Bioavailability,rheology, and sensory evaluation of mayonnaise fortified with vitamin D encapsulated in protein-based carriers

Vitamin D lost its functionality during processing and storage, thus, encapsulation with proteins is desirable to preserve bioactivity. The aim of the current study was to develop encapsulated vitamin D fortified mayonnaise (VDFM) using whey protein isolates (WPI) and soy protein isolates (SPI) as encapsulating materials in three different formulations, that is, 10% WPI, 10% SPI, and 5/5% WPI/SPI. Increased shear stress decreased the apparent viscosity along with significant effects on the loss modulus of VDFM. WPI encapsulates showed better results as compared to SPI. WPI based VDFM (M₁) depicted the best results in terms of size and dispersion uniformity of oil droplets. Hue angle and total change differed significantly among treatments. The highest value for overall acceptability was acquired by M₃ (5:5%WPI:SPI-encapsulates) thus proceed for in vivo trials. Serum vitamin D level was significantly higher in the encapsulated VDFM rat group (58.14 ± 6.29 nmol/L) than the control (37.80 ± 4.98 nmol/L). Conclusively, WPI and SPI encapsulates have the potential to improve the stability and bioavailability of vitamin D.     

Parkinson’s Disease Detection Using Biogeography-Based Optimization

In recent years, Parkinson's Disease (PD) as a progressive syndrome of the nervous system has become highly prevalent worldwide. In this study, a novel hybrid technique established by integrating a Multi-layer Perceptron Neural Network (MLP) with the Biogeography-based Optimization (BBO) to classify PD based on a series of biomedical voice measurements. BBO is employed to determine the optimal MLP parameters and boost prediction accuracy. The inputs comprised of 22 biomedical voice measurements. The proposed approach detects two PD statuses: 0-disease status and 1- good control status. The performance of proposed methods compared with PSO, GA, ACO and ES method. The outcomes affirm that the MLP-BBO model exhibits higher precision and suitability for PD detection. The proposed diagnosis system as a type of speech algorithm detects early Parkinson’s symptoms, and consequently, it served as a promising new robust tool with excellent PD diagnosis performance.     

Effect of blanching on microwave freeze drying of stem lettuce cubes in a circular conduit drying chamber

Effects of boiling water and microwave blanching methods on the dielectric properties, electrical conductivity as well as microstructure of stem lettuce cubes (as a model for plant tissue) were studied. The study also focused on how different blanching methods affect microwave freeze-drying (MFD) in a circular conduit drying chamber and conventional freeze drying (FD) of stem lettuce cubes. Results showed that the electrical conductivity of samples blanched by microwave was two times higher than that of boiling water blanched ones and five times higher than that of unblanched samples. Apart from that, dielectric constant (ε′) and loss factor (ε″) of the stem lettuce cubes decreased significantly after freezing. MFD duration of microwave blanched samples was approximately 4.5 h, reduced by 30% compared to boiling water blanched ones. MFD process in a circular conduit yielded products of high quality compared to that in a tray.     

In Vitro Antiamoebic Activity Evaluation and Docking Studies of Metronidazole–Triazole Hybrids

An in‐house database of 520 compounds was docked against Entamoeba histolytica thioredoxin reductase (EhTrR), a promising target for the treatment of amoebiasis. Amongst these, some metronidazole (MTZ)–triazole hybrids were ranked high, with docking scores from ?10.23 to ?7.56. Studies of the binding orientations and conformations show that the head groups of MTZ–triazole hybrids interact with the arginine residues within the binding pocket of EhTrR, making it clear that such is the optimal and most reliable orientation for this class of compounds. The top‐ten MTZ–triazole hybrids were then selected for evaluation of their activity against the HM1:IMSS strain of amoeba. The most active compound, 2‐pyridyl‐(1,2,3‐triazolyl)metronidazole 10 , with an IC₅₀ value of 8.4 nM , was significantly more active than the standard drug MTZ alone. Docking studies revealed that compound 10 may act as an EhTrR inhibitor with activity in the nanomolar range and satisfactory ADME properties; it is a suitable candidate to be carried forward as a potential lead in the discovery of drugs to combat amoebiasis.     

Shape sensitivity analysis of composites in contact using the boundary element method

This paper presents the application of the boundary element method to the shape sensitivity analysis of two-dimensional composite structures in contact. A directly differentiated form of boundary integral equation with respect to geometric design variables is used to calculate shape design sensitivities for anisotropic materials with frictionless contact. The selected design variables are the coordinates of the boundary points either in the contact or non-contact area. Three example problems with anisotropic material properties are presented to validate the applications of this formulation.     

Effect of precipitation on the geological development of badlands in arid regions

The main objective of this paper was to study the effect of precipitation on the geological development of badlands in arid regions. Field observations and laboratory investigations were carried out to characterize the surface soils of the Avonlea badlands in southern Saskatchewan, Canada, which is currently experiencing a rapid development in infrastructure. Three distinct surface sediments were identified: an upper slope of cemented sandstone, a mid-slope on weathered mudrock and a relatively flat basal pediment. Each of these soils reacts differently to rainfall events. Precipitation results in grain size reduction which, together with the consistency limits, explains the water sensitivity of the soils; the fines increased by 16% in the cemented sandstone, 78% in the weathered mudrock and 33% in the basal pediment. Erosion susceptibility was highest in the basal pediment (2% clays) followed by cemented sandstone (cementation by 6% active clays) and then by weathered mudrock (cohesion due to the 40% clay).     

Classroom furniture and anthropometric characteristics of Iranian high school students: Proposed dimensions based on anthropometric data

The study evaluated the potential mismatch between classroom furniture dimensions and anthropometric characteristics of 978 Iranian high school students (498 girls, 480 boys), aged 15-18 years. Nine anthropometric measurements (stature, sitting height, sitting shoulder height, popliteal height, hip breadth, elbow-seat height, buttock-popliteal length, buttock-knee length and thigh clearance) and five dimensions from the existing classroom furniture were measured and then compared together (using match criterion equations) to identify any potential mismatch between them. The results indicated a considerable mismatch between body dimensions of the students and the existing classroom furniture, with seat height (60.9%), seat width (54.7%) and desktop height (51.7%) being the furniture dimensions with a higher level of mismatch. The levels of mismatch varied between the high-school grade levels and between genders, indicating their special requirements and possible problems. The proposed dimensions of the classroom furniture more appropriate for the students were given. This additional information on students' anthropometry can be used by local furniture industries as a starting point for designing more appropriate furniture for school children, or used by schools to aid in furniture selection.