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131.
Lorena Perrone Dr. Emmanuelle Mothes Maeva Vignes Anaïs Mockel Cindy Figueroa Marie‐Christine Miquel Dr. Marie‐Lise Maddelein Dr. Peter Faller Prof. Dr. 《Chembiochem : a European journal of chemical biology》2010,11(1):110-118
Amyloid‐β peptides (Aβ) and the protein human serum albumin (HSA) interact in vivo. They are both localised in the blood plasma and in the cerebrospinal fluid. Among other functions, HSA is involved in the transport of the essential metal copper. Complexes between Aβ and copper ions have been proposed to be an aberrant interaction implicated in the development of Alzheimer's disease, where Cu is involved in Aβ aggregation and production of reactive oxygen species (ROS). In the present work, we studied copper‐exchange reaction between Aβ and HSA or the tetrapeptide DAHK (N‐terminal Cu‐binding domain of HSA) and the consequence of this exchange on Aβ‐induced ROS production and cell toxicity. The following results were obtained: 1) HSA and DAHK removed CuII from Aβ rapidly and stoichiometrically, 2) HSA and DAHK were able to decrease Cu‐induced aggregation of Aβ, 3) HSA and DAHK suppressed the catalytic HO. production in vitro and ROS production in neuroblastoma cells generated by Cu–Aβ and ascorbate, 4) HSA and DAHK were able to rescue these cells from the toxicity of Cu–Aβ with ascorbate, 5) DAHK was more potent in ROS suppression and restoration of neuroblastoma cell viability than HSA, in correlation with an easier reduction of CuII–HSA than Cu–DAHK by ascorbate, in vitro. Our data suggest that HSA is able to decrease aberrant CuII–Aβ interaction. The repercussion of the competition between HSA and Aβ to bind Cu in the blood and brain and its relation to Alzheimer's disease are discussed. 相似文献
132.
The effects of precursor and calcination temperature on the nano morphology of ruthenium dioxide on titanium, prepared from thermal decomposition of aqueous salt solutions were investigated. Transmission electron microscopy, X-ray diffraction, gas porosimetry and cyclic voltammetry showed that lower calcination temperature yielded smaller crystallites. The crystallites were between 6 and 22 nm in diameter. When using ruthenium nitrosyl nitrate the firing temperature had a large impact on the grain size, but for chloride there was only a minor effect in the temperature range 350-550 °C. 相似文献
133.
Chiara Uboldi Daniele Bonacchi Giada Lorenzi M Iris Hermanns Christine Pohl Giovanni Baldi Ronald E Unger C James Kirkpatrick 《Particle and fibre toxicology》2009,6(1):18-12
Background
During the last years engineered nanoparticles (NPs) have been extensively used in different technologies and consequently many questions have arisen about the risk and the impact on human health following exposure to nanoparticles. Nevertheless, at present knowledge about the cytotoxicity induced by NPs is still largely incomplete. In this context, we have investigated the cytotoxicity induced by gold nanoparticles (AuNPs), which differed in size and purification grade (presence or absence of sodium citrate residues on the particle surface) in vitro, in the human alveolar type-II (ATII)-like cell lines A549 and NCIH441. 相似文献134.
Elliott Stephen N.; Kratochwill Thomas R.; McKevitt Brian C.; Malecki Christine Kerres 《Canadian Metallurgical Quarterly》2009,24(4):224
The present study examined the effect accommodations have on test results of students with and without disabilities and documented experts’ judgments about the appropriateness of testing accommodations. Test score data were collected from 218 fourth-grade students with and without disabilities on mathematics and science performance tasks and from eight testing experts who evaluated the fairness and validity of a sample of testing accommodations used with these students. Results indicated that, for most students with disabilities and some students without disabilities, packages of testing accommodations had a moderate to large effect on performance task scores. Expert reviewers rated most accommodations for a student with disabilities as being both valid and fair, and they gave accommodations listed on a student’s individualized education program (IEP) significantly higher validity and fairness ratings than accommodations that were not listed on the student’s IEP. Interpretations of these data are provided and implications for practice and future research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
135.
Antoine Debuigne Marie HurtgenChristophe Detrembleur Christine JérômeChristopher Barner-Kowollik Thomas Junkers 《Progress in Polymer Science》2012,37(7):1004-1030
The current review focuses on the relevance and practical benefit of interpolymer radical coupling methods. The latter are developing rapidly and constitute a perfectly complementary macromolecular engineering toolbox to the controlled radical polymerization techniques (CRP). Indeed, all structures formed by CRP are likely to be prone to radical coupling reactions, which multiply the available synthetic possibilities. Basically, the coupling systems can be divided in two main categories. The first one, including the atom transfer radical coupling (ATRC), silane radical atom abstraction (SRAA) and cobalt-mediated radical coupling (CMRC), relies on the recombination of macroradicals produced from a dormant species. The second one, including atom transfer nitroxide radical coupling (ATNRC), single electron transfer nitroxide radical coupling (SETNRC), enhanced spin capturing polymerization (ESCP) and nitrone/nitroso mediated radical coupling (NMRC), makes use of a radical scavenger in order to promote the conjugation of the polymer chains. More than a compilation of macromolecular engineering achievements, the present review additionally aims to emphasize the particularities, synthetic potential and present limitations of each system. 相似文献
136.
Pierre-Henri Horrein Christine Hennebert Frédéric Pétrot 《Journal of Signal Processing Systems》2012,69(1):55-65
This article studies the integration of Graphics Processing Units in a Software Defined Radio environment. Two main solutions are considered, based on two levels of granularity for the parallelization. First, a fine grain parallelism solution, which is an extension of the existing solutions but adapted to operations of large computational complexity, is proposed. Second, an original solution based on coarse grain approach allowing better usage of the computing resources and easier parallelism extraction is described. For both solutions, scheduling and communication design as well as implementation are given, along with integration in the environment. Both solutions have been implemented and compared on different operations types and on multi-operations sequences. It is clearly shown that using the second solution can provide performance improvement, while the first one is not adapted to SDR applications. 相似文献
137.
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139.
Diana Brumini Camilla Bø Furlund Irene Comi Tove Gulbrandsen Devold Donata Marletta Gerd E. Vegarud Christine Monceyron Jonassen 《International Dairy Journal》2013,28(2):109-111
Antiviral activity of Ragusano donkeys' milk proteins was investigated for the effect on echovirus type 5, known to infect the gastrointestinal tract of humans. Three protein fractions were tested; casein (CN), whey protein (WP) and a low molecular whey protein fraction (LWP; <30,000 Da). The antiviral activity of WP and LWP was tested on echovirus type 5 at three concentrations (1, 5 and 10 mg mL?1); CN was assessed only at the lower concentration. All donkey milk protein fractions showed significant inhibition on virus replication at the concentration of 1 mg mL?1, and both WP and LWP fractions showed significant inhibition on the virus replication at all concentrations tested. The strongest antiviral effect was observed for the WP fraction. These findings show that the different whey proteins in donkey milk, probably acting in synergy, exert antiviral activity on echovirus 5 and might contribute to prevent gastrointestinal virus infections in humans. 相似文献
140.
Rainer Dudek Ralf Doering Christine Bombach Bernd Michel 《Microelectronics Reliability》2009,49(8):839-845
Secondary effects on thermal fatigue of solder joints, which frequently have been neglected, were studied by means of the finite element method (FEM). Based on a semi-empirical approach to predict fatigue life by evaluating the cyclic accumulated equivalent creep strain or energy density, effects of organic boards intrinsic properties on solder joint fatigue were investigated. Aspects of more realistic FR-4 board modelling were studied, in particular concerning its in-plane anisotropy and intrinsic warpage behaviour. Intrinsic board warpage was measured on test board level as well as for boards from series production. High intrinsic warpage was in particular found for several test boards. The effects for the worst case scenario observed so far were analysed for both first level and second level interconnects. The change in predicted fatigue life varied between 30% and 500%, the latter most critical effects were found at large QFN components. Another secondary effect studied was to include the frequently neglected interfacial intermetallics into FEM. It turned out that for components with relatively large standoff like LFBGAs the effects were actually negligible, but for the highly miniaturized components like chip resistors CR0201 they are the decisive factor. 相似文献