Properties of nitrogen-implanted SOI substrates

Properties of nitrogen-implanted silicon-on-insulator (SOI) substrates prepared by implanting different doses of 200 keV nitrogen into 50-70 Ω-cm, p-type silicon substrates at a temperature of 500°C were studied. The distribution of nitrogen was studied using Auger electron spectroscopy. The electrical properties of the active overlayer were studied using Hall-effect measurements and capacitance-voltage depth profile analysis. The insulating integrity of the buried nitride was studied by directly measuring the leakage current from top to bottom through the substrate. Additionally, electric field strength and surface roughness measurements were performed. Nitrogen concentrations in the buried layer increased from below to above the stoichiometric value for Si₃N₄ for increasing dose in the range studied. Nitrogen-related n-type doping is observed in all samples examined, and the magnitude of the doping increased with the increasing implant dose. Insulating buried nitride layers are formed only in samples implanted with very high doses     

Direct Adaptive Dynamic Compensation for Minimum Phase Systems With Unknown Relative Degree

We consider parameter-monotonic direct adaptive control for single-input-single-output minimum-phase linear time-invariant systems with knowledge of the sign of the high-frequency gain (first nonzero Markov parameter) and an upper bound on the magnitude of the high-frequency gain. The first part of the paper is devoted to fixed-gain analysis of single-parameter high-gain-stabilizing controllers. Two novel fixed-gain dynamic compensators are presented for stabilizing minimum-phase systems. One compensator stabilizes systems with arbitrary-but-known relative degree, while the other utilizes a Fibonacci series construction to stabilize systems with unknown-but-bounded relative degree. Next, we provide a general treatment of parameter-monotonic adaptive control, including a result that guarantees state convergence to zero. This result is then combined with the high-gain-stabilizing controllers to yield parameter-monotonic direct adaptive dynamic compensation for minimum-phase systems with either arbitrary-but-known or unknown-but-bounded relative degree     

Semilinear Duhem model for rate-independent and rate-dependent hysteresis

The classical Duhem model provides a finite-dimensional differential model of hysteresis. In this paper, we consider rate-independent and rate-dependent semilinear Duhem models with provable properties. The vector field is given by the product of a function of the input rate and linear dynamics. If the input rate function is positively homogeneous, then the resulting input-output map of the model is rate independent, yielding persistent nontrivial input-output closed curve (that is, hysteresis) at arbitrarily low input frequency. If the input rate function is not positively homogeneous, the input-output map is rate dependent and can be approximated by a rate-independent model for low frequency inputs. Sufficient conditions for convergence to a limiting input-output map are developed for rate-independent and rate-dependent models. Finally, the reversal behavior and orientation of the rate-independent model are discussed.     

SuperDense Quantum Teleportation

Recent advances in experimental technique make SuperDense Teleportation (SDT) possible only now, ten years after my first proposal at an ISI Torino summer conference on Quantum Computing. The effect uses remote state preparation to send more state-specifying parameters per bit than ordinary quantum teleportation (QT) can transmit. The SDT uses a maximally entangled state to teleport the relative phases of an n-dimensional state with equal amplitudes on every standard basis vector. For n greater than or equal to 3, the SDT sends more of these state-specifying parameters than QT. In the limit of large n the ratio is 2 to 1, hence the nomenclature by analogy with Super Dense Coding. Alice’s measurements and Bob’s transformations are far simpler than their corresponding operations in QT. The roles of Charles who chooses the state and Diana who deploys it are different than in QT. My discussion includes a brief review of the progress and possibilities of realization for several different experimental approaches around the world. This paper is the write-up of my remarks at the Festschrift conference for Anton Zeilinger, for many years a close collaborator in the Hampshire College NSF grant continuing our work with Mike Horne and Danny Greenberger started under Cliff Shull at MIT in the late 20th century.     

An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition

A family with 1 case of retinitis pigmentosa (III-1) and 2 cases of Oguchi's disease (III-2, 3) was examined in terms of electrophysiology as well as molecular biology. The proband (III-3), a 42-year-old female, and 2 older brothers (III-1, 2, aged 52 and 45 years) and 2 unaffected members in the same family participated in this study. Corrected visual acuities of the individuals with Oguchi's disease (III-2, 3) were 1.2. On funduscopy, blood vessels stood out in relief against a metallic-appearing background and a Mizuo-Nakamura phenomenon was evident. Full-field electroretinograms (ERGs) recorded from the proband were indicative of rod dystrophy, but results of other electrophysiological examinations (multifocal ERG, pattern ERG and visual-evoked cortical potential recordings) were within normal limits. Patient III-1 had corrected visual acuities of RE 20 cm/m.m. and LE 30 cm/n.d., severe chorioretinal atrophy in both fundi, and full-field ERG revealed rod-cone dystrophy. Mutation of the arrestin gene (1147de1A) was detected in all 3 patients. Visual function in each patient coincides with that of retinitis pigmentosa or Oguchi's disease, respectively.     

Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats

Our previous study indicated that 5-hydroxytryptamine (5-HT) immunoreactive fiber densities were decreased in specific areas of the brain in alcohol-preferring rats (P) when compared with alcohol-nonpreferring rats (NP). The results of our current study show that there are quantitative and qualitative differences in 5-HT innervation in other selected regions of the forebrains of P rats. The 5-HT fiber density in the brains of young adult P and NP rats was measured by immunocytochemistry and quantitative image analysis. A routine error of two-dimensional quantitation of nerve fiber was addressed and an adjustment was made. The amount of 5-HT fibers was significantly lower in CA4 and fasciola cinereum of the dorsal hippocampus, caudate-putamen, and hypothalamus of the P as compared with NP rats (unpaired Student's t tests). In examining the fiber types, we found that, in the frontal cortical and hippocampal regions, where normally fine 5-HT fibers with small varicosities and thick 5-HT fibers with large varicosities coexist, fewer fine 5-HT fibers were seen in P rats as compared with NP rats. The fine fibers are known to be vulnerable to abusive drugs. These observations indicate that (a) there are quantitative differences in 5-HT innervation or that the 5-HT in some 5-HT fibers is reduced to a level undetectable by immunocytochemistry, and (b) the fine 5-HT fibers are specifically reduced to a greater degree in the selected brain regions of P rats when compared with that of NP rats. The involvement of the 5-HT system in the alcohol abuse is discussed.     

Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4, 3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles)

The synthesis and antitumor evaluation of 2, 5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-APs) are described. The key intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positions 6 and 9 with groups of different nucleofugacity for SNAr displacements. The initial displacement of fluoride by a substituted hydrazine leads to the pyrazole analogues. Substitution of the remaining leaving group by an amine or BOC-protected amines leads to the 9-aza-APs 12. These analogues were converted into their maleate or hydrochloride salts 13. In two cases, namely, 13x and 13z, sidearm buildup was also employed in the synthetic pathway. In vitro evaluation of 9-aza-APs against the human colon tumor cell line LoVo uncovered for most of the compounds a cytotoxic potency lower than that of DuP-941 or mitoxantrone and comparable to that of doxorubicin. Only analogues 13c, 13n, and 13ff were as cytotoxic as DuP-941. Interestingly, while DuP-941 was highly cross-resistant in the LoVo cell line resistant to doxorubicin (LoVo/Dx), the 9-aza-APs carrying a distal lipophilic tertiary amine moiety in both chains were capable of overcoming the MDR resistance induced in this cell line. The 9-aza-APs show outstanding in vivo antitumor activity against both systemic P388 murine leukemia and MX-1 human mammary carcinoma transplanted in nude mice. At their optimal dosages, congeners 13a-c, 13f, 13n, 13q, 13x, and 13dd were highly effective against P388 leukemia with T/C% of 200-381, while the T/C% value of DuP-941 was 147. In the MX-1 tumor model, 24 compounds elicited percentages of tumor weight inhibitions (TWI) ranging from 50% to 99%. Congeners 13d, 13k, 13l, 13x, 13z, and 13ee emerged as the most effective ones, with TWI% 96, simliar to that of DuP-941 (TWI% = 95). On the basis of their efficacy profile in additional experimental tumors and lack of cardiotoxicity in preclinical models, two congeners have surfaced as potential clinical candidates.