BACKGROUND: Patients with chronic idiopathic constipation can be difficult to manage either medically or surgically. We report our experience of long-term follow-up of 21 patients who had undergone colectomy with ileorectal anastomosis for difficult chronic idiopathic constipation. METHODS: The patients (19 female, 2 male) were aged 26-68 (median = 46) years and had undergone subtotal colectomy 5-12 (median = 8) years before their assessment. They answered a questionnaire about severity of abdominal pain, bloating, urgency, and straining. They also completed the hospital anxiety and depression questionnaire. Fifteen ulcerative colitis patients with panproctocolectomy and 13 colon cancer patients with colonic resection who had a similar follow-up period served as control groups. The following assessments were performed in chronic idiopathic constipation patients with subtotal colectomy: a) oesophageal manometry; b) scintigraphic gastric emptying test; c) review of barium follow-through; d) glucose H2 breath test; e) urodynamic studies; and f) autonomic function tests. RESULTS: Twenty-four per cent of patients with chronic idiopathic constipation had a family history of difficult constipation requiring hospital investigations and treatment. At the time of assessment abdominal pain, bloating, urgency, and straining at defecation were all significantly more frequent in patients with chronic idiopathic constipation with colectomy than in the control groups with colectomy. Seventy-one per cent of chronic idiopathic constipation patients had at least one episode of intestinal obstruction after subtotal colectomy, which is significantly higher (P < 0.01) than in the control groups (ulcerative colitis, 13%; colonic carcinoma, 8%). In patients with chronic idiopathic constipation, among those studied, 68% had some oesophageal motor dysfunction: 19% delayed gastric emptying; 10%, prolonged small-bowel transit on barium follow-through; 54%, abnormal urodynamic variables; and 14%, abnormal autonomic function tests. CONCLUSIONS: This study shows considerable morbidity in a selected cohort of patients with chronic idiopathic constipation who were sufficiently disabled by their symptoms to undergo subtotal colectomy. They had more abdominal and rectal symptoms and more frequent intestinal obstructive episodes than control groups with colonic resection. Evidence of generalized smooth-muscle dysfunction and familial occurrence of constipation suggests a primary chronic intestinal pseudo-obstruction-like disorder in some of these patients. 相似文献
Emotion recognition from facial images is considered as a challenging task due to the varying nature of facial expressions. The prior studies on emotion classification from facial images using deep learning models have focused on emotion recognition from facial images but face the issue of performance degradation due to poor selection of layers in the convolutional neural network model.To address this issue, we propose an efficient deep learning technique using a convolutional neural network model for classifying emotions from facial images and detecting age and gender from the facial expressions efficiently. Experimental results show that the proposed model outperformed baseline works by achieving an accuracy of 95.65% for emotion recognition, 98.5% for age recognition, and 99.14% for gender recognition.
Heterojunction is regarded as a crucial step toward realizing high-performance devices,particularly,forming gradient energy band between heterojunctions benefits self-powered photodetectors.There-fore,in this paper,the synthesis of CsPbI3 nanorods(NRs)and its application as the interfacial layer in high-performance,all-solution-processed self-powered photodetectors are presented.For the bilayer photodetector ITO/ZnO(100 nm)/PbS-TBAI(150 nm)/Au,a responsivity of 3.6 A/W with a specific detec-tivity of 9.8×1012 Jones was obtained under 0.1 mW/cm2 white light illumination at zero bias(i.e.in self-powered mode).Meanwhile,the photocurrent was enhanced to an On/Off current ratio of 10s at zero bias with an open circuit voltage of 0.53 V for trilayer photodetector ITO/ZnO(100 nm)/PbS-TBAI(150 nm)/CsPbI3(250 nm)/Au,in which the CsPbI3 NRs layer works as the interfacial layer.As a result,a specific detectivity of 4.5×1013 Jones with a responsivity of 11.12 A/W was obtained under 0.1 mW/cm2 white light illumination,as well as the rising/decaying time of 0.57 s/0.41 s with excellent stability and reproducibility upto four weeks in air.The enhanced-performance is ascribed to the mis-match bandgap between PbS-TBAI/CsPbI3 interface,which can suppress the carrier recombination and provide efficient transport passages for charge carriers.Thus,it provides a feasible and efficient method for high-performance photodetectors. 相似文献
Objective: The goal of the present work was to make novel co-polymeric micellar carriers for the delivery of docetaxel (DTX).Significance: Co-polymeric micelles can not only solubilize DTX and eliminate the need for toxic surfactants to dissolve it, but also cause passive targeting of the drug to the tumor and reduce its toxic side effects.Methods: Poly(styrene-maleic acid) (SMA) was conjugated to poly (amide-ether-ester-imide)-poly ethylene glycol (PAEEI-PEG). Copolymer synthesis was proven by Fourier transform infrared (FTIR) and 1H-nuclear magnetic resonance (1H-NMR). The SMA-PAEEI-PEG micelles loaded with DTX were prepared and their critical micelle concentration (CMC), zeta potential, particle size, entrapment efficiency, and their release efficiency were studied. MCF-7 and MDA-MB231 breast cancer cells were used to evaluate the cellular uptake and cytotoxicity of the micelles. The antitumor activity of the DTX-loaded nanomicelles was measured in Balb/c mice.Results: The FTIR and HNMR spectroscopy confirmed successful conjugation of SMA and PAEEI-PEG. The drug loading efficiency was in the range of 34.01–72.75% and drug release lasted for 120?h. The CMC value of the micelles was affected by the SMA/PAEEI-PEG ratio and was in the range of 29.85–14.28?µg/ml. The DTX-loaded micelles showed five times more cytotoxicity than the free drug. The DTX loaded micelles were more effective in tumor growth suppression in vivo and the animals showed an enhanced rate of survival.Conclusion: The results show that the SMA-PAEEI-PEG micelles of DTX could potentially provide a suitable parenteral formulation with more stability, higher cytotoxicity, and improved antitumor activity. 相似文献
In this paper, a scheme for decentralized robust control for control affine nonlinear interconnected systems using linear matrix inequalities (LMIs) is presented. Based on the Lyapunov theory, sufficient conditions for closed-loop stability of a nonlinear system, reference input tracking, and disturbance attenuation over its operating-range are obtained. Then, achieving these sufficient conditions are formulated as local LMI optimization problems. By solving the appropriately defined local problems, provided the obtained sufficient conditions are satisfied, the closed-loop stability, input tracking, and disturbance attenuation over the operating-range of the system are guaranteed. The designed controller is linear whose implementation is straightforward. An example is given to illustrate the proposed methodology. 相似文献
We report humidity sensing characteristics of CdTiO3 nanofibers prepared by electrospinning. The nanofibers were porous having an average diameter and length of ~50–200 nm and ~100 μm, respectively. The nanofiber humidity sensor was fabricated by defining aluminum electrodes using photolithography on top of the nanofibers deposited on glass substrate. The performance of the CdTiO3 nanofiber humidity sensor was evaluated by AC electrical characterization from 40% to 90% relative humidity at 25 °C. The frequency of the AC signal was varied from 10?1 to 106 Hz. Fast response time and recovery time of 4 s and 6 s were observed, respectively. The sensor was highly sensitive and exhibited a reversible response with small hysteresis of less than 7%. Long term stability of the sensor was confirmed during 30 day test. The excellent sensing characteristics prove that the CdTiO3 nanofibers are potential candidate for use in high performance humidity sensors. 相似文献
Most of the existing results on the decentralized stabilization of large-scale systems consider systems in the input-output-decentralized form, i.e., systems whose input and output matrices are block diagonal. The controller synthesis for such systems is less involved than that for input-output-centralized ones. In this paper, a transformation is proposed for the input-output decentralization of the generic large-scale system. Using the transformed system, a sufficient condition for failure-tolerant performance stabilization of the original large-scale system in a desirable performance region under decentralized linear output feedback is established. The problem is then reformulated as a constrained nonlinear optimization problem. The proposed methodology results in the optimal reconciliation of failure-tolerant performance stabilization of the overall system, and reliability and low actuator gains of the isolated subsystems. The effectiveness of the proposed approach is demonstrated by an example. 相似文献