An evaluation of simulation to support contract costing

As global markets have become more customer oriented, rapid response rates are now often among the most important metrics in business. To achieve the required agility many companies have turned to outsourcing in order to focus on developing their core activities. By its nature, outsourcing increases the complexity of supply chain networks as more companies are drawn into global logistics networks. The relationships between each of these companies are controlled by contractual agreements. The fast pace of modern industry means that these contracts are entered into relatively quickly often without a full understanding of the true cost implications. This paper presents research conducted as part of a project with the aim of developing contract costing software for outsourcing enterprises. Findings are presented from a study conducted on a number of companies in the electronics sector. A simulation-based study focused on one of these companies, with some associated experimentation, is also presented.     

Standardization of models and methods used to assess nanoparticles in cardiovascular applications

Nanotechnology has the potential to revolutionize the management and treatment of cardiovascular disease. Controlled drug delivery and nanoparticle-based molecular imaging agents have advanced cardiovascular disease therapy and diagnosis. However, the delivery vehicles (dendrimers, nanocrystals, nanotubes, nanoparticles, nanoshells, etc.), as well as the model systems that are used to mimic human cardiac disease, should be questioned in relation to their suitability. This review focuses on the variations of the biological assays and preclinical models that are currently being used to study the biocompatibility and suitability of nanomaterials in cardiovascular applications. There is a need to standardize appropriate models and methods that will promote the development of novel nanomaterial-based cardiovascular therapies.     

Search-based composition, streaming and playback of video archive content

Locating content in existing video archives is both a time and bandwidth consuming process since users might have to download and manually watch large portions of superfluous videos. In this paper, we present two novel prototypes using an Internet based video composition and streaming system with a keyword-based search interface that collects, converts, analyses, indexes, and ranks video content. At user requests, the system can automatically sequence out portions of single videos or aggregate content from multiple videos to produce a single, personalized video stream on-the-fly.     

Local Built-In Field at the Sub-nanometric Heterointerface Mediates Cascade Electrochemical Conversion of Lithium–sulfur Batteries

Heterogeneous catalytic mediators have been proposed to play a vital role in enhancing the multiorder reaction and nucleation kinetics in multielectron sulfur electrochemistry. However, the predictive design of heterogeneous catalysts is still challenging, owing to the lack of in-depth understanding of interfacial electronic states and electron transfer on cascade reaction in Li–S batteries. Here, a heterogeneous catalytic mediator based on monodispersed titanium carbide sub-nanoclusters embedded in titanium dioxide nanobelts is reported. The tunable catalytic and anchoring effects of the resulting catalyst are achieved by the redistribution of localized electrons caused by the abundant built-in fields in heterointerfaces. Subsequently, the resulting sulfur cathodes deliver an areal capacity of 5.6 mAh cm⁻² and excellent stability at 1 C under sulfur loading of 8.0 mg cm⁻². The catalytic mechanism especially on enhancing the multiorder reaction kinetic of polysulfides is further demonstrated via operando time-resolved Raman spectroscopy during the reduction process in conjunction with theoretical analysis.     

Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity

Electroconductive substrates are emerging as promising functional materials for biomedical applications. Here, the development of biohybrids of collagen and pristine graphene that effectively harness both the biofunctionality of the protein component and the increased stiffness and enhanced electrical conductivity (matching native cardiac tissue) obtainable with pristine graphene is reported. As well as improving substrate physical properties, the addition of pristine graphene also enhances human cardiac fibroblast growth while simultaneously inhibiting bacterial attachment (Staphylococcus aureus). When embryonic‐stem‐cell‐derived cardiomyocytes (ESC‐CMs) are cultured on the substrates, biohybrids containing 32 wt% graphene significantly increase metabolic activity and cross‐striated sarcomeric structures, indicative of the improved substrate suitability. By then applying electrical stimulation to these conductive biohybrid substrates, an enhancement of the alignment and maturation of the ESC‐CMs is achieved. While this in vitro work has clearly shown the potential of these materials to be translated for cardiac applications, it is proposed that these graphene‐based biohybrid platforms have potential for a myriad of other applications—particularly in electrically sensitive tissues, such as neural and neural and musculoskeletal tissues.