A theoretical design basis for minimizing CMOS fixed taper bufferarea

This paper develops a theoretical basis for the minimization of chip area required for fixed taper buffer design. It modifies the well-known procedure for minimizing delay time in such circuits to derive a minimum number of required stages. Rather than minimize delay time, the procedure realizes a specified buffer delay time using a stage-area scale factor that minimizes the total area of the buffer. Since an integer number of tapered stages must be used while the calculations lead to noninteger results, the effects of roundoff errors are included     

Cortical implants for the blind

Arrays of stimulating electrodes can be placed in the brain itself, in the visual cortex, to bring vision to the profoundly blind. However, when designing such devices one needs to take into consideration the fact that the visual pathway maps images onto cortical structures in a complex and unpredictable way     

Finite twist and extension of a cylindrical elastic membrane

Summary We consider a circular cylindrical membrane subjected to longitudinal extension and twist. The associated equilibrium deformation is considered to be axisymmetric and the analysis is based on a direct two-dimensional formulation. Wrinkling of the membrane is taken into account in an approximate way by introducing arelaxed strain energy function derived from the neo-Hookean strain energy for isotropic elastic solids. Analytical formulae for wrinkled parts of the membrane are used to corroborate the results of a numerical treatment of the full boundary value problem.Dedicated to the memory of A. C. Pipkin     

Direct algorithms for data analysis in the location of sources of radiation from measured differences in distance: Model experiment

Results are presented from a model (numerical) experiment performed to check the efficiency of three groups of direct data-analysis algorithms to be used in satellite location of ground or ocean sources of radiation. The methodology behind the experiment is also explained. Translated from Izmeritel'naya Tekhnika, No. 12, pp. 40–44, December, 1996.     

Evaluation of a Conical Mill for Screening of Direct Compression Formulations

Suitability of a Quadro Comil^TM for screening of direct compression tablet masses was evaluated with respect to alteration of particle size distribution and blending efficiency. Air jet sieving was qualijied for determination of a particle size of spraydried lactose and microcrystalline cellulose. Using a full 3¹ × 2³ factorial design not only effects of single processing parameters (output screen size, impeller shape, velocity of the mill, and type of powder), but also their respective combinations were investigated in terms of impact on particle size and flow properties (angle of repose, bulk and tapped densities). Particle sizes before and after passing the Comil were found to be normally distributed. The results indicate that the process does not allow any of the powder characteristics studied beyond normal batch-to batch variability. This refers in particular to the proportion of fines. For evaluation of the deagglomeration effectiveness, a 2³ design was implemented with iron oxide as a model drug. Homogeneity of the blends was determined optically, and after screening twice it was found to be acceptable even with this substance, which has a particularly high agglomeration tendency, high density, and small particle size. The Quadro Comil is therefore regarded as fully suitable for deagglomeration of powders in a gentle and effective manner     

Ascitic fluid analysis in hepatocellular carcinoma

BACKGROUND: Ascites in patients with hepatocellular carcinoma (HCC) is a poorly characterized subgroup of malignancy-related ascites. Not only the underlying liver disease, but also the tumor growth and spread contributes to the ascites formation. The authors differentiated ascites in HCC from other types of ascites. METHODS: The authors analyzed the ascitic fluid of 185 consecutive patients (89 liver cirrhosis, 33 HCC, 31 peritoneal carcinomatosis, 22 liver metastases, 10 spontaneous bacterial peritonitis). RESULTS: Each subgroup showed a typical pattern. Compared with the cirrhotic patients, those with HCC showed a higher frequency of positive cytologic findings (4 of 33 versus 0/89, P < 0.004), elevated fibronectin concentration (10/33 versus 8/89, P < 0.004), and elevated polymorphonuclear cell count (10/33 versus 5/89 P < 0.004). CONCLUSIONS: A significant number of patients with ascites and HCC patients showed signs of peritoneal infiltration with positive cytologic findings and increased concentration of fibronectin. Moreover, neutrocytic ascites without signs of superinfection is relatively common (30%).     

Cyclooxygenase and lipoxygenase arachidonate metabolites synthesized by mouse peritoneal macrophages: in vitro effect of N-phenyllinoleamide from toxic oil samples

N-phenyllinoleamide (NPLA) has been detected as extraneous compound in adulterated cooking oils associated with a unique epidemic disease known as the Toxic Oil Syndrome (TOS). In this communication we report on the action of NPLA on the endogenous cyclooxygenase and lipoxygenase arachidonate metabolism. Results show that mouse peritoneal macrophages (MPM) exposed to 1 mM NPLA for 2 h undergo significant increases of 6-keto prostaglandin F1a, prostaglandin E2, leukotriene B4, 12- and 15-hydroxyeicosatetraenoic acids. MPM prelabelled with 3H-AA showed an enhanced release when exposed to NPLA. Thus, it is concluded that NPLA potentiates AA release from cell membrane phospholipids and the subsequent cyclooxygenase and lipoxygenase oxidative metabolism of this precursor to various eicosanoids. This is in agreement with the implication of peroxidative process mediated by fatty acids anilides in TOS.     

Comparison of two Varieties of Microcrystalline Cellulose as Filler-Binders II. Hydrochlorothiazide Tablets

In tests of direct-compression hydrochlorothiazide tablets prepared with either of two varieties of microcrystalline cellulose (Avicel PH 101 and Avicel PH 102), PH 102 tablets had better mechanical properties (owing to lower compressibility of mixtures and greater Interparticle bonding), while PH 101 tablets released the active principle faster. These differences are related to observed differences In tablet micropore structure.