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51.
DJ Taatjes M Wadsworth PM Absher BE Sobel DJ Schneider 《Canadian Metallurgical Quarterly》1997,21(6):527-536
Vascular wall fibrinolytic system proteins are believed to play a pivotal role in atherogenesis. Tissue-type plasminogen activator (t-PA) and urokinase plasminogen activator (u-PA) influence persistence of luminal thrombi and proteolysis of extracellular matrix, respectively. The major physiologic inhibitor of t-PA and u-PA is plasminogen activator inhibitor type 1 (PAI-1). All three of these fibrinolytic system proteins have been detected in vascular endothelial cells, smooth muscle cells, and macrophages by light microscopic immunohistochemistry. This study was undertaken to delineate, by immunoelectron microscopy, the loci of PAI-1 in smooth muscle cells from intact morphologically normal and atherosclerotic human arteries as well as in isolated and cultured smooth muscle cells from arteries. In intact vessels, PAI-1 immunoreactivity was associated with contractile filaments in cells in both normal and atherosclerotic tissues. Lipid-laden smooth muscle cells in atherosclerotic vessels were mainly of the synthetic phenotype and displayed lesser amounts of PAI-1 associated with rough endoplasmic reticulum and contractile filaments. Isolated smooth muscle cells exhibited either a contractile or synthetic phenotype. In the cells with a contractile phenotype, PAI-1 was associated with the contractile elements, whereas in the cells with a synthetic phenotype, the PAI-1 was associated predominantly with elements of the endoplasmic reticulum. Because PAI-1 is associated predominantly with contractile filaments in smooth muscle cells, the net amount of immunodetectable PAI-1 appears to be greater in contractile compared with synthetic phenotype cells. 相似文献
52.
Dorn R. Baumgartner A. Goth A. Gutu-Nelle A. Koppenborg J. Rehm W. Schneider R. Schneider S. von Wirth J. Weber D. 《Lightwave Technology, Journal of》1991,9(6):709-714
Mechanically shaped preforms (MSP) have been demonstrated to combine economic non-CVD (chemical vapor deposition) processing and low loss, with a published value of 0.63 dB/km and a size of 30 fkm/preform. Improved processing is proposed which results in a minimum loss of 0.27 dB/km at 1550 nm. Preforms capable of yielding 150 fkm have been produced. Reboiling during preform stretching and fiber pulling is identified as the last remaining problem of the process 相似文献
53.
54.
Ralph Schneider Wolfgang Marquardt 《Chemical engineering science》2002,57(10):1763-1792
Information technology has been becoming increasingly important in all areas of engineering during the last few years. Much of the progress achieved in chemical engineering would not have been possible without the enabling methods and tools provided by information technology. This trend will continue in the future but most likely with a considerably wider scope. While individual software tools and services have been in focus until recently, their integration into engineering work processes is an emerging and challenging area of research and development. This contribution attempts to highlight state of the art and future trends in supporting the activities during the life cycle of a chemical process by means of information technology. Emphasis will be largely on the process and plant design process rather than on procurement, manufacturing, and distribution of materials in the supply chain. 相似文献
55.
The common way to construct Voronoi tessellations is to compare the distances between given reference points using a given
distance function. To generalize this distance-function concept we expand an existing approach which defines distance functions
by their ``unit circles'. Our new approach allows modeling the ``unit circles' by a closed Spline curve. Changing the control
polygon directly affects the tessellation's appearance. Typically generalized Voronoi diagrams are represented by Voronoi
vertices and curves separating the individual tiles. To obtain interactive modeling we extended an existing hardware accelerated
rendering approach computing a bitmap-representation using different colors for individual tiles. With our extension, we are
able to use our Spline distance representations as input for a growing process. This growing process easily takes into account
weighting approaches like multiplicative, additive, and even free functional weighting. 相似文献
56.
57.
58.
Decay of hollow atoms above and below a surface 总被引:1,自引:0,他引:1
59.
Ioanna Roussaki Maria Strimpakou Carsten Pils 《Journal of Network and Systems Management》2007,15(1):57-74
The challenge of saturating all phases of pervasive service provision with context-aware functionality lies in coping with
the complexity of maintaining, retrieving and distributing context information. To efficiently represent and query context
information a sophisticated modelling scheme should exist. To distribute and synchronise context knowledge in various context
repositories across a multitude of administrative domains, streamlined mechanisms are needed. This paper elaborates on an
innovative context management framework that has been designed to cope with free-text and location based context retrieval
and efficient context consistency control. The proposed framework has been incorporated in a multi-functional pervasive services
platform, while most of the mechanisms it employs have been empirically evaluated. 相似文献
60.
A multiparameter wearable physiologic monitoring system for space and terrestrial applications. 总被引:4,自引:0,他引:4
Carsten W Mundt Kevin N Montgomery Usen E Udoh Valerie N Barker Guillaume C Thonier Arnaud M Tellier Robert D Ricks Robert B Darling Yvonne D Cagle Nathalie A Cabrol Stephen J Ruoss Judith L Swain John W Hines Gregory T A Kovacs 《IEEE transactions on information technology in biomedicine》2005,9(3):382-391
A novel, unobtrusive and wearable, multiparameter ambulatory physiologic monitoring system for space and terrestrial applications, termed LifeGuard, is presented. The core element is a wearable monitor, the crew physiologic observation device (CPOD), that provides the capability to continuously record two standard electrocardiogram leads, respiration rate via impedance plethysmography, heart rate, hemoglobin oxygen saturation, ambient or body temperature, three axes of acceleration, and blood pressure. These parameters can be digitally recorded with high fidelity over a 9-h period with precise time stamps and user-defined event markers. Data can be continuously streamed to a base station using a built-in Bluetooth RF link or stored in 32 MB of on-board flash memory and downloaded to a personal computer using a serial port. The device is powered by two AAA batteries. The design, laboratory, and field testing of the wearable monitors are described. 相似文献