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81.
Leemans W Esarey E Geddes C Schroeder C Tóth C 《Philosophical transactions. Series A, Mathematical, physical, and engineering sciences》2006,364(1840):585-600
Guiding of relativistically intense laser beams in preformed plasma channels is discussed for development of GeV-class laser accelerators. Experiments using a channel guided laser wakefield accelerator at Lawrence Berkeley National Laboratory (LBNL) have demonstrated that near mono-energetic 100 MeV-class electron beams can be produced with a 10 TW laser system. Analysis, aided by particle-in-cell simulations, as well as experiments with various plasma lengths and densities, indicate that tailoring the length of the accelerator, together with loading of the accelerating structure with beam, is the key to production of mono-energetic electron beams. Increasing the energy towards a GeV and beyond will require reducing the plasma density and design criteria are discussed for an optimized accelerator module. The current progress and future directions are summarized through comparison with conventional accelerators, highlighting the unique short-term prospects for intense radiation sources based on laser-driven plasma accelerators. 相似文献
82.
Lee Jaehun Bae Kyungmin Ölveczky Peter Csaba Kim Sharon Kang Minseok 《International Journal on Software Tools for Technology Transfer (STTT)》2022,24(6):911-948
International Journal on Software Tools for Technology Transfer - This paper presents the HybridSynchAADL modeling language and formal analysis tool for virtually synchronous cyber-physical systems... 相似文献
83.
Bíró Ferenc Deák András Bársony István Samotev Nikolay Dücső Csaba 《Microsystem Technologies》2022,28(11):2511-2528
Microsystem Technologies - Due to their complex electro-thermal characteristics microhotplates used in environmental gas sensors require careful design to exhibit uniform temperature and low power... 相似文献
84.
Renta Szab Denise Brzsei Zsuzsanna Szab Alexandra Hoffmann Istvn Zupk Dniel Priksz Krisztina Kupai Csaba Varga Anik Psa 《International journal of molecular sciences》2020,21(22)
Endocannabinoids and their receptors are present in the cardiovascular system; however, their actions under different pathological conditions remain controversial. The aim of our study was to examine the effects of anandamide (AEA) on heme oxygenase (HO) and nitric oxide synthase (NOS) systems in an estrogen-depleted rat model. Sham-operated (SO) and surgically induced estrogen-deficient (OVX) female Wistar rats were used. During a two-week period, a group of OVX rats received 0.1 mg/kg estrogen (E2) per os, while AEA-induced alterations were analyzed after two weeks of AEA treatment at the dose of 1.0 mg/kg. At the end of the experiment, cardiac activity and expression of HO and NOS enzymes, content of cannabinoid 1 receptor, as well as concentrations of transient potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP) were measured. Our results show that estrogen withdrawal caused a significant decrease in both NOS and HO systems, and a similar tendency was observed regarding the TRPV1/CGRP pathway. Two weeks of either AEA or E2 treatment restored the adverse changes; however, the combined administration of these two molecules did not result in a further improvement. In light of the potential relationship between AEA and HO/NOS systems, AEA-induced upregulation of HO/NOS enzymes may be a therapeutic strategy in estrogen-deficient conditions. 相似文献
85.
Myleidi Vera Csaba Fodor Yadiris Garcia Eduardo Pereira Katja Loos Bernabé L. Rivas 《应用聚合物科学杂志》2020,137(47):49562
Laccase enzymes of were covalently coimmobilized on poly(glycidyl methacrylate) microspheres. The objective of this work was to create a biocatalyst that works efficiently in a wide range of pH. The coimmobilization was performed using two different strategies to compare the most efficient. The results showed that by correctly selecting the enzymes and concentrations involved in the commobilization, it is possible to obtain a biocatalyst that works efficiently at a wide pH range (2.0–7.0). The maximum activity values reached per gram of support for the obtained biocatalyst were 41.90 U (pH 3.0), 40.89 U (pH 4.0), and 39.54 U (pH 6.0). Moreover, the thermal, storage, and mechanical stabilities were improved compared to the free and single-immobilized laccases. It was concluded that enzymatic coimmobilization is an excellent alternative to obtain a robust biocatalyst that works in a wide pH range, with potential environmental and industrial applications. 相似文献
86.
87.
Co‐immobilized Whole Cells with ω‐Transaminase and Ketoreductase Activities for Continuous‐Flow Cascade Reactions 下载免费PDF全文
László Nagy‐Győr Emese Abaházi Dr. Viktória Bódai Dr. Péter Sátorhelyi Dr. Balázs Erdélyi Dr. Diána Balogh‐Weiser Prof. Dr. Csaba Paizs Dr. Gábor Hornyánszky Prof. Dr. László Poppe 《Chembiochem : a European journal of chemical biology》2018,19(17):1845-1848
An improved sol–gel process involving the use of hollow silica microspheres as a supporting additive was applied for the co‐immobilization of whole cells of Escherichia coli with Chromobacterium violaceum ω‐transaminase activity and Lodderomyces elongisporus with ketoreductase activity. The co‐immobilized cells with two different biocatalytic activities could perform a cascade of reactions to convert racemic 4‐phenylbutan‐2‐amine or heptan‐2‐amine into a nearly equimolar mixture of the corresponding enantiomerically pure R amine and S alcohol even in continuous‐flow mode. The novel co‐immobilized whole‐cell system proved to be an easy‐to‐store and durable biocatalyst. 相似文献
88.
89.
Cover Picture: Phenylalanine Ammonia‐Lyase‐Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles (ChemBioChem 16/2015) 下载免费PDF全文
90.
Benedetta Fois Žiga Skok Prof. Dr. Tihomir Tomašič Prof. Dr. Janez Ilaš Prof. Dr. Nace Zidar Prof. Dr. Anamarija Zega Prof. Dr. Lucija Peterlin Mašič Petra Szili Gábor Draskovits Ákos Nyerges Dr. Csaba Pál Prof. Dr. Danijel Kikelj 《ChemMedChem》2020,15(3):265-269
The emergence of multidrug-resistant bacteria is a global health threat necessitating the discovery of new antibacterials and novel strategies for fighting bacterial infections. We report first-in-class DNA gyrase B (GyrB) inhibitor/ciprofloxacin hybrids that display antibacterial activity against Escherichia coli. Whereas DNA gyrase ATPase inhibition experiments, DNA gyrase supercoiling assays, and in vitro antibacterial assays suggest binding of the hybrids to the E. coli GyrA and GyrB subunits, an interaction with the GyrA fluoroquinolone-binding site seems to be solely responsible for their antibacterial activity. Our results provide a foundation for a new concept of facilitating entry of nonpermeating GyrB inhibitors into bacteria by conjugation with ciprofloxacin, a highly permeable GyrA inhibitor. A hybrid molecule containing GyrA and GyrB inhibitor parts entering the bacterial cell would then elicit a strong antibacterial effect by inhibition of both the GyrA and GyrB subunits of DNA gyrase and potentially slow bacterial resistance development. 相似文献