Role of Cerium on Transformation Kinetics and Mechanical Properties of Low Carbon Steels

Metallurgical and Materials Transactions A - The present study has focused on the detailed dilatometric and electron microscopic analysis of the formation of austenite and its decomposition in two...     

Environment Friendly Machining of Ni–Cr–Co Based Super Alloy using Different Sustainable Techniques

In order to eradicate the use of mineral based cutting fluid, the machining of Ni–Cr–Co based Nimonic 90 alloy was conducted using environment friendly sustainable techniques. In this work, uncoated tungsten carbide inserts were employed for the machining under dry (untreated and cryogenically treated), MQL, and cryogenic cutting modes. The influence of all these techniques was examined by considering tool wear, surface finish, chip contact length, chip thickness, and chip morphology. It was found that the cryogenically treated tools outperformed the untreated tools at 40 m/min. At cutting speed of 80 m/min, MQL and direct cooling with liquid nitrogen brought down the flank wear by 50% in comparison to dry machining. Similarly at higher cutting speed, MQL and cryogenic cooling techniques provided the significant improvement in terms of nose wear, crater wear area, and chip thickness value. However, both dry and MQL modes outperformed the cryogenic cooling machining in terms of surface roughness value at all the cutting speeds. Overall cryotreated tools was able to provide satisfactory results at lower speed (40 m/min). Whereas both MQL and cryogenic cooling methods provided the significantly improved results at higher cutting speeds (60 and 80 m/min) over dry machining.     

Novel Analog Calibration Technique for Current-Steering DACs’ Dynamic Performance

This paper reports the post-layout dynamic performance of a novel calibration technique for current-steering digital-to-analog converter that was proposed previously. This technique not only improves the linearity, but it does so with low power as well as a very low area. It uses an analog feedback loop consisting of four transistors to calibrate each bit of the DAC, and the same feedback circuit is used for all the bits, thus significantly saving the chip area. Layout of the 10-bit calibrated CS DAC circuit was done in a 180-nm technology; the total area of the DAC and the calibration circuit together was 0.16 \(\hbox {mm}^{2}\). Simulation results show that the spurious free dynamic range is 62 dB for signals of 1 MHz at a sampling frequency of 100 MS/s.     

Sol-gel capillary microextraction

Sol-gel capillary microextraction (sol-gel CME) is introduced as a viable solventless extraction technique for the preconcentration of trace analytes. To our knowledge, this is the first report on the use of sol-gel-coated capillaries in analytical microextraction. Sol-gel-coated capillaries were employed for the extraction and preconcentration of a wide variety of polar and nonpolar analytes. Two different types of sol-gel coatings were used for extraction: sol-gel poly(dimethylsiloxane) (PDMS) and sol-gel poly(ethylene glycol) (PEG). An in-house-assembled gravity-fed sample dispensing unit was used to perform the extraction. The analysis of the extracted analytes was performed by gas chromatography (GC). The extracted analytes were transferred to the GC column via thermal desorption. For this, the capillary with the extracted analytes was connected to the inlet end of the GC column using a two-way press-fit fused-silica connector housed inside the GC injection port. Desorption of the analytes from the extraction capillary was performed by rapid temperature programming (at 100 degrees C/min) of the GC injection port. The desorbed analytes were transported down the system by the helium flow and further focused at the inlet end of the GC column maintained at 30 degrees C. Sol-gel PDMS capillaries were used for the extraction of nonpolar and moderately polar compounds (polycyclic aromatic hydrocarbons, aldehydes, ketones), while sol-gel PEG capillaries were used for the extraction of polar compounds (alcohols, phenols, amines). The technique is characterized by excellent reproducibility. For both polar and nonpolar analytes, the run-to-run and capillary-to-capillary RSD values for GC peak areas remained under 6% and 4%, respectively. The technique also demonstrated excellent extraction sensitivity. Parts per quadrillion level detection limits were achieved by coupling sol-gel CME with GC-FID. The use of thicker sol-gel coatings and longer capillary segments of larger diameter (or capillaries with sol-gel monolithic beds) should lead to further enhancement of the extraction sensitivity.     

Cellulose acetate microspheres as floating depot systems to increase gastric retention of antidiabetic drug: formulation, characterization and in vitro-in vivo evaluation

Gastric emptying is a complex process that is highly variable and makes the in vivo performance of drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug delivery systems for more than 12 hours utilizing floating or hydrodynamically controlled drug delivery systems. The objective of this investigation was to develop a floating, depot-forming drug delivery system for an antidiabetic drug based on microparticulate technology to maintain constant plasma drug concentrations over a prolonged period of time for effective control of blood sugar levels. Formulations were optimized using cellulose acetate as the polymer and evaluated in vitro for physicochemical characteristics and drug release in phosphate buffered saline (pH 7.4), and evaluated in vivo in healthy male albino mice. The shape and the surface morphology of the prepared microspheres were characterized by optical microscopy and scanning electron microscopy. In vitro drug release studies were performed and drug release kinetics were calculated using the linear regression method. Effects of stirring rate during preparation and polymer concentration on the size of microspheres and drug release were observed. The prepared microspheres exhibited prolonged drug release (more than 10 hours) and remained buoyant for over 10 hours. Spherical and smooth-surfaced microspheres with encapsulation efficiency ranging from 73% to 98% were obtained. The release rate decreased and the mean particle size increased at higher polymer concentrations. Stirring speed affected the morphology of the microspheres. This investigation revealed that upon administration, the biocompatible depot-forming polymeric microspheres controlled the drug release and plasma sugar levels more efficiently than plain orally given drug. These formulations, with their reduced frequency of administration and better control over drug disposition, may provide an economic benefit to the user compared with products currently available for diabetes control.