Treating mineral metabolism disorders in patients undergoing long hemodialysis: A search for an optimal strategy

In hemodialysis (HD) patients, mineral metabolism (MM) disorders have been associated with an increased mortality rate. We report the evolution of MM parameters in a stable HD population undergoing long hemodialysis by performing an annual cross-sectional analysis for every year from 1994 to 2008. The therapeutic strategy has changed: the dialysate calcium concentration has decreased from a mean of 1.7 ± 0.1 to 1.5 ± 0.07 mmol/L and has been adapted to parathyroid hormone serum levels (from 1 to 1.75 mmol/L). The use of calcium-based and aluminum-based phosphate binders has decreased and they have been replaced by sevelamer; alfacalcidol has partly been replaced by native vitamin D. The percentage of patients with a parathyroid hormone serum level between 150 and 300 pg/mL has increased from 9% to 67% (P<0.001); the percentage of patients with phosphataemia between 1.15 and 1.78 mmol/L has increased from 39% to 84% (P<0.001). The percentage of those with albumin-corrected calcemia between 2.1 and 2.37 mmol/L has increased from 29% to 61% (P<0.001), and that of patients with a calcium-phosphorous product (Ca × P) level >4.4 mmol/L decreased from 8.8% to 2% (P=0.02). Although patients undergo long and intensive HD treatment, MM disorders are common. However, an appropriate strategy, mostly consisting of native vitamin D supplementation, progressive replacement of calcium-based phosphate binders with non–calcium-based ones, and individualization of dialysis session duration and dialysate calcium concentration, would result in a drastic improvement.     

Deadline and energy constrained dynamic resource allocation in a heterogeneous computing environment

Energy-efficient resource allocation within clusters and data centers is important because of the growing cost of energy. We study the problem of energy-constrained dynamic allocation of tasks to a heterogeneous cluster computing environment. Our goal is to complete as many tasks by their individual deadlines and within the system energy constraint as possible given that task execution times are uncertain and the system is oversubscribed at times. We use Dynamic Voltage and Frequency Scaling (DVFS) to balance the energy consumption and execution time of each task. We design and evaluate (via simulation) a set of heuristics and filtering mechanisms for making allocations in our system. We show that the appropriate choice of filtering mechanisms improves performance more than the choice of heuristic (among the heuristics we tested).     

Passivity-based control of saturated induction motors

A passivity-based controller, which takes into account saturation of the magnetic material in the main flux path of the induction motor, is developed to provide close tracking of time-varying speed and flux trajectories in the high magnetic saturation regions. The proposed passivity based controller is experimentally verified. Also, a comparison between the controllers based on the saturated and nonsaturated magnetics is presented to demonstrate the benefit of the controller based on the saturated magnetics     

Memetic Pareto differential evolutionary neural network used to solve an unbalanced liver transplantation problem

Donor–recipient matching constitutes a complex scenario difficult to model. The risk of subjectivity and the likelihood of falling into error must not be underestimated. Computational tools for the decision-making process in liver transplantation can be useful, despite the inherent complexity involved. Therefore, a multi-objective evolutionary algorithm and various techniques to select individuals from the Pareto front are used in this paper to obtain artificial neural network models to aid decision making. Moreover, a combination of two pre-processing methods has been applied to the dataset to offset the existing imbalance. One of them is a resampling method and the other is a outlier deletion method. The best model obtained with these procedures (with AUC = 0.66) give medical experts a probability of graft survival at 3 months after the operation. This probability can help medical experts to achieve the best possible decision without forgetting the principles of fairness, efficiency and equity.     

Accelerated carbonation testing of alkali-activated binders significantly underestimates service life: The role of pore solution chemistry

The carbonation resistance of alkali-activated binders is often tested via accelerated test protocols designed for Portland cements, without questioning whether the tests replicate the mechanisms observed in service. Thus, validation of accelerated methods is required to enable realistic prediction of material performance. Changes in pore solution equilibria cause the formation of sodium bicarbonates during accelerated carbonation, compared with hydrous sodium carbonates in natural carbonation. This shifts the carbonation mechanism to favour more rapid reaction progress, to give a higher apparent degree of acceleration (compared to natural conditions) than in Portland cements. The pore solution pH under accelerated carbonation is significantly lower than at natural CO₂ concentrations, leading to a falsely short predicted service life (time to expected corrosion of embedded steel), as natural CO₂ concentrations appear not to reduce the pH below 10. Thus, accelerated carbonation testing is unduly aggressive towards alkali-activated binders, and test results must be cautiously interpreted.     

Characterization of the iterative application of makespan heuristics on non-makespan machines in a heterogeneous parallel and distributed environment

Heterogeneous computing (HC) is the coordinated use of different types of machines, and networks to process a diverse workload in a manner that will maximize the combined performance and/or cost effectiveness of the system. Heuristics for allocating resources in an HC system are based on some optimization criterion. A common optimization criterion is to minimize the completion time of the machine that finishes last (makespan). In this study, we consider an iterative approach that repeatedly runs a mapping heuristic to minimize the makespan of the considered machines and tasks. For each successive iteration, the makespan machine of the previous iteration and the tasks assigned to it are removed from the set of considered machines and tasks. This study focuses on understanding the different mathematical characteristics of resource allocation heuristics that cause them to behave differently when combined with this iterative approach. This paper has three main contributions. The first contribution is the study of an iterative technique used in conjunction with resource allocation heuristics. The second contribution is the definition and mathematical characterization of “iteration invariant” heuristics. The third contribution is to determine the characteristics of a heuristic that will cause the mapping to change across iterations.     

Plasticized P(VDF-TrFE): A new flexible piezoelectric material with an easier polarization process,promising for biomedical applications

In this work, flexible ferroelectric films of P(VDF-TrFE) softened by a plasticizer are elaborated. Morphology, piezoelectric, mechanical, thermal, and crystalline properties of the films are studied. We show that the elastic constant is reduced up to 30% while increasing the remanent polarization and the piezoelectric coefficient thanks to the lubricant property of the plasticizer, helping the orientation of the crystallites. Plus, the decrease of the coercive field from 46 to 32 V/μm after an annealing at 138°C for a plasticizer content ranging between 20 and 50 wt% is observed and an explanation by based on a polymer/plasticizer demixing is provided. It leads to an easier polarization process with a significant saving in time and applied electric field reducing the breakdown voltage. Both effects could be interesting for an industrial production. Finally, a first sensor is elaborated and characterized electrically with homemade test bench. We show that the softening of the P(VDF-TrFE) offers to the device a larger amplitude range of deformations. The combination of the flexibility with high ferroelectric properties of the plasticized P(VDF-TrFE) make it a very promising material for biomedical sensor applications.     

Does the ataxo-choreic form of DRPLA exist in Europe? Search of mutation in 120 families

Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder characterized by a degeneration of cerebellar and pallidal efferents, more frequent in Japan. Isolated cases are also encountered. Patients present with variable combination of signs including myoclonus, ataxia, epilepsy, choreoathetosis and dementia, with onset from childhood to the seventh decade. Clinically, DRPLA may be undistinguishable from other genetic disorders, in particular Huntington's disease or the spinocerebellar ataxias. The genetic basis of the inherited form of DRPLA is an expansion to more than 49 repeats of an unstable trinucleotide (CAG) in the DRPLA gene on the short arm of chromosome 12. We determined the frequency of this mutation in patients with the DRPLA phenotype. One hundred and seventeen patients with cerebellar ataxia, from 94 families and 23 isolated cases, as well as 3 patients from families with undiagnosed autosomal dominant neurodegenerative disorders were investigated for the presence of the expanded sequence. None of the patients carried this mutation. This finding suggests that DRPLA is rare in the French population. The search for the DRPLA mutation is justified in patients with the DRPLA phenotype, however, since genetic counselling is often requested and neither clinical, nor neuropathological examinations permit a definite diagnosis of the underlying disease.