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排序方式: 共有143条查询结果,搜索用时 390 毫秒
31.
Veronique Lachaize Brisa Pea Catalin Ciubotaru Dan Cojoc Suet Nee Chen Matthew R. G. Taylor Luisa Mestroni Orfeo Sbaizero 《International journal of molecular sciences》2021,22(17)
Clinical effects induced by arrhythmogenic cardiomyopathy (ACM) originate from a large spectrum of genetic variations, including the missense mutation of the lamin A/C gene (LMNA), LMNA D192G. The aim of our study was to investigate the biophysical and biomechanical impact of the LMNA D192G mutation on neonatal rat ventricular fibroblasts (NRVF). The main findings in mutated NRVFs were: (i) cytoskeleton disorganization (actin and intermediate filaments); (ii) decreased elasticity of NRVFs; (iii) altered cell–cell adhesion properties, that highlighted a strong effect on cellular communication, in particular on tunneling nanotubes (TNTs). In mutant-expressing fibroblasts, these nanotubes were weakened with altered mechanical properties as shown by atomic force microscopy (AFM) and optical tweezers. These outcomes complement prior investigations on LMNA mutant cardiomyocytes and suggest that the LMNA D192G mutation impacts the biomechanical properties of both cardiomyocytes and cardiac fibroblasts. These observations could explain how this mutation influences cardiac biomechanical pathology and the severity of ACM in LMNA-cardiomyopathy. 相似文献
32.
Victor Giurgiutiu Matthieu Gresil Bin Lin Adrian Cuc Yanfeng Shen Catalin Roman 《Acta Mechanica》2012,223(8):1681-1691
The modeling of the interaction between piezoelectric wafer active sensors (PWAS) and structural waves and vibration is addressed. Three main issues are discussed: (a) modeling of pitch-catch ultrasonic waves between a PWAS transmitter and a PWAS receiver by comparison between exact Lamb wave solutions and various finite element method (FEM) results; (b) analytical modeling of the power and energy transduction between PWAS and ultrasonic guided waves highlighting the tuning opportunities between PWAS and the waves; (c) the use of the transfer matrix method to model the electromechanical (E/M) impedance method for direct reading of high-frequency local structural vibration and comparison with FEM results. The paper ends with a summary and conclusions followed by recommendations for further work. 相似文献
33.
Zandiatashbar A Picu CR Koratkar N 《Small (Weinheim an der Bergstrasse, Germany)》2012,8(11):1676-1682
The creep behavior of epoxy-graphene platelet (GPL) nanocomposites with different weight fractions of filler is investigated by macroscopic testing and nanoindentation. No difference is observed at low stress and ambient temperature between neat epoxy and nanocomposites. At elevated stress and temperature the nanocomposite with the optimal weight fraction, 0.1 wt% GPLs, creeps significantly less than the unfilled polymer. This indicates that thermally activated processes controlling the creep rate are in part inhibited by the presence of GPLs. The phenomenon is qualitatively similar at the macroscale and in nanoindentation tests. The results are compared with the creep of epoxy-single-walled (SWNT) and multi-walled carbon nanotube (MWNT) composites and it is observed that creep in both these systems is similar to that in pure epoxy, that is, faster than creep in the epoxy-GPL system considered in this work. 相似文献
34.
The oxidation kinetics of hydrosulphide by iron/cerium oxide‐hydroxide (FeCeOx) and dissolved oxygen (DO2) was studied at 0.1 MPa and 298 K in a batch slurry reactor. The oxidation of hydrosulphide by the FeCeOx/DO2 system proceeded via a combined heterogeneous–homogeneous pathway to yield zerovalent sulphur and thiosulphate. The role of dissolved oxygen was twofold: (i) it reoxidized the iron from Fe(II) to active Fe(III), (ii) it prompted the homogeneous oxidation of hydrosulphide to polysulphides and of polysulphides to thiosulphate. The Fe(III) in situ regeneration by DO2 showed that FeCeOx holds promise for a redox scrubbing process targeting the elimination of H2S from the Kraft mill effluents. 相似文献
35.
Catalin Fotea Morgan Alexander Paul Smith James Callaway 《The Journal of Adhesion》2008,84(4):389-400
We present the use of three silane reagents in the vapour phase to react with the surface of magnesium and compare their performance against uncoated material using an accelerated corrosion test. The influence of atmospheric exposure on the corrosion test was also considered and rationalised based on previous models of the magnesium surface. XPS analysis determined that the silanes coated the surface of the metal; the accelerated gas evolution test showed very good corrosion inhibition properties for triethoxy(1H,1H,2H,2H-perfluoro-1-octyl)silane (FSil) in comparison with 3-aminopropyltriethoxysilane (APTE) and the uncoated material. The surface functionalisation using vapour proves to be an effective solvent free method of engineering oxide surfaces. 相似文献
36.
John Z Wen Sophie Ringuette Golnaz Bohlouli-Zanjani Anming Hu Ngoc Ha Nguyen John Persic Catalin F Petre Y Norman Zhou 《Nanoscale research letters》2013,8(1):184
Thermochemical properties and microstructures of the composite of Al nanoparticles and NiO nanowires were characterized. The nanowires were synthesized using a hydrothermal method and were mixed with these nanoparticles by sonication. Electron microscopic images of these composites showed dispersed NiO nanowires decorated with Al nanoparticles. Thermal analysis suggests the influence of NiO mass ratio was insignificant with regard to the onset temperature of the observed thermite reaction, although energy release values changed dramatically with varying NiO ratios. Reaction products from the fuel-rich composites were found to include elemental Al and Ni, Al2O3, and AlNi. The production of the AlNi phase, confirmed by an ab initio molecular dynamics simulation, was associated with the formation of some metallic liquid spheres from the thermite reaction. 相似文献
37.
Cong Tam Nguyen Nicolas Galanis Guillaume Polidori Stéphane Fohanno Catalin V. Popa Arnaud Le Bechec 《International Journal of Thermal Sciences》2009,48(2):401-411
An experimental investigation was performed to study the heat transfer performance of a 36 nm-Al2O3-particle–water nanofluid in a confined and submerged impinging jet on a flat, horizontal and circular heated surface. The tests were realized for the following ranges of the governing parameters: the nozzle diameter is 3 mm and the distance nozzle-to-heated-surface was set to 2, 5 and 10 mm; the flow Reynolds number varies from 3800 to 88 000, the Prandtl number from 5 to 10, and the particle volume fraction is ranging from 0 to 6%. Experimental data, obtained for both laminar and turbulent flow regimes, have clearly shown that, depending upon the combination of nozzle-to-heated surface distance and particle volume fraction, the use of a nanofluid can provide a heat transfer enhancement in some cases; conversely, for other combinations, an adverse effect on the convective heat transfer coefficient may occur. Within the experimental parameters used, it has been observed that highest surface heat transfer coefficients can be achieved using an intermediate nozzle-to-surface distance of 5 mm and a 2.8% particle volume fraction nanofluid. Nanofluids with high particle volume fractions, say 6% or higher, have been found not appropriate for the heat transfer enhancement purpose under the confined impinging jet configuration. On the other hand, for a very small and a large distance of nozzle-to-heated-surface, it has been observed that the nanofluid use does not provide a perceptible heat transfer enhancement and has, for some particular cases, produced a clear decrease of the convective heat transfer coefficient while compared to that obtained using distilled water. 相似文献
38.
B Lacarelle P Pisano T Gauthier PH Villard F Guder J Catalin A Durand 《Canadian Metallurgical Quarterly》1994,36(1-2):127-130
Abbott Laboratories has developed a new software package (Abbottbase pharmacokinetic system or PKS package) that employs the principles of pharmacokinetics to assist clinical pharmacologists and clinicians in designing dosage regimens. This software, which runs on IBM PC compatibles, allows Bayesian estimation of individual pharmacokinetic parameters. The aim of the present study was to validate this new system in routine clinical practice for amikacin (40 intensive care unit patients) and theophylline (20 patients). By using the program one or more times during the treatment (50 cases for amikacin and 46 cases for theophylline), dosing recommendations were obtained in real time for all patients. The predictive performance (bias and precision) was assessed by comparing predicted drug concentrations with those measured 24-48 h after dosage recommendation. In the case of amikacin, precision and bias were computed separately for peak and trough levels. In all cases, no statistically significant bias was observed. Finally, our results demonstrate the accuracy of the program in predicting drug levels for amikacin and theophylline. Consequently, the PKS package is reliable for the choice of optimal dosage regimen for amikacin and theophylline. 相似文献
39.
M Lagranderie N Winter AM Balazuc B Gicquel M Gheorghiu 《Canadian Metallurgical Quarterly》1998,14(18):1625-1633
Recombinant live Mycobacterium bovis BCG strains (rBCG) expressing different human immunodeficiency virus (HIV) or simian immunodeficiency (SIV) antigens could be good candidates for the development of vaccines against AIDS. To develop effective HIV/SIV vaccines, humoral and cellular immune responses directed against multiple antigens may be essential for the control of the infection. In this study we immunized BALB/c mice via different mucosal routes (oral, aerogenic, nasal, and rectal) with a mixture of three rBCG strains expressing, respectively, the entire SIVmac251 Nef protein, and large fragments of the Env and Gag proteins. All routes of immunization studied induced immunoglobulin A (IgA) antibodies against mycobacterial PPD, SIV Env, and SIV Gag antigens in feces and bronchial lavages as well as specific immunoglobulin G (IgG) in serum. Strong, specific cytotoxic responses of splenocytes against Nef, Env, and Gag was observed whatever the mucosal route of immunization. Therefore, mucosal vaccination with a cocktail of rBCG strains induces local, specific IgA, systemic IgG, and systemic CTLs against the three SIV antigens expressed. Rectal and oral routes seemed the most appropriate route of vaccination to be used to protect against SIV infection. 相似文献
40.
Catalin Croitoru Cosmin Spirchez Daniel Cristea Aurel Lunguleasa Mihai Alin Pop Tibor Bedo Ionut Claudiu Roata Mihai Alexandru Luca 《应用聚合物科学杂志》2018,135(22)
In this article, poly(vinyl chloride) (PVC) sandwich‐structured hybrid composites with amorphous calcium carbonate and wood‐filled cores were obtained by compression molding. It has been determined that wood addition up to a weight ratio of 33% reported to the total filler amount is beneficial in improving both the inter‐filler and filler‐matrix interfacial adhesion, which alongside with the promoting of the amorphous PVC matrix crystallization is responsible for an increase up to 34% in the flexural strength of the composites, compared to unfilled PVC. The hybrid filled composites present up to 35% lower friction coefficients and up to 20% higher Brinell hardness values than the composites filled with calcium carbonate alone. Subsequently, wood addition determines an increase in the oxidation onset temperature for PVC and an increase with up to 20% in the sound and thermal‐insulative properties of the composites, compared to unfilled PVC. The dominating dispersive part of the composites surface energy aids in improving the mass and dimensional stability of the assembly to both water and dilute hydrochloric acid aqueous solutions. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46317. 相似文献