Is There a Window of Heightened Suicide Risk If Patients Gain Energy in the Context of Continued Depressive Symptoms?

The authors' purpose is to provide some empirical perspective on the important but understudied possibility that when people become more energetic in the context of continued depressive symptoms, suicide risk escalates. The authors studied 109 suicidal young adults; among those who initially reported substantial depression, a subgroup was identified whose energy was increasing in context of continued depressive symptoms. They were compared with others with regard to suicidality 1 month later. Results suggested that those who have incomplete remissions (of any sort) may be more ill to begin with, and this may account for higher suicide risk. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sunitinib release from biodegradable films of poly(l-lactide-co-caprolactone)

The aim of this study was to prepare sunitinib-loaded biodegradable films using poly(l-lactide-co-?-caprolactone) (PLCL) for anti-tumor drug delivery. Sunitinib-loaded PLCL film has a rough surface, while empty film has a smooth surface. PLCL film loaded with 5% (w/w) sunitinib showed an absence of a crystalline peak of sunitinib, while sharp peaks were observed at 10% (w/w) loading, indicating that sunitinib was molecularly distributed in the polymer matrix at 5% (w/w). A drug release study revealed an initial burst during the first 2 h, followed by continuous release until 24 h. Since weight loss of film was <10% for 1 week, drug release mechanism was dominantly dependent on the diffusion-mediated release of drugs to the medium. Sunitinib has a dose-dependent anti-proliferation effect against HuCC-T1 human cholangiocarcinoma cells in vitro. These results indicate that sunitinib-loaded PLCL film is a appropriate candidate as a vehicle for anti-tumor drug delivery.     

Interaction rules underlying group decisions in homing pigeons

Travelling in groups gives animals opportunities to share route information by following cues from each other''s movement. The outcome of group navigation will depend on how individuals respond to each other within a flock, school, swarm or herd. Despite the abundance of modelling studies, only recently have researchers developed techniques to determine the interaction rules among real animals. Here, we use high-resolution GPS (global positioning system) tracking to study these interactions in pairs of pigeons flying home from a familiar site. Momentary changes in velocity indicate alignment with the neighbour''s direction, as well as attraction or avoidance depending on distance. Responses were stronger when the neighbour was in front. From the flocking behaviour, we develop a model to predict features of group navigation. Specifically, we show that the interactions between pigeons stabilize a side-by-side configuration, promoting bidirectional information transfer and reducing the risk of separation. However, if one bird gets in front it will lead directional choices. Our model further predicts, and observations confirm, that a faster bird (as measured from solo flights) will fly slightly in front and thus dominate the choice of homing route. Our results explain how group decisions emerge from individual differences in homing flight behaviour.     

Identifying the natural flow regime and the relationship with riparian vegetation for two contrasting western Australian rivers

The natural flow regime and the relationship between flows and riparian vegetation are described for sites on both the Blackwood River in south‐western Australia and the Ord River in north‐western Australia. Analysis of long‐term flow data showed the historic mean monthly river discharge for the Blackwood River is strongly seasonal and highly predictable with generally low variability each month. The Ord River showed a strong seasonality of flows with about 92% of the (total) yearly flow occurring between December and March. Flow variability was very high (e.g. coefficient of variation >100% for all months) but highly predictable, with this mostly attributed to low but constant dry‐season flows. Water depth, duration of flood events and the number of flood events per year show a significant correlation with aspects of the riparian vegetation within experimental vegetation plots. Results highlight the strong relationship between floristics, life form structure and population dynamics with stream hydrology. On the Blackwood River, species richness and cover of shrubs reduced with increased duration and frequency of flooding, while cover of exotic species and annual herbs increased with increased flooding. Germination of tree seedlings was not influenced by flood regime but size class of tree species increased with flooding frequency. On the Ord River, species richness was not influenced by flooding regime. However, cover of perennial grasses increased with flooding frequency whilst cover of shrubs decreased. There was no relationship between flooding and seedling establishment whilst tree size class decreased with increased flooding. The methods described here can be used to compare the response of different components of the riparian vegetation to different fluvial regimes (e.g. because of impoundment and abstraction). This technique can be expanded for the management of riparian zones and planning rehabilitation programmes. It may also be useful for improving the ecological knowledge base for setting environmental flows in regulated systems. Copyright © 2001 John Wiley & Sons, Ltd.     

A general dynamic simulation model for evaporators and condensers in refrigeration. Part II: simulation and control of an evaporator: Modèle général dynamique pour évaporateurs et condenseurs frigorifiques. Partie II: Simulation et régulation d'un évaporateur

A mathematical model of an evaporator based on one-dimensional partial differential equations representing mass conservation, and tube wall energy has been formulated. These equations are then restructured and linked to a program data base of all major refrigerants and refrigerant mixtures. The result is a simulation model of an evaporator that is general and flexible. The model is tested over a wide range of operating conditions and a simple controller is implemented to demonstrate the effectiveness of the model for controller and systems design.     

Time resolved study of electrode reactions using Fourier transform impedance spectroscopy: mutually correlated adsorption kinetics of Cu and ClO4 on gold

This work demonstrates the time resolved capability of Fourier transform electrochemical impedance spectroscopy (FT-EIS) for in situ kinetic studies of electrode reactions. The model system studied here is a gold electrode, employed as a substrate for dc voltage controlled deposition and stripping of copper in the presence of ClO₄⁻ ions in an aqueous electrolyte. Full Nyquist plots are collected through 1-s intervals during the occurrence of dc voltage controlled surface reactions. Distinctly different signatures of deposition and stripping of Cu are observed in the time resolved EIS data. Mutually coupled EIS features of ClO₄⁻ and Cu²⁺ indicate how the two types of ions affect each other’s adsorption kinetics as functions of the applied dc voltage.     

Multiple risk factors in the development of externalizing behavior problems: group and individual differences

The aim of this study was to test whether individual risk factors as well as the number of risk factors (cumulative risk) predicted children's externalizing behaviors over middle childhood. A sample of 466 European American and 100 African American boys and girls from a broad range of socioeconomic levels was followed from age 5 to 10 years. Twenty risk variables from four domains (child, sociocultural, parenting, and peer-related) were measured using in-home interviews at the beginning of the study, and annual assessments of externalizing behaviors were conducted. Consistent with past research, individual differences in externalizing behavior problems were stable over time and were related to individual risk factors as well as the number of risk factors present. Particular risks accounted for 36% to 45% of the variance, and the number of risks present (cumulative risk status) accounted for 19% to 32% of the variance, in externalizing outcomes. Cumulative risk was related to subsequent externalizing even after initial levels of externalizing had been statistically controlled. All four domains of risk variables made significant unique contributions to this statistical prediction, and there were multiple clusters of risks that led to similar outcomes. There was also evidence that this prediction was moderated by ethnic group status, most of the prediction of externalizing being found for European American children. However, this moderation effect varied depending on the predictor and outcome variables included in the model.