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41.
This article discusses a longitudinal study of change in disruptive behaviors among nursing home residents treated with neuroleptics compared with those not treated with neuroleptics. Observations were made of 201 participants on admission to and after 1 year in eight skilled nursing facilities. Nine disruptive behaviors were measured using the Psychogeriatric Dependency Rating Scale with nursing assistants. Neuroleptic use was documented from medication records. Odds ratios are reported for the association of behavior at baseline and use of neuroleptics on nine problem behaviors. For those who received neuroleptics during the year, there was greater change in both developing and resolving disruptive behaviors than for those not receiving neuroleptics. For both groups, restless or pacing behavior and belligerent behavior manifested by refusing instructions changed the most, both in developing and in apparently resolving. Our results show that change in disruptive behaviors occurs among nursing home residents regardless of neuroleptic use, but it occurs more frequently among those who receive neuroleptic medication. Knowledge of which disruptive behaviors are most likely to resolve or develop is important in training nursing home staff to cope with the behaviors as well as in planning interventions that may modify such behaviors. 相似文献
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"A reevaluation of cross-sectional versus longitudinal models of residential mobility...casts doubt on the study by Davies and Pickles in 1985 in which it was argued that cross-sectional analysis is inadequate.... With the use of data from the [U.S.] Panel Study of Income Dynamics (PSID), the conclusion of this reevaluation is that longitudinal analysis increases our understanding of the processes and provides a richer understanding of migration and mobility but does not undermine the work that has been produced from cross-sectional analysis." 相似文献
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A. V. Clark C. M. Fortunko M. G. Lozev S. R. Schaps M. C. Renken 《Research in Nondestructive Evaluation》1992,4(3):165-182
An electromagnetic-acoustic transducer (EMAT) system was used in conjunction with a sampled CW signal-processing method to generate, receive, and process longitudinal and shear waves in thin steel sheets. Using the system, swept-frequency measurements were made up to 7.5 MHz. To relate the measurements to sheet steel formability, a dimensionless frequency ratio,K, was computed from the resonant frequencies. From theoretical considerations,K should be related to a measure of steel sheet formability,
. This parameter is traditionally measured by plastically deforming uniaxial tension specimens. Good correlation was found betweenK and
for a set of steel sheet representative of those typically used to produce automobile body parts.Contribution of NIST; not subject to copyright.NIST Guest Researcher; on leave from Technical University of Plovdiv, Bulgaria. 相似文献
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As part of a study of the chemistry of the steam-stimulated recovery of heavy oils, the hydrolysis and subsequent desulphurization of tetrahydrothiophene and thiophene by aqueous solutions of vanadyl and nickel salts was investigated. Vanadyl sulphate and vanadyl chloride were shown to behave very differently, emphasizing that these salts have different molecular species in aqueous solutions. 相似文献
48.
Career visual searchers such as radiologists and airport security screeners strive to conduct accurate visual searches, but despite extensive training, errors still occur. A key difference between searches in radiology and airport security is the structure of the search task: Radiologists typically scan a certain number of medical images (fixed objective), and airport security screeners typically search X-rays for a specified time period (fixed duration). Might these structural differences affect accuracy? We compared performance on a search task administered either under constraints that approximated radiology or airport security. Some displays contained more than one target because the presence of multiple targets is an established source of errors for career searchers, and accuracy for additional targets tends to be especially sensitive to contextual conditions. Results indicate that participants searching within the fixed objective framework produced more multiple-target search errors; thus, adopting a fixed duration framework could improve accuracy for career searchers. 相似文献
49.
Identification and elimination by site-directed mutagenesis of thermolabile aspartyl bonds in Aspergillus awamori glucoamylase 总被引:2,自引:0,他引:2
Chen Hsiu-mei; Ford Clark; Reilly Peter J. 《Protein engineering, design & selection : PEDS》1995,8(6):575-582
Both Dative Aspergillus niger glucoamylase and wild-type Aspergillusawamori glucoamylase expressed in Saccharo-myces cerevisiae,which have identical primary structures, undergo hydrolysisat aspartyl bonds at low pH values and elevated temperatures.In native A.niger enzyme the Aspl26Glyl27 bond was preferentiallycleaved at pH 3.5,while at pH 4.5 cleavage of the Asp257Pro258and Asp293Gly294 bonds was dominant. In wild-type A.awamoriglucoamylase, cleavage of the latter was dominant at both pH3.5 and 4.5. Site-directed mutations Aspl26Glu and Glyl27Alain wild-type enzyme decreased specific activities by 60 and30%, respectively, and increased irreversible thermoinactivationrates 3- to 4-fold at pH 4.5. Replacement of Asp257 with Gluand Asp293 with Glu or Gin decreased specific activities by20%, but greatly reduced cleavage of the Asp257Pro258and Asp293Gly294 bonds. The Asp257Glu mutant was producedvery slowly and was more thermostable than wildtype glucoamylaseat pH 4.5up to 70°C. Replacement of Asp293 with either Gluor Gln significantly raised protein production and slightlyincreased thermostability at pH 3.5 and 4.5, but not at pH5. 相似文献
50.
Ultrafiltration of lake water for potable water production 总被引:1,自引:0,他引:1
Ultrafiltration with coagulation or powdered activated carbon pretreatment is used to treat water from a public water supply. While UF without pretreatment is effective in removing turbidity, pretreatment prior to UF greatly enhances the removal of natural organic matter and trihalomethane precursors. Short-term flux loss can be minimized with backflushing, while long-term irreversible fouling seems to be affected most by the type of membrane polymer. 相似文献