Managing Clinical Use of High-Alert Drugs: A Supervised Learning Approach to Pharmacokinetic Data Analysis

Drug-related problems, particularly those that result from sub- or overtherapeutic doses of high-alert medications, have become a growing concern in clinical medicine. In this paper, we use a model-tree-based regression technique (namely, M5) and support vector machine (SVM) for regression to develop learning-based systems for predicting the adequacy of a vancomycin regimen. We empirically evaluate each system's accuracy in predicting patients' peak and trough concentrations in different clinical scenarios characterized by renal functions and regimen types. Our data consist of 1099 clinical cases that were collected from a major tertiary medical center in southern Taiwan. We also examine the use of bagging for enhancing the prediction power of the respective systems and include in our evaluation a salient one-compartment model for performance benchmark purposes. Overall, our evaluation results suggest that both M5 and SVM are significantly more accurate than the benchmark one-compartment model in predicting patients' peak and trough concentrations across all investigated clinical scenarios. M5 appears to benefit considerably from bagging, which has a positive but seemingly smaller effect on SVM. Taken together, our findings indicate supervised learning techniques that are capable of effectively supporting clinicians' use of vancomycin or similar high-alert drugs in their patient care and management.     

Effect of spray nozzle design on liquid-solid contact in fluidized beds

In industrial fluid cokers the feedstock, consisting of heavy bituminous hydrocarbons, is atomized with steam and injected into a hot fluidized bed of coke. Good and uniform contact of the liquid droplets with the solid particles is required to provide heat for the cracking reactions while minimizing mass transfer effects. Experiments in a pilot plant coker have suggested that the initial particle/liquid mixing, in the spray jet, is rather poor. Experiments in a X-ray scanner showed that liquid droplets and entrained particles accumulate just below the tip of the jet plume to form agglomerates.An experimental technique was used to quantitatively determine the quality of mixing with a variety of nozzle configurations including several novel designs. By improving spray stability, redistributing liquid droplets to the solids-rich region of the jet and increasing the surface area of the gas-liquid jet-fluidized bed interface, liquid/solid contact is improved.     

Effects and properties of poly(arylene ether benzonitrile)s of various molecular weights blended with sulfonated poly(ether ether ketone)

Poly(arylene ether benzonitrile) (PAEBN) was synthesized with 2,6‐dichlorobenzonitrile and biphenol. PAEBNs with various molecular weights (MWs), 1,640,000 and 185,000 g/mol, were synthesized by control of the stoichiometry of the monomers and were blended with sulfonated poly(ether ether ketone) (SPEEK). The effects of MW on the water uptake, swelling, methanol permeability, and proton conductivity of the SPEEK/PAEBN blend membranes were investigated. The molecular mobility of the SPEEK/PAEBN blends was also examined in this study. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Effect of current stressing on the reliability of 63Sn37Pb solder joints

The effect of current stressing on the reliability of 63Sn37Pb solder joints with Cu pads was investigated at temperatures of −5 °C and 125 °C up to 600 h. The samples were stressed with 3 A current (6.0 × 10² A/cm² in the solder joint with diameter of 800 μm and 1.7 × 10⁴ A/cm² in the Cu trace with cross section area of 35 × 500 μm). The temperatures of the samples and interfacial reaction within the solder joints were examined. The microstructural change of the solder joints aged at 125 °C without current flow was also evaluated for comparison. It was confirmed that the current flow could cause the temperature of solder joints to rise rapidly and remarkably due to accumulation of massive Joule heat generated by the Cu trace. The solder joints stressed at 125 °C with 3 A current had an extensive growth of Cu₆Sn₅ and Cu₃Sn intermetallic compounds (IMC) at both top and bottom solder-to-pad interfaces. It was a direct result of accelerated aging rather than an electromigration or thermomigration effect in this experiment. The kinetic is believed to be bulk diffusion controlled solid-state reaction, irrespective of the electron flow direction. When stressed at −5 °C with 3 A current, no significant change in microstructure and composition of the solder joints had occurred due to a very low diffusivity of the atoms as most Joule heat was eliminated at low temperature. The IMC evolution of the solder joints aged at 125 °C exhibited a subparabolic growth behavior, which is presumed to be a combined mechanism of grain boundary diffusion and bulk diffusion. This is mainly ascribed to the retardant effect against the diffusion course by the sufficiently thick IMC layer that was initially formed during the reflow soldering.     

WARD: a transmission control protocol-friendly stateless active queue management scheme

In this article, the problem of providing a fair bandwidth allocation to the flows sharing a congested link in a router is investigated. Queue management, bandwidth share and congestion control are very important to both the robustness and fairness of the Internet. The buffer at the outgoing link is a simple FIFO, shared by packets belonging to the flows. A new transmission control protocol (TCP)-friendly router-based active queue management scheme, termed WARD, is proposed to approximate the fair queueing policy. WARD is a simple packet-dropping algorithm with a random mechanism which discriminates against flows that submit more packets per second than is allowed as their fair share. By doing this, it not only protects TCP connections from user datagram protocol flows, but also solves the problem of competing bandwidth among different TCP versions, such as TCP Vegas and TCP Reno. In addition, WARD works quite well for TCP flow isolation even with different round trip times. In other words, WARD improves the unfair bandwidth allocation properties. Furthermore, as it is stateless and easy to implement, WARD controls unresponsive or misbehaving flows with only a minimum overhead.     

水乡城市滨水景观设计初探——以浙江省嘉兴为例

滨水是指与河流、湖泊、江海毗邻的土地或建筑物,它既是陆的边沿,也是水的边缘。作为一种特殊的城市用地,城市滨水区是城市中具有巨大发展潜力的空间领域。     

An efficient resizing technique for the design of tall steel buildings subject to multiple drift constraints

This paper presents an efficient resizing technique for the optimum design of tall steel building frameworks. Specifically, an ‘optimality criteria’ method is applied to minimize the weight of a lateral load-resisting structural system of fixed topology subject to constraints on interstorey drift. By exploiting the fact for building frameworks that member forces are relatively insensitive to changes in member sizes, rigorously-derived optimality criteria are shown to be readily satisfied through an iterative pseudo-discrete optimization procedure that converges in but a few cycles to a least-weight design using commercial-standard steel sections. While not considered herein, it is a simple matter to extend the stiffness-based design procedure to account also for strength requirements. Two building framework examples are presented to illustrate the features of the design optimization method.     

Electronic thermography for the assessment of acute temporomandibular joint pain

Electronic thermography (ET) has the potential to be a nonionizing, noninvasive, low-cost diagnostic alternative for evaluating temporomandibular joint (TMJ) disorders. This study was designed to evaluate the use of ET as a diagnostic aid in the assessment of patients with acute TMJ pain. Computer measurements made using facial thermography were able to distinguish normal patient populations from symptomatic patients with acute TMJ pain. Additional studies are needed before thermographic diagnosis of TMJ disorders will be clinically accepted.