Response to Tabin's (1995) review of Affect in Psychoanalysis.

Spezzano replies to Tabin's 1995 review of his book Affect in Psychoanalysis (see record 1993-97622-000). Spezzano addresses Tabin's impression that he wrote the entire volume only to make the point that affects matter. He points out that the argument in the book is that not only were affects implicitly or explicitly treated as derivatives of something else in each psychoanalytic theory, but that there is a possibility of pulling elements from seemingly incompatible theories together if one assumes affects to be the foundational elements of psychological life rather than derivative. Spezzano makes several other detailed points about his views on Tabin's review of his book. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Overview of a quality assurance/quality control compliance program consistent with FDA regulations and policies for somatic cell and gene therapies: a four year experience

Somatic cell and gene therapy involve the application of biological technologies to an individual patient through the use of living cells which provide a therapeutic benefit (Aliski, 1991). Various forms of cellular and gene therapies are being developed and evaluated in an increasing number of clinical trials for congenital and acquired disorders. The potential and progress of these therapeutic applications have resulted in an increasing effort by the Food and Drug Administration (FDA) to develop the regulatory framework under which these therapeutic approaches would insure safety and efficacy, the primary mandate of the FDA. Over five years ago Cellcor began to define the parameters, specifications, and conditions relevant to a Quality Assurance/Quality Control (QA/QC) program that has evolved to insure safety and maximize the efficacy of applications of the company's ex vivo technology, autolymphocyte therapy. Autolymphocyte therapy is an outpatient form of somatic cell immunotherapy based upon the infusion of T cells that have been activated ex vivo using a combination of previously generated autologous cytokines and an anti-CD3 monoclonal antibody. We have been able to demonstrate the feasibility for the safe, controlled, and consistent preparation and delivery of a cellular therapy by application of relevant GMP regulations. This presentation reviews aspects of this program and chronicles our experience which at present amounts to over 4400 in fusions for over 700 patients. This program provides a high degree of assurance that a cellular therapy program can be carried out in a multisite mode involving hundreds of patients through the strict adherence to cGMP as set forth in existing regulations.(ABSTRACT TRUNCATED AT 250 WORDS)     

Determinants of parafoveal preview benefit in high and low working memory capacity readers: Implications for eye movement control.

The experiment in this article extended studies by A. W. Inhoff and K. Rayner (see record 1988-06513-001) and J. M. Henderson and F. Ferreira (see record 1990-18858-001) to determine how the printed frequency of two adjacent words influenced the benefit of having parafoveal preview of the 2nd word. High- and low-span participants (assessed by M. Daneman and P. A. Carpenter's, [see PA, Vol 66:2775] Reading Span Test) were tested to determine whether working memory capacity influenced parafoveal preview benefit. Parafoveal preview benefit was determined by an interaction of both words' frequencies in first fixation and by the 2nd word's frequency in gaze duration. However, readers were generally fixated closer to the beginning of the 2nd word when the 1st word was low frequency. When the viewing distance confound was minimized, the prior word's frequency did affect parafoveal preview benefit. Parafoveal preview benefit did not vary between reading groups. Group distributions of fixation duration provided no evidence for J. M. Henderson and F. Ferreira's fixation cutoff model. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Continuous casting update

A critical survey of available information on primary and secondary cooling as affecting solidification constants, and their validity in mathematical modeling. A review of the mathematics of reciprocation. Comments on the function and mode of mold lubrication. The important effects of the above parameters and of liquid metal handling procedures on the internal and external quality of strand cast billets and slabs.     

Ultrasonic Measurement of Lateral Pharyngeal Wall Displacement

A technique employing diagnostic ultrasound to evaluate lateral pharyngeal wall motion during connected discourse is described. The validity and reliability of the procedure are discussed. Typical displacement patterns are shown for normal speakers and applications to cleft palate and laryngectomized speakers discussed.     

Effects of trait and state anxiety on the performance of elementary school children in traditional and individualized multiage classrooms.

Evaluated anxiety and performance on concrete and abstract criterion-referenced mathematics tests for 267 1st and 2nd graders assigned to either individualized multiage programs (IMP) or traditional learning environments (TRAD). The State-Trait Anxiety Inventory for Children (STAIC) was used to measure anxiety. Lower trait and state anxiety was associated with the IMP program, and anxiety-reducing effects were greater for 2nd graders. High A-Trait 1st graders performed more poorly than low A-Trait 1st graders. Although IMP 1st graders were lower in A-Trait than TRAD children, they did not differ in performance. For 2nd graders, the IMP environment facilitated the performance of high A-Trait children, but resulted in poorer performance for low A-Trait children. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosomatic etiological factors in neoplasms: A response to Kellerman.

J. Kellerman (see record 1979-26395-001) argues that use of psychiatric patients in a study designed to search for psychosomatic etiological factors in neoplasms may have led to the present authors' negative results (see record 1978-03712-001). It is suggested, however, that the use of psychiatric patients increased the heterogeneity of the sample and probably enhanced, not limited, the likelihood of positive findings. It is also suggested that the inclusion of alcoholics in the study may have masked real differences between neoplasm and control Ss. However, new analyses run on subsets of the malignancy and malignancy-control samples from which alcoholics were first deleted failed to support his contention. New analyses run to test for differences between the frequencies of various high-scale MMPI types in neoplasm and control groups also failed to support the view that neoplasm patients are qualitatively different from controls on the inventory. (2 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)