A rotating chimney for compressing rotating fluidized beds

The concept and use of a rotating chimney for compressing rotating fluidized beds is theoretically and experimentally studied. A rotating chimney is shown to drastically increase the operating flexibility of rotating fluidized beds and to allow a significant improvement of the particle bed uniformity. In particular, the rate of solids losses via the chimney can be reduced and bubbling can be suppressed by compressing the rotating particle bed.     

Improved hardware and software for quick gas chromatography-olfactometry using CHARM and GC-"SNIF" analysis

A multisniffing system has been developed to allow three panelists to simultaneously participate in a GC-olfactometric analysis. This device, associated with a computerized data treatment, allows shortening CHARM and GC-"SNIF' analyses to less than 1 week and less than 1 day, respectively. The program was developed as an extension of an existing commercial chromatography data system, as usual GC processing functions are suited to the treatment of olfactograms (plots of odor response versus GC elution time). Because of the improved algorithm, the consequences of gaps in coincident responses were minimized, and the systematic use of a panel improved the repeatability of CHARM olfactograms. Comparing both methods, GC-SNIF repeatability appears to be higher than that of CHARM, as the former method uses a larger panel, but in a shorter lapse of time.     

Online-Literaturdatenbanken im Bereich der Wirtschaftsinformatik: Bereitstellung wissenschaftlicher Literatur und Analyse von Interaktionen der Wissensteilung

Knowledge sharing is fundamental for innovations in the scientific community. The paper examines how the interaction of knowledge sharing is supported by online services. With respect to business information systems, a survey of online literature databases is given, providing an aggregation of various publication sources, a direct access to publications, and which are available to the public. Furthermore, special analysis services are presented which describe competitive interactions of knowledge sharing via rankings on the one hand, and cooperative interactions of knowledge sharing via co-authorship evaluation on the other.     

A biologically inspired active compliant joint using local positive velocity feedback (LPVF).

Starting from studies which revealed that positive feedback is found in the control system for walking in arthropods, we have constructed a new positive feedback driven joint that can be used for solving compliant motion tasks. We propose two different joint constructions each of which shows passive compliance. Based on these joints we introduce three different local positive velocity feedback (LPVF) controllers and discuss their properties in the context of motion generation in closed kinematic chains. The third circuit named undelayed dLPVF is used for the control of a compliant planar manipulator which turns a crank. Our concept is of highly decentralized nature and follows the idea of embodiment. In our case this means that a process which is controlled by LPVF controllers reveals its nature when the controllers interact with this process.     

Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding

Insulin-like growth factor-1 (IGF-1) is a serum protein whichunexpectedly folds to yield two stable tertiary structures withdifferent disulphide connectivities; native IGF-1 [18–61,6–48,47–52]and IGF-1 swap [18–61,6–47, 48–52]. Here we demonstratein detail the biological properties of recombinant human nativeIGF-1 and IGF-1 swap secreted from Saccharomyces cerevisiae.IGF-1 swap had a ~30 fold loss in affinity for the IGF-1 receptoroverexpressed on BHK cells compared with native IGF-1.The parallelincrease in dose required to induce negative cooperativity togetherwith the parallel loss in mitogenicity in NIH 3T3 cells impliesthat disruption of the IGF-1 receptor binding interaction ratherthan restriction of a post-binding conformational change isresponsible for the reduction in biological activity of IGF-1swap. Interestingly, the affinity of IGF-1 swap for the insulinreceptor was ~200 fold lower than that of native IGF-1 indicatingthat the binding surface complementary to the insulin receptor(or the ability to attain it) is disturbed to a greater extentthan that to the IGF-1 receptor. A 1.0 ns high-temperature moleculardynamics study of the local energy landscape of IGF-1 swap resultedin uncoiling of the first A-region -helix and a rearrangementin the relative orientation of the A- and B-regions. The modelof IGF-1 swap is structurally homologous to the NMR structureof insulin swap and CD spectra consistent with the model arepresented. However, in the model of IGF-1 swap the C-regionhas filled the space where the first A-region -helix has uncoiledand this may be hindering interaction of Val44 with the secondinsulin receptor binding pocket.     

Integrated MRI assessment of regional function and perfusion in canine myocardial infarction

A single integrated examination using regional measurements of perfusion from contrast-enhanced MRI and three-dimensional (3D) strain from tissue-tagged MRI was developed to differentiate infarcted myocardium from adjacent tissue with functional abnormalities. Ten dogs were studied at baseline and 10 days after a 2-hour occlusion of the left anterior descending coronary artery (LAD). Strain was determined using a 3D finite element model. Two-dimensional measurements of hypoenhancing regions were highly correlated with myocardial viability (r = 0.96). Signal intensity versus time curves obtained from contrast-enhanced MRI were used for quantitative perfusion analysis. The remote and adjacent noninfarcted tissue of the dogs with LAD occlusion, as well as the infarcted tissue, exhibited abnormal deformation patterns as compared to normal dogs (positive predictive value (PPV) of strain determination of infarction = 66%). Integration of contrast-enhanced MRI results with 3D strain analysis enabled the delineation of the myocardial infarction (PPV = 100%) from functionally compromised myocardium. This integrated cardiac examination shows promise for noninvasive serial assessment of potentially jeopardized noninfarcted myocardium to study the process of infarct remodeling and expansion.     

Failure to find homology in rat, cat, and monkey for functions of a subcortical structure in avoidance conditioning.

Notes that electrolytic lesions of the centrum-medianum and parafascicularis complex of the thalamus produce, in the rat, large deficits of both acquisition and retention of active-avoidance responses, especially in the 2-way shuttle-box test. The effect of such lesions on 26 male cats and 6 male and 2 female macaques was examined. It was found that lesions in the cat did not produce significant effects, either with acoustical or visual CS, during postoperative relearning. Moreover, rate of extinction was not affected. Negative results were also found in monkeys. These lesions did not modify the threshold of flinch or jump responses to electric shock in either species. (20 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)