Consumption of lily bulb modulates fecal ratios of firmicutes and bacteroidetes phyla in rats fed a high-fat diet

Food Science and Biotechnology - Different ascorbic acid (AA) concentrations of 0.16, 0.20, and 0.24% (w/v) were added to pear juice from the new cultivar Pyrus pyrifolia Nakai cv....     

AMSR/AMSR-E level 2 and 3 algorithm developments and data validation plans of NASDA

In 2002, two spaceborne microwave radiometers were launched to provide new observation data. One sensor is the Advanced Microwave Scanning Radiometer (AMSR), aboard the Advanced Earth Observing Satellite-II (ADEOS-II) of the National Space Development Agency of Japan (NASDA). The other is AMSR-E, aboard Aqua of the National Aeronautics and Space Administration (NASA). AMSR and AMSR-E are almost identical sensors, and have lower frequencies 6 and 10 GHz, in comparison with preceding sensors, such as the Special Sensor Microwave/Imager (SSM/I). In addition to geophysical products currently retrieved from the SSM/I, new products of sea surface temperature and soil moisture have been retrieved from AMSR and AMSR-E by using those lower frequencies. Eleven Principal Investigators were assigned by NASDA to develop algorithms to retrieve geophysical products, and their programs have been installed at the Earth Observation Research Center of NASDA. Geophysical products are currently being validated by several methods, such as using existing in situ data, employing instruments in field observations, and comparing data with other sensor's data.     

Clinical features of small hepatocellular carcinomas as assessed by histologic grades

This paper outlines three important issues in the clinical management of sexually transmitted diseases (STDs) in Papua New Guinea which have, until now, gone unrecognized or been neglected. Suggestions for possible solutions are made. The high prevalence of both chlamydial and trichomonal infections in women cannot be ignored. Both of these infections have been shown to increase the transmission of HIV. The current algorithm for the treatment of vaginal discharges does not include treatment for trichomonal infection in the first instance, yet trichomoniasis has been shown to be the most common STD in community studies both here and elsewhere. Trichomoniasis is usually asymptomatic in men, but still increases the risk of HIV transmission; furthermore, it causes illness in their female partners and thus needs to be treated. The current recommended regimens for the treatment of gonococcal and chlamydial infection are complex due to the number of drugs recommended for gonorrhoea to combat the problem of drug resistance, and the length of therapy for chlamydia. Compliance with such a regimen is likely to be poor, particularly in asymptomatic partners. We need to consider the relative advantages provided by a drug which could be given as a single oral dose for chlamydia, and perhaps for both infections. Azithromycin is one possibility, as it has been shown to be effective for chlamydial infection in numerous studies, and has been found satisfactory for gonorrhoea where local isolates were susceptible. Testing of a small number of isolates from Papua New Guinea has shown that azithromycin may be suitable for use here, but further susceptibility testing needs to be performed. Utilization of services for STDs, particularly by women, is extremely low. This is due to a combination of factors involving limited knowledge of symptomatology and its significance, the asymptomatic nature of many infections, the structure of the services, health worker behaviour, and social attitudes. To address these issues we must make modifications to STD service provision, as well as provide widespread information about the potentially serious consequences of contracting STDs, including both infertility and AIDS. Possible modifications to the services are discussed, and include making routine screening available for women through currently existing services such as family planning and antenatal clinics and considering the possibility of establishing Women's Health Clinics which would provide all primary reproductive health services in an integrated manner.     

Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues

Female rhesus macaques were nasally immunized with p55gag (p55) of SIV and cholera toxin as a mucosal adjuvant. Nasal immunization induced Ag-specific IgA and IgG Abs in mucosal secretions (e.g., cervicovaginal secretions, rectal washes, and saliva) and serum. Furthermore, high numbers of p55-specific IgA and IgG Ab-forming cells were induced in mucosal effector sites, i.e., uterine cervix, intestinal lamina propria, and nasal passage. p55-specific CD4+ T cells in both systemic and mucosal compartments expressed IFN-gamma and IL-2 (Th1-type)- as well as IL-5, IL-6, and IL-10 (Th2-type)-specific mRNA. Moreover, p55-specific CTL activity was demonstrated in lymphocytes from blood, tonsils, and other lymphoid tissues. These results show that nasal immunization with SIV p55 with cholera toxin elicits both Th1- and selective Th2-type cytokine responses associated with the induction of SIV-specific mucosal and serum Abs, and CTL activity. These results offer a promise for the development of protective mucosal immunity to SIV.     

Rate dependence on mechanical properties of unsaturated cohesive soil with stress-induced anisotropy

The strain rate during shearing has been shown in experimental studies to strongly affect the mechanical behaviour of soil. For saturated soil, sufficient knowledge has been obtained to achieve equilibrium conditions for the pore water pressure. Nevertheless, little is known about unsaturated soil. Therefore, this study used a hollow cylindrical torsional shear apparatus to investigate the rate dependence on the deformation and strength properties of unsaturated soil. First, unsaturated specimens were anisotropically consolidated with different directions of major principal stress to assess the rate dependence of the anisotropic behaviour. Then, the shear stress was removed to produce an isotropic stress state. Shearing was applied using the specimens to evaluate the strain rate effects on the mechanical properties of unsaturated cohesive soil. The results indicate that the secant shear modulus increased with the strain rate in both constant suction (CS) and constant water content (CW) conditions. The shear strength did not change with the strain rate under a CW condition, but it decreased with the strain rate under a CS condition.     

Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma

In humans, the coronin family is composed of seven proteins containing WD-repeat domains that regulate actin-based cellular processes. Some members of the coronin family are closely associated with cancer cell migration and invasion. The Cancer Genome Atlas (TCGA) analysis revealed that CORO1C, CORO2A, and CORO7 were significantly upregulated in oral squamous cell carcinoma (OSCC) tissues (p < 0.05). Moreover, the high expression of CORO2A was significantly predictive of the 5-year survival rate of patients with OSCC (p = 0.0203). Overexpression of CORO2A was detected in OSCC clinical specimens by immunostaining. siRNA-mediated knockdown of CORO2A suppressed cancer cell migration and invasion abilities. Furthermore, we investigated the involvement of microRNAs (miRNAs) in the molecular mechanism underlying CORO2A overexpression in OSCC cells. TCGA analysis confirmed that tumor-suppressive miR-125b-5p and miR-140-5p were significantly downregulated in OSCC tissues. Notably, these miRNAs bound directly to the 3′-UTR of CORO2A and controlled CORO2A expression in OSCC cells. In summary, we found that aberrant expression of CORO2A facilitates the malignant transformation of OSCC cells, and that downregulation of tumor-suppressive miRNAs is involved in CORO2A overexpression. Elucidation of the interaction between genes and miRNAs will help reveal the molecular pathogenesis of OSCC.     

A flexible full‐color AMOLED display driven by OTFTs

Abstract— Organic thin‐film‐transistor (OTFT) technologies have been developed to achieve a flexible backplane for driving full‐color organic light‐emitting diodes (OLEDs) with a resolution of 80 ppi. The full‐color pixel structure can be attained by using a combination of top‐emission OLEDs and fine‐patterned OTFTs. The fine‐patterned OTFTs are integrated by utilizing an organic semiconductor (OSC) separator, which is an insulating wall structure made of an organic insulator. Organic insulators are actively used for the OTFT integration, as well as for the separator, in order to enhance the mechanical flexibility of the OTFT backplane. By using these technologies, active‐matrix OLED (AMOLED) displays can be driven by the developed OTFT backplane even when they are mechanically flexed.     

A 65 nm Embedded SRAM With Wafer Level Burn-In Mode, Leak-Bit Redundancy and Cu E-Trim Fuse for Known Good Die

We propose a wafer level burn-in (WLBI) mode, a leak-bit redundancy and a small, highly reliable Cu E-trim fuse repair for an embedded 6T-SRAM to achieve a known good die (KGD) SoC. We fabricated a 16 Mb SRAM with these techniques using 65 nm LSTP technology, and confirmed the efficient operations of these techniques. The WLBI mode enables simultaneous write operation for 6T-SRAM, and has no area penalty and a speed penalty of only 50 ps. The leak-bit redundancy for 6T-SRAM can reduce the infant mortality of the bare die, and improves the standby current distribution. The area penalty is less than 2%. The Cu E-trim fuse can be used beyond the 45 nm advanced process technology. The fuse requires no additional wafer process steps. Using only 1.2 V core transistors will allow CMOS technology scaling to enable fuse circuit size reduction. The trimming transistor is placed under the fuse due to there being no cracking around the trimmed position. We achieve the small fuse circuit size of 6 x 36 mum² using 65 nm technology.     

Photo-induced Surface Property on Transparent Mesoporous Silica Thin Films Containing Single-site Photocatalyst

The transparent Ti-containing or Cr-containing mesoporous silica thin films can be prepared on quartz plate using a spin-coating sol–gel method. The spectroscopic characterization has revealed that these thin films contain isolated and tetrahedrally coordinated titanium oxide moieties and chromium oxide moieties in their frameworks, respectively. These mesoporous silica thin films containing metal oxide moieties have demonstrated a strong hydrophilic surface property even before UV-light irradiation and the appearance of the super-hydrophilic property after UV-light irradiation. Especially, the Cr-containing mesoporous silica (CMS) thin film showed the super-hydrophilic property even under visible light irradiation. In the presence of ethylene gas, the polyethylene was successfully formed on the surface of the CMS thin film under UV-light irradiation. After the formation of polyethylene the surface property of the CMS was converted into hydrophobic while keeping its transparency. The isolated and tetrahedrally coordinated titanium oxide moieties and chromium oxide moieties are responsible for these photo-induced surface reactions.