Using non-preemptive regions and path modification to improve schedulability of real-time traffic over priority-based NoCs

Network-on-Chip (NoC) is a preferred communication medium for massively parallel platforms. Fixed-priority based scheduling using virtual-channels is one of the promising solutions to support real-time traffic in on-chip networks. Most of the existing works regarding priority-based NoCs use a flit-level preemptive scheduling. Under such a mechanism, preemptions can only happen between the transmissions of successive flits but not during the transmission of a single flit. In this paper, we present a modified framework where the non-preemptive region of each NoC packet increases from a single flit. Using the proposed approach, the response times of certain traffic flows can be reduced, which can thus improve the schedulability of the whole network. As a result, the utilization of NoCs can be improved by admitting more real-time traffic. Schedulability tests regarding the proposed framework are presented along with the proof of the correctness. Additionally, we also propose a path modification approach on top of the non-preemptive region based method to further improve schedulability. A number of experiments have been performed to evaluate the proposed solutions, where we can observe significant improvement on schedulability compared to the original flit-level preemptive NoCs.     

Designing end-to-end resource reservations in predictable distributed embedded systems

Contemporary distributed embedded systems in many domains have become highly complex due to ever-increasing demand on advanced computer controlled functionality. The resource reservation techniques can be effective in lowering the software complexity, ensuring predictability and allowing flexibility during the development and execution of these systems. This paper proposes a novel end-to-end resource reservation model for distributed embedded systems. In order to support the development of predictable systems using the proposed model, the paper provides a method to design resource reservations and an end-to-end timing analysis. The reservation design can be subjected to different optimization criteria with respect to runtime footprint, overhead or performance. The paper also presents and evaluates a case study to show the usability of the proposed model, reservation design method and end-to-end timing analysis.     

Polymer-clay nanocomposite hydrogels for molecular irrigation application

Novel nanocomposite hydrogel pipes on the basis of polyvinyl alcohol and montmorillonite (MMT) clay were prepared via a cyclic freezing–thawing technique and designed for subsurface irrigation in the agricultural sector with extraordinarily reduced water consumption. The results showed that the prepared nanocomposite hydrogel pipes had an exfoliated morphology with improved mechanical and thermal properties. It was shown that the gel contents of nanocomposite hydrogel pipes were increased by increasing the loading level of MMT and, in contrast, the swelling and drying abilities decreased. The water permeation and irrigating performances of the prepared pipes were investigated at the laboratory scale by taking into account the effects of the MMT loading levels in nanocomposite hydrogels and the thickness of pipes. The results indicated a significant decrease in water consumption in nanocomposite hydrogel pipes compared to the pure hydrogel pipe. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48631.     

Front Cover: Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity (ChemBioChem 19/2023)

Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer. FAK functions as a non-receptor tyrosine kinase and scaffolding protein, coordinating several downstream signaling effectors and cellular processes. While drug discovery efforts have largely focused on targeting FAK kinase activity, FAK inhibitors have failed to show efficacy as single agents in clinical trials. Here, using structure-guided design, we report the development of a selective FAK inhibitor (BSJ-04-175) and degrader (BSJ-04-146) to evaluate the consequences and advantages of abolishing all FAK activity in cancer models. BSJ-04-146 achieves rapid and potent FAK degradation with high proteome-wide specificity in cancer cells and induces durable degradation in mice. Compared to kinase inhibition, targeted degradation of FAK exhibits pronounced improved activity on downstream signaling and cancer cell viability and migration. Together, BSJ-04-175 and BSJ-04-146 are valuable chemical tools to dissect the specific consequences of targeting FAK through small-molecule inhibition or degradation.     

Modeling the initiation of dynamic recrystallization using a dynamic recovery model

Dynamic recrystallization flow curve was studied in AISI 410 martensitic stainless steel by performing hot compression tests in a temperature range of 900-1150 °C and at strain rates of 0.001-1 s⁻¹. The Estrin and Mecking's equation for dynamic recovery was used to model the work hardening region of the flow curves. The critical strain and stress for the initiation of dynamic recrystallization were determined using the method developed by Poliak and Jonas. The critical dislocation density for starting dynamic recrystallization was estimated using the Estrin and Mecking's dynamic recovery model. A modified Arrhenius-type equation was used to relate the critical dislocation density to strain rate and temperature. The proposed model was also verified by the model proposed by Roberts and Ahlblom and developed to describe the variation of dislocation density and fractional softening due to dynamic recrystallization up to the peak of flow curve.     

Stress and the Role of the Gut–Brain Axis in the Pathogenesis of Schizophrenia: A Literature Review

Schizophrenia is a severe neuropsychiatric disorder, and its etiology remains largely unknown. Environmental factors have been reported to play roles in the pathogenesis of schizophrenia, and one of the major environmental factors identified for this disorder is psychosocial stress. Several studies have suggested that stressful life events, as well as the chronic social stress associated with city life, may lead to the development of schizophrenia. The other factor is the gut–brain axis. The composition of the gut microbiome and alterations thereof may affect the brain and may lead to schizophrenia. The main interest of this review article is in overviewing the major recent findings on the effects of stress and the gut–brain axis, as well as their possible bidirectional effects, in the pathogenesis of schizophrenia.     

Blending polypropylene with glycidyl methacrylate‐containing polymer to improve adhesion to elastomers

BACKGROUND: Polypropylene (PP) is one of the most widely used polyolefins but gets restricted in surface applications due to its non‐polar nature. Surface properties of films made of PP were modified to improve their adhesion to elastomeric polymers such as thermoplastic polyurethanes (TPU), especially to Pebax^® [poly(ether‐block‐amide)]. RESULTS: Surface modification of PP was brought about by blending it with glycidyl methacrylate (GMA)‐containing polymer to increase its surface energy. Films of modified PP were analyzed to determine the blending efficiency and characterized using contact angle measurements, differential scanning calorimetry, X‐ray photoelectron spectroscopy and scanning electron microscopy. Molecular dynamics simulations were done to determine surface and bulk properties of PP blended with GMA. The computational results correlated very well with the experimental data and revealed that the changes in the surface energy can be linked to the position of the functional group within the sample. T‐Peel tests indicated a 2.4 times increase in adhesion to Pebax^® and only 1.7 times increase in adhesion to TPU compared to unmodified PP. CONCLUSION: The surface energy and enhanced adhesion proved that PP was successfully modified and its surface made more polar. Copyright © 2008 Society of Chemical Industry     

Effect of Polyvinyl Alcohol Modified Silica Particles on the Physical and Gas Separation Properties of the Polyurethane Mixed Matrix Membranes

Silicon - Silicon based particles were prepared using tetraethoxysilane (TEOS) as a silica monomer, and low concentration of polyethylene oxide-polypropylene oxide block copolymer (pluronic) with...     

Plasma treatment of zinc oxide-nanoparticles:polyaniline blend as an active layer for the hybrid bulk heterojunction solar cell applications

In this experimental work, plasma treatment of the active layer in the bulk heterojunction solar cells was studied. The active layers consisting of zinc oxide nanoparticles:polyaniline were spin-coated on indium tin oxide covered glasses then kept in the cold plasma medium for different treatment times. The J-V characteristics were considered under air mass 1.5G standard illumination, and variations of the open-circuit voltages and short circuit currents were studied under different treatment times. The results show that there is an optimum treatment time to improve the properties of the layers. In order to understand the origin of this effect, the Hall coefficient, along with ultraviolet-visible spectra were measured, and for studying the topological impact of plasma on the surface of the layers, atomic force microscopy and Fourier-transform infrared spectroscopy were considered. The measurements confirmed the time dependency of the open-circuit voltages and short circuit currents of the cells on the plasma treatment times. Atomic force microscopy of the layers shows the significant topological effects of the plasma treatments on the surface of the active layers for different treatment times.