Fluidity and Flow Properties of Fine Powders

ABSTRACT

Fluidization and/or flow properties of many fine powders (d₅₀ < 50 μm), including pharmaceutical powders, toners, powder paints, and ceramic powders, are of critical importance. Particles in this range behave as cohesive powder because of the relatively large inter-particle forces (electrostatic, van der Waals', and liquid bridge forces), compared to the hydrodynamic force exerted on the particles by the fluid flowing around the particles. Flow additives, mechanical agitation, and other forces such as acoustic and electromagnetic, are often applied for good fluidization and uniform dilute phase flow. In this paper, we present a brief discussion and experimental data on fluidization properties, fluidity, and flow behavior of several fine powders as functions of particle size distribution, relative humidity, relative concentration of flow additives, and the frequency and amplitude of mechanical agitation. Electrostatic charging, dependent upon the chemical composition and electrical conductivity of the particles, and its influence upon the flow properties are also presented.     

Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly(dl-lactide-<Emphasis Type="Italic">co</Emphasis>-glycolide) block copolymer

Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib. Transmission electron microscopy of the sorafenib-incorporated DexbLG nanoparticles revealed a spherical shape with a diameter < 300 nm. Sorafenib-incorporated DexbLG nanoparticles at a polymer/drug weight ratio of 40:5 showed a relatively uniform size and morphology. Higher initial drug feeding was associated with increased drug content in nanoparticles and in nanoparticle size. A drug release study revealed a decreased drug release rate with increasing drug content. In an in vitro anti-proliferation assay using human cholangiocarcinoma cells, sorafenib-incorporated DexbLG nanoparticles showed a similar antitumor activity as sorafenib. Sorafenib-incorporated DexbLG nanoparticles are promising candidates as vehicles for antitumor drug targeting.     

Historical carbon footprinting and implications for sustainability planning: a case study of the Pittsburgh region

This study estimates fossil-based CO(2) emissions and energy use from 1900-2000 for Allegheny County, PA. Total energy use and emissions increased from 1900 to 1970, reflecting the significant industrial, economic, and population growth that occurred in Allegheny County. From 1970 to 2000, Allegheny County experienced a 30% decrease in total emissions and energy use from peak values, primarily because of a decline in industrial activity (40% decrease in value added) and the loss of a quarter of its population. Despite these dramatic economic and demographic transitions, per capita emissions remained stable from 1970 to 2000, buoyed by relatively stable or slightly increasing emissions in the commercial and transportation sectors. Allegheny County's history suggests the scale of change needed to achieve local emissions reductions may be significant; given years of major technological, economic, and demographic changes, per capita emissions in 1940 were nearly the same in 2000. Most local governments are planning emissions reductions rates that exceed 1% per year, which deviate significantly from historical trends. Our results suggest additional resources and improved planning paradigms are likely necessary to achieve significant emissions reductions, especially for areas where emissions are still increasing.