, evaluation cards, and focus groups are used to evaluate the camp’s activities and determine effectiveness in increasing girls’ knowledge of and attitudes and aspirations toward engineering. Analysis of retrospective surveys demonstrates that the girls learn about engineering while participating in the camp. Evaluation cards, used to evaluate individual activities, indicate that fun is positively correlated with the overall rating of an activity. Additionally, while the girls in the camp already have positive attitudes and high aspirations related to math and science, the camp reinforces these attributes. Recordings and scribe notes of focus-group discussions support retrospective survey results.     

A scheduling framework for large-scale,parallel, and topology-aware applications

Scheduling of large-scale, distributed topology-aware applications requires that not only the properties of the requested machines be considered, but also the properties of the machines’ interconnections. This requirement severely complicates the scheduling process, as even a matching between a single multi-processor task and available machines in a single time slot becomes an NP-complete problem with no polynomial approximation. In this paper we propose a complete scheduling framework for multi-cluster, heterogeneous environments that provides, in practice, an efficient solution for the scheduling of topology-aware applications. The proposed framework is very flexible as it is composed of pluggable components and can be easily configured to support a variety of scheduling policies. We also describe three novel scheduling and coallocation algorithms that were developed and plugged into the framework. The proposed scheduling framework was integrated into the QosCosGrid ¹ system, where it is used as the main decision-making module.