This paper deals with an application of generalized non-linear stress-strain relationships of an incremental nature for a particulate material in order to investigate the behaviour of a bed subjected to a loading cycle during which lateral strain is prevented. Initially, the limiting conditions in a bed of granular material are discussed, and a brief review presented of relevant work already carried out under the condition of no lateral strain. Both normally consolidated, and over-consolidated, beds are considered. The resulting calculations indicate that the stress history of the bed can have, depending on stress levels, a profound effect on behaviour during subsequent reloading. Both the state of stress and the stress-strain behaviour of the deposit are assessed. Finally, the results are shown to have an important application in a number of engineering problems, particularly where overconsolidated beds of material are under consideration.List of symbols
K0
coefficient of earth pressure at rest.
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Kr
Rankine ratio=(1–sin)/(1+sin)
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K1,K2,f1,f2,g
constants found experimentally
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ph
stress in any horizontal direction whenPx=Pz=Ph
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px.
stress in co-ordinate directions
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Pxi,Pyi,Pzi
stress levels in co-ordinate directions at commencement of unloading/reloadcycle
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r1,r2,r3
stress ratios=px (ultimate)/pxi,py (ultimate)/Pyi,pz (ultimate)/Pzi respectively
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Py,
y, etc
a small increment of the quantity concerned
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x.
strains in co-ordinate directions
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angle of internal friction of soil 相似文献
Meeting of the Midlands Region, held at the Carpet Trades Ltd Canteen, Kidderminster, on 13 February 1969, Mr D. O. Douglas in the chair Simulation of dyeing processes on an analogue computer, using techniques described in Part I of this paper (p. 187), has been employed to establish the minimum flow requirements for practical machines using dyes differing in dyeing behaviour. A limiting rate of flow requires to be achieved to eliminate differences in colour between hanks in practical machines. The failure to meet this condition is responsible for much of the problem of achieving level dyeings. 相似文献
In our study, we addressed the development of an agricultural productivity equation within a landscape context for the North Dakota coal fields in Oliver, Mercer, and Dunn counties. The procedure employed principal component analysis to develop a combined vegetation yield variable from spring wheat (Triticum aestivum L.), barley (Hordeum vulgare L), oat (Avena sativa L.), grass/legume, Eastern red cedar (Juniperus virginiana L.), ponderosa pine (Pinus ponderosa var. scopulorum Engelm.), green ash (Fraxinus pennsylvanica Marsh.), Siberian peashrub (Caragana arborescens Lam.), American plum (Prunus americana Marsh.), and common chokecherry (Prunus virginiana L.). The best equation we developed to predict plant growth in the surface mining portion of the study area contained an R 2 = 0.66 and an overall p-value of 0.0001. The regression coefficients were stable under bootstrap and jackknife evaluation procedures and worked relatively well with a subsampling procedure. The equation correlated (0.7301) with reclaimed soil field trials. 相似文献
We have designed and synthesized eight compounds 2-9 which incorporate various amino acid residues in positions 17, 18, and 21 of the glucagon molecule: 2, [Lys17]glucagon amide; 3, [Lys18]glucagon amide; 4, [Nle17,Lys18,Glu21]glucagon amide; 5, [Orn17,18, Glu21]glucagon amide; 6, [d-Arg17]glucagon; 7, [d-Arg18]glucagon; 8, [d-Phe17]glucagon; and 9, [d-Phe18]glucagon. Compared to glucagon (IC50 = 1.5 nM), analogues 2-9 were found to have binding affinity IC50 values (in nM) of 0.7, 4.1, 1.0, 2.0, 5.0, 25.0, 43.0, and 32.0, respectively. When these compounds were tested for their ability to stimulate adenylate cyclase (AC) activity, they were found to be full or partial agonists having maximum stimulation values of 100, 100, 100, 100, 87, 78, 94, and 100%, respectively. On the basis of the X-ray crystal structure of [Lys17,18,Glu21]glucagon amide reported here, the ability to form a salt bridge between Lys18 and Glu21 is probably key to their increased binding and second messenger activities. Among the eight analogues synthesized here, only analogue 4 preserves the ability to form a salt bridge between Lys18 and Glu21. However, since these modifications are minor they do not seem to change the amphiphilic character of the C-terminus, allowing these analogues to reach 78-100% stimulation in the adenylate cyclase assay. Biological data from analogues 6-9 supports the idea that position 18 of glucagon may influence binding only, while position 17 may influence both receptor recognition and transduction. 相似文献
Avian egg yolk contains three main macromolecular constituents: 1) the yolk granules; insoluble particles consisting largely of lipovitellin and phosvitin. They are synthesized in response to hormones in the liver as a precursor protein, vitellogenin, which is soluble in blood. It passes through the oolemma by receptor-mediated endocytosis and is split up enzymically to give fragments that precipitate as granules in the yolk. 2) The livetins; essentially blood serum proteins. The mechanism for their transfer to yolk is not clear. 3) The yolk low density lipoprotein; the major part of yolk (60% of the dry weight). It is synthesized and assembled in the liver as a modified blood very low density lipoprotein, whose main apoprotein is apo B. As with vitellogenin, it enters yolk by endocytosis. Furthermore it is split enzymically to give most of the yolk-lipoprotein apoproteins (apovitellenins III to VI). New evidence for the relationship between yolk apoproteins and apo B has been derived from a comparison of the N-terminal amino acid sequences of apovitellenin IV and apo B. 相似文献
When areally distributed variables are represented by vectors relative to a single reference point location, resultant vectors (distribution vectors) can be used to measure the geographic distribution of the variables simultaneously taking into account (1) thevalues of the variables, (2) thedirection, relative to the reference location, of the points at which the values are located, and (3) thedistances between the reference point and the data points. The distribution vector method provides measures of weighted mean location (distribution mean location) and dispersion (standard distance) that reflect the value direction, and distance of variables relative to the reference location. The distribution vector method has versatile applicability to problems involving areally distributed variables and can be used with other quantitative methods. An illustrative application of the distribution vector method with a statistical spatial interaction model of airline passenger traffic from St. Louis to 27 selected SMSAs for each year from 1960 through 1965 is included.I wish to thank my colleagues Prem S. Laumas and Eldon Reiling as well as Gerhard Tintner, Laurence Jay Mauer and Stanley Johnson, for their comments and suggestions on an earlier version of this paper. 相似文献
A summary of two studies of different types of well-known dyeing machinery is presented. Logical analysis and experimental studies of fluid flow in wet textile processes give a clear understanding of machine operation. This fundamental information combined with present knowledge of dye-fibre chemistry then allows the operation and control to be simulated in ways not previously possible. 相似文献
The paper reports a wide range of experimental data on air entrainment velocities and apparent dynamic contact angles, were a continuous surface entersThe main dimensional correlation took the form: for variables in the range: However, due to the limited range of fluid densities used (0.785-1.26 * 103kg.m3), a simpler correlation for air entrainment velocity was found for the case of the entrainment of air by a plunging solid surface where 0.2 <(ηs/η9u)>< 3.2m.sec-1 was found to be the corresponding rThe critical capillary number Cac was found to lie in the range 0.2 <Cac< 1.26 which agrees very well with a recent study due to GuThe investigation also showed that anomalous behaviour could occur with charged surfaces or surfaces with significant roughness. Surfactant type was al 相似文献
Mycotoxins are common dietary contaminants in most regions of the world. The frequency of exposure to the various families of mycotoxins is often dependent on geographic location, national wealth and related agricultural and regulatory infrastructure, combined with diversity of diet and degree of food sufficiency. Deoxynivalenol (DON) is a Fusarium mycotoxin that frequently contaminates wheat, corn and barley in temperate regions. A number of acute poisoning incidences have been linked to DON-contaminated foods and chronic exposure to lower levels of DON has been predicted in many regions. DON is a potent animal toxin and exposure in humans may cause gastroenteritis, growth faltering and immune toxicity. An ability to conduct accurate exposure assessment at the individual level is required to fully understand the potential health consequences for humans. To date, such exposure biomarkers have been lacking for many important mycotoxins, including DON. To better assess exposure to DON at the individual level, we have developed a robust urinary assay, incorporating immunoaffinity column (IAC) enrichment and LC–MS detection. Further refinement of this urinary assay, by inclusion of 13C-DON as an internal standard, was then undertaken and tested within the UK. DON was frequently observed in urine and was significantly associated with cereal intake. A dietary intervention study demonstrated that avoiding wheat in the diet markedly reduced urinary levels of DON. This biomarker requires further validation but our initial data suggest it may provide a useful tool in epidemiological investigations of the potential health consequences of this common environmental toxin. 相似文献
Directly modulated semiconductor lasers exhibit a dynamic wavelength shift (chirping) arising from gain-induced variations of the laser refractive index. The effect of laser chirping on the performance of multi-Gb/s lightwave systems operating at a wavelength of 1550 nm is investigated. Models suitable for computer-aided analysis are used to describe the dynamic response of the laser and the propagation of chirped optical pulses through a step-index single-mode optical fibre. A truncated pulse train, Gauss quadrature rule method is used to evaluate the average bit error rate of the receiver. This permits pattern effects in the transmitted optical waveform due to the laser dynamics and nonlinear optical power transmission properties of optical fibers to be included in the system model. The influence that modulation and device parameters have on the receiver sensitivity is assessed 相似文献