Determination of the Optimal Fourier Number on the Dynamic Thermal Transmission

This article represents the result of experimental research on transient heat transfer in a multilayered (heterogeneous) wall. Our non-steady thermal transmission simulation is based on a finite-difference calculation method. The value of a Fourier number shows the similarity of thermal variation in conditional layers of an enclosure. Most scientists recommend using no more than a value of 0.5 for the Fourier number when performing calculations on dynamic (transient) heat transfer. The value of the Fourier number is determined in order to acquire reliable calculation results with optimal accuracy. To compare the results of simulation with experimental research, a transient heat transfer calculation spreadsheet was created. Our research has shown that a Fourier number of around 0.5 or even 0.32 is not sufficient (\({\approx }17\,\%\) of oscillation amplitude) for calculations of transient heat transfer in a multilayered wall. The least distorted calculation results were obtained when the multilayered enclosure was divided into conditional layers with almost equal Fourier number values and when the value of the Fourier number was around 1/6, i.e., approximately 0.17. Statistical deviation analysis using the Statistical Analysis System was applied to assess the accuracy of the spreadsheet calculation and was developed on the basis of our established methodology. The mean and median absolute error as well as their confidence intervals has been estimated by the two methods with optimal accuracy (\({F}_{\mathrm{oMDF}}= 0.177\) and \(F_{\mathrm{oEPS}}= 0.1633\) values).     

Defining the e-learner’s security profile: Towards awareness improvement

The paper presents an improved e-learner model that supports monitoring of user behavior related to information security. The model is built upon standardized IMS specification, according to literature research and survey conducted among e-learners. It is positioned as key part of an extended LTSA architecture in which the learner data is used to improve learner security position by continuous delivery of important information and adapting security mechanisms. The implementation is considered in Moodle LMS.     

The influence of bile salts on the distribution of simvastatin in the octanol/buffer system

Abstract

Introduction: Distribution coefficient (D) is useful parameter for evaluating drugs permeability properties across biological membranes, which are of importance for drugs bioavailability. Given that bile acids are intensively studied as drug permeation-modifying and -solubilizing agents, the aim of this study was to estimate the influence of sodium salts of cholic (CA), deoxycholic (DCA) and 12-monoketocholic acids (MKC) on distribution coefficient of simvastatin (SV) (lactone [SVL] and acid form [SVA]) which is a highly lipophilic compound with extremely low water solubility and bioavailability.

Methods: LogD values of SVA and SVL with or without bile salts were measured by liquid–liquid extraction in n-octanol/buffer systems at pH 5 and 7.4. SV concentrations in aqueous phase were determined by HPLC-DAD. Chem3D Ultra program was applied for computation of physico-chemical properties of analyzed compounds and their complexes.

Results: Statistically significant decrease in both SVA and SVL logD was observed for all three studied bile salts at both selected pH. MKC exerted the most pronounced effect in the case of SVA while there were no statistically significant differences between observed bile salts for SVL. The calculated physico-chemical properties of analyzed compounds and their complexes supported experimental results.

Conclusions: Our data indicate that the addition of bile salts into the n-octanol/buffer system decreases the values of SV distribution coefficient at both studied pH values. This may be the result of the formation of hydrophilic complexes increasing the solubility of SV that could consequently impact the pharmacokinetic parameters of SV and the final drug response in patients.     

A subexponential bound for linear programming

We present a simple randomized algorithm which solves linear programs withn constraints andd variables in expected $$\min \{ O(d^2 2^d n),e^{2\sqrt {dIn({n \mathord{\left/ {\vphantom {n {\sqrt d }}} \right. \kern-\nulldelimiterspace} {\sqrt d }})} + O(\sqrt d + Inn)} \}$$ time in the unit cost model (where we count the number of arithmetic operations on the numbers in the input); to be precise, the algorithm computes the lexicographically smallest nonnegative point satisfyingn given linear inequalities ind variables. The expectation is over the internal randomizations performed by the algorithm, and holds for any input. In conjunction with Clarkson's linear programming algorithm, this gives an expected bound of $$O(d^2 n + e^{O(\sqrt {dInd} )} ).$$ The algorithm is presented in an abstract framework, which facilitates its application to several other related problems like computing the smallest enclosing ball (smallest volume enclosing ellipsoid) ofn points ind-space, computing the distance of twon-vertex (orn-facet) polytopes ind-space, and others. The subexponential running time can also be established for some of these problems (this relies on some recent results due to Gärtner).     

Disjoint essential sets of implicates of a CQ Horn function

In this paper we study a class of CQ Horn functions introduced in Boros et al. (Ann Math Artif Intell 57(3–4):249–291, 2010). We prove that given a CQ Horn function f, the maximal number of pairwise disjoint essential sets of implicates of f equals the minimum number of clauses in a CNF representing f. In other words, we prove that the maximum number of pairwise disjoint essential sets of implicates of f constitutes a tight lower bound on the size (the number of clauses) of any CNF representation of f.     

Multiple spatial sounds in hierarchical menu navigation for visually impaired computer users

This paper describes a user study on the benefits and drawbacks of simultaneous spatial sounds in auditory interfaces for visually impaired and blind computer users. Two different auditory interfaces in spatial and non-spatial condition were proposed to represent the hierarchical menu structure of a simple word processing application. In the horizontal interface, the sound sources or the menu items were located in the horizontal plane on a virtual ring surrounding the user’s head, while the sound sources in the vertical interface were aligned one above the other in front of the user. In the vertical interface, the central pitch of the sound sources at different elevations was changed in order to improve the otherwise relatively low localization performance in the vertical dimension. The interaction with the interfaces was based on a standard computer keyboard for input and a pair of studio headphones for output. Twelve blind or visually impaired test subjects were asked to perform ten different word processing tasks within four experiment conditions. Task completion times, navigation performance, overall satisfaction and cognitive workload were evaluated. The initial hypothesis, i.e. that the spatial auditory interfaces with multiple simultaneous sounds should prove to be faster and more efficient than non-spatial ones, was not confirmed. On the contrary—spatial auditory interfaces proved to be significantly slower due to the high cognitive workload and temporal demand. The majority of users did in fact finish tasks with less navigation and key pressing; however, they required much more time. They reported the spatial auditory interfaces to be hard to use for a longer period of time due to the high temporal and mental demand, especially with regards to the comprehension of multiple simultaneous sounds. The comparison between the horizontal and vertical interface showed no significant differences between the two. It is important to point out that all participants were novice users of the system; therefore it is possible that the overall performance could change with a more extensive use of the interfaces and an increased number of trials or experiments sets. Our interviews with visually impaired and blind computer users showed that they are used to sharing their auditory channel in order to perform multiple simultaneous tasks such as listening to the radio, talking to somebody, using the computer, etc. As the perception of multiple simultaneous sounds requires the entire capacity of the auditory channel and total concentration of the listener, it does therefore not enable such multitasking.     

Nodes on ropes: a comprehensive data and control flow for steering ensemble simulations

Flood disasters are the most common natural risk and tremendous efforts are spent to improve their simulation and management. However, simulation-based investigation of actions that can be taken in case of flood emergencies is rarely done. This is in part due to the lack of a comprehensive framework which integrates and facilitates these efforts. In this paper, we tackle several problems which are related to steering a flood simulation. One issue is related to uncertainty. We need to account for uncertain knowledge about the environment, such as levee-breach locations. Furthermore, the steering process has to reveal how these uncertainties in the boundary conditions affect the confidence in the simulation outcome. Another important problem is that the simulation setup is often hidden in a black-box. We expose system internals and show that simulation steering can be comprehensible at the same time. This is important because the domain expert needs to be able to modify the simulation setup in order to include local knowledge and experience. In the proposed solution, users steer parameter studies through the World Lines interface to account for input uncertainties. The transport of steering information to the underlying data-flow components is handled by a novel meta-flow. The meta-flow is an extension to a standard data-flow network, comprising additional nodes and ropes to abstract parameter control. The meta-flow has a visual representation to inform the user about which control operations happen. Finally, we present the idea to use the data-flow diagram itself for visualizing steering information and simulation results. We discuss a case-study in collaboration with a domain expert who proposes different actions to protect a virtual city from imminent flooding. The key to choosing the best response strategy is the ability to compare different regions of the parameter space while retaining an understanding of what is happening inside the data-flow system.     

Multi-scale computational model for failure analysis of metal frames that includes softening and local buckling

In this work we present a new modelling paradigm for computing the complete failure of metal frames by combining the stress-resultant beam model and the shell model. The shell model is used to compute the material parameters that are needed by an inelastic stress-resultant beam model; therefore, we consider the shell model as the meso-scale model and the beam model as the macro-scale model. The shell model takes into account elastoplasticity with strain-hardening and strain-softening, as well as geometrical nonlinearity (including local buckling of a part of a beam). By using results of the shell model, the stress-resultant inelastic beam model is derived that takes into account elastoplasticity with hardening, as well as softening effects (of material and geometric type). The beam softening effects are numerically modelled in a localized failure point by using beam finite element with embedded discontinuity. The original feature of the proposed multi-scale (i.e. shell-beam) computational model is its ability to incorporate both material and geometrical instability contributions into the stress-resultant beam model softening response. Several representative numerical simulations are presented to illustrate a very satisfying performance of the proposed approach.