Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G‐Quadruplex in the Solid State

Quinoline‐based oligoamide foldamers have been identified as a potent class of ligands for G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or grooves and not G‐tetrads. We report a co‐crystal structure of the antiparallel hairpin dimeric DNA G‐quadruplex (G₄T₄G₄)₂ with tetramer 1 —a helically folded oligo‐quinolinecarboxamide bearing cationic side chains—that is consistent with this hypothesis. Multivalent foldamer–DNA interactions that modify the packing of (G₄T₄G₄)₂ in the solid state are observed.     

Development of Ultra-Low Noise HEMTs for Cryoelectronics at ≤4.2 K

We report on DC and noise characteristics at 4.2 K of High Electron Mobility Transistors (HEMTs) which have been realized at LPN/CNRS. This work is aimed to develop high performance, low-power, low-frequency noise and low-temperature field-effect transistors for the future cryoelectronics. A high quality two-dimensional electron gas (2DEG) based on AlGaAs/GaAs heterostructure has been used to realize appropriately designed HEMTs with different gate configurations. With these transistors, we have obtained, for example, a transconductance of about 100 mS and a voltage gain of 26 with a power dissipation of less than 100 μW at 4.2 K; and a corresponded equivalent input voltage noise of 1.2 nV/Hz^1/2 at 1 kHz and as low as 0.12 nV/Hz^1/2 at 100 kHz.     

A new concept of planar self-reconfigurable modular robot for conveying microparts

Modularity and self-healing are two interesting properties that could help to design more flexible conveyors of micro-objects. In the Smart Blocks project, we propose to design a 2D modular and self-reconfigurable robot composed of centimeter-scale sliding blocks that embed their own actuators and control electronics. This article presents a proof-of-concept of the linkage and of the traveling system as well as an algorithm able to reconfigure a set of blocks from a spatial configuration to another one. Prototype blocks have been realized using electro-permanent magnets which show a good motion speed while saving power consumption during the linkage. Our reconfiguration algorithm is implemented in a simulator software showing in real-time the reconfiguration of the robot.     

(De)stabilization of required and spontaneous postural dynamics with learning.

The present research examined how learning a new ankle-hip coordination influenced the preexisting postural repertoire. Standing participants learned a new ankle-hip coordination mode (relative phase of 90'). Before and after practice, postural patterns were evaluated in two different tasks. In the required task, specific ankle-hip patterns were requested (12 relative phases in multiples of 30'). In the spontaneous task, participants performed a tracking task in which no instructions about ankle-hip coordination were given. Learning induced changes in both required and spontaneous coordination dynamics. When ankle-hip patterns were required, learning led to improvement and homogenization in performance over the entire postural repertoire. When ankle-hip patterns emerged spontaneously, in-phase and antiphase preexisting patterns destabilized and changed toward the learned pattern of 90'. These findings demonstrate that learning a new coordination pattern can induce modifications of patterns that have not been practiced. The results also suggest that the consequences of learning do not generalize across different types of tasks, even when similar coordination modes are involved. We discuss implications of these findings for the generality of learning mechanisms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of secure spread-spectrum modulations applied to still image watermarking

This article shows the results obtained when using secure spread-spectrum watermarking on gray-scale images in the watermark only attack (WOA) framework. Two secure modulations, natural watermarking (NW) and circular watermarking (CW), are compared with classical insecure modulations, spread spectrum (SS) and improved spread spectrum (ISS), from distortion, robustness, and security points of view. Implementations of CW and NW for still images are proposed: they use a wavelet transform and variable strength embedding with bounded distortion. Robustness of these schemes is assured by using JPEG compression and security is quantified by using a source separation technique: independent component analysis (ICA). Finally, tests are conducted on 2,000 natural images. They allow to distinguish between WOA security classes.     

A fuzzy screening model for multiple attribute decision-making

A method for the screening of multiple attribute decision-making problems is presented. The model assists the decision-maker in eliminating inferior alternatives and insignificant attributes prior to a detailed evaluation. A preliminary evaluation of the alternatives provides the information necessary for the reduction of the decision problem. The procedure calculates maximum preference factors on which the decision-maker can base his screening decisions. These factors assess the role of alternatives in the final ranking by estimating their potential to become superior to other alternatives. Since screening tasks are carried out early in decision-making, the information available is generally uncertain. Uncertainty is represented in the model using fuzzy sets. This framework permits the handling of both imprecise and precise (crisp) estimates of impacts and provides a possibil-istic assessment of the risk associated with screening decisions.