Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

Wiskott-Aldrich syndrome is an X-linked combined immunodeficiency affecting cells of several different hemopoietic lineages. The Wiskott-Aldrich syndrome protein (WASP), which has no homology with any other known protein families, is rich in proline motifs known to contribute to Src homology 3 binding sites. However, its function has not been determined. The Tec family of cytoplasmic tyrosine kinases, which include Btk (the X-linked agammaglobulinemia gene), Itk, and Tec, is thought to be involved in lymphoid cell signaling pathways. In this work, we show binding of WASP to the Src homology 3 domains of Btk, Itk, Tec, Grb2, and phospholipase C-gamma, which suggests a function for WASP in lymphoid cell signaling.     

Prediction of spark paths in a point/two-rod gap in air

Three-dimensional images had been obtained of some 400 positive point/plane sparks in air during previous work and analysis showed that on average each section of the spark was related to the previous one. However there was a large random perturbation (within a probability distribution) which accounted for the tortuous shapes of the spark paths. Simulations based on these findings gave satisfactory agreement in terms of, for example, appearance and fractal dimension. A more fundamental test of this analysis and simulation method has been tried by attempting to simulate a significantly different electrode system: the grounded plane electrode was replaced by two parallel grounded rods. The simulation is then used, firstly to predict the general shape of the spark paths; and secondly to predict how many of the sparks will be between the point electrode and one of the two rods, and how many between it and the other rod. By moving the point electrode in a direction at right angles to the axes of the rods, but at the same height above them, this ratio could be varied. In order to get reasonable consistency it was necessary to run 1000 trials in the simulation for each point electrode position. Different ratios were obtained for different assumptions as to the magnitude of the random element in the section-by-section prediction. A series of experiments with an analogous electrode system gave good agreement in terms of the percentage strikes to a given rod versus the position of the point electrode.     

High resolution solid state C n.m.r. of Canadian peats

Peat samples from three locations in Quebec, Canada, were characterized by ¹³C CP/MAS n.m.r. spectroscopy. The n.m.r. analysis indicates that the peats contain a significant amount of unaltered plant components including cellulose, hemicellulose, lignin, waxes and resins. Integration of specific regions of the spectra can give semi-quantitative estimates of some of these plant components and, in limited cases, information about the degree of decomposition can be obtained from the ¹³C CP/MAS n.m.r. spectrum. Dipolar dephasing experiments and difference spectroscopy were found to be valuable techniques for spectra assignments and enhancement of compositional differences.     

An improved calculation procedure for the radiation pattern of acylindrical leaky-wave antenna of finite size

A method is given for calculating the radiation pattern of a finite-size cylindrical leaky-wave antenna structure consisting of a single source near a planar surface that supports leaky-wave propagation. The method accounts for the finite radius of the planar surface by subtracting the radiation from that part of the leaky wave that lies beyond the physical surface, from the exact radiation pattern corresponding to an infinite planar surface. Experimental results obtained for a leaky-wave structure consisting of multiple dielectric layers above a ground plane confirm the improved accuracy of the method, particularly for the part of the radiation pattern away from the peak     

Discovering Hidden Analogies in an Online Humanities Database

Voluminous databases contain hiddenknowledge, i.e., literatures that are logicallybut not bibliographically linked. Unlinkedliteratures containing academically interestingcommonalities cannot be retrieved via normalsearching methods. Extracting hidden knowledgefrom humanities databases is especiallyproblematic because the literature, written ineverydayrather than technical language, lacksprecision required for efficient retrieval, andbecause humanities scholars seek new analogiesrather than causes. Drawing upon an efficaciousmethod for discovering previously unknown causesof medical syndromes, and searching inHumanities Index, a periodical index included inWILS, the Wilson Database, an illuminating newhumanities analogy was found by constructing asearch statement in which proper names werecoupled with associated concepts.     

Reducing computation time of a wireless resource scheduler by exploiting temporal channel characteristics

Wireless Networks - The long term evolution downlink scheduler must attain a low computation time as it performs scheduling decisions every 1 ms. 5G New Radio introduced mini-slots for the...     

RFID技术与应用中的建模与优化的研究综述

RFID与传感器网络是物联网的基础技术.随着RFID的广泛应用,产生了许多新的建模与优化的问题.分别从RFID技术和应用两个方面对这些新问题的研究情况进行综述.主要问题包括:读卡器网络的布置优化,读卡器负荷平衡,RFID存储的数据分配,高速读入的防碰撞算法,RFID系统的投资回报的分析与决策,RFID带来的业务流程再造问题,供应链中的存储优化问题,个件层(Item-Level)管理带来的新问题,动态信息与快速响应的新问题等.     

Gibbs Ensembles for Nearly Compatible and Incompatible Conditional Models

The Gibbs sampler has been used exclusively for compatible conditionals that converge to a unique invariant joint distribution. However, conditional models are not always compatible. In this paper, a Gibbs sampling-based approach-using the Gibbs ensemble-is proposed for searching for a joint distribution that deviates least from a prescribed set of conditional distributions. The algorithm can be easily scalable, such that it can handle large data sets of high dimensionality. Using simulated data, we show that the proposed approach provides joint distributions that are less discrepant from the incompatible conditionals than those obtained by other methods discussed in the literature. The ensemble approach is also applied to a data set relating to geno-polymorphism and response to chemotherapy for patients with metastatic colorectal cancer.     

Algal growth in primary settled sewage: The effects of five key variables

Photoperiod, at 3240 lx (300 ft candle) light intensity, was found to be the primary limiting factor for algal biomass growth in a bench scale series of experiments using primary settled sewage. At a retention time of seven days, a total effective photoperiod of greater than 6 h a day was required to produce algae at concentration above 500 mg 1⁻¹.Increasing dissolved CO₂ concentration promoted green algae production and resulted in a higher yield than that obtained from the blue green algae which dominated at low levels of dissolved CO₂. Unfortunately, most of the green algae were unicellular, discrete, small particles, and would be expensive to harvest compared with blue-green algae which often grow in colonies possessing a gelatinous sheath or are of filamentous construction.Low temperature favoured algal biomass production because of its effect upon the solubility of CO₂. The addition of bicarbonate also increased algal biomass yield but an excess of ammonium nitrate inhibited algal production.The removal of nitrogen and phosphorus by algae varied with the quantity of algal biomass produced. Under the experimental conditions, nitrogen removal corresponded to about 3 mg per 100 mg of biomass produced and phosphorus removal to about 0.5 mg per 100 mg biomass produced.