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991.
Sara Garcinuo Francisco Javier Gil-Etayo Esther Mancebo Marta Lpez-Nevado Antonio Lalueza Raquel Díaz-Simn Daniel Enrique Pleguezuelo Manuel Serrano Oscar Cabrera-Marante Luis M. Allende Estela Paz-Artal Antonio Serrano 《International journal of molecular sciences》2022,23(12)
NK degranulation plays an important role in the cytotoxic activity of innate immunity in the clearance of intracellular infections and is an important factor in the outcome of the disease. This work has studied NK degranulation and innate immunological profiles and functionalities in COVID-19 patients and its association with the severity of the disease. A prospective observational study with 99 COVID-19 patients was conducted. Patients were grouped according to hospital requirements and severity. Innate immune cell subpopulations and functionalities were analyzed. The profile and functionality of innate immune cells differ between healthy controls and severe patients; CD56dim NK cells increased and MAIT cells and NK degranulation rates decreased in the COVID-19 subjects. Higher degranulation rates were observed in the non-severe patients and in the healthy controls compared to the severe patients. Benign forms of the disease had a higher granzymeA/granzymeB ratio than complex forms. In a multivariate analysis, the degranulation capacity resulted in a protective factor against severe forms of the disease (OR: 0.86), whereas the permanent expression of NKG2D in NKT cells was an independent risk factor (OR: 3.81; AUC: 0.84). In conclusion, a prompt and efficient degranulation functionality in the early stages of infection could be used as a tool to identify patients who will have a better evolution. 相似文献
992.
993.
Pieter Geiregat Carmelita Rodá Ivo Tanghe Shalini Singh Alessio Di Giacomo Delphine Lebrun Gianluca Grimaldi Jorick Maes Dries Van Thourhout Iwan Moreels Arjan J.Houtepen Zeger Hens 《光:科学与应用(英文版)》2021,10(6):1122-1132
2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton tra... 相似文献
994.
G. Marin S. M. Wasim G. Sánchez Pérez P. Bocaranda A. E. Mora 《Journal of Electronic Materials》1998,27(12):1351-1357
A new method to grow single crystals with stoichiometry close to 1:1:2 of CuInTe2, an important member of the Cu-III-VI2 family of semiconductors is described. This consists of tellurization in the liquid phase of stoichiometric Cu and In and
later solidification under directional freezing. It is found from energy dispersive spectroscopy that the ingots obtained
with the evaporation temperature (Tt) of Te at 590 and 635°C were very close to the ideal stoichiometry 1:1:2. Samples of all ingots obtained with Tt between 530 and 690°C, as studied by x-ray and differential thermal analysis, were of single phase having chalcopyrite structure
and p-type conductivity. Optical and electrical characterization of different ingots were made. The acceptor ionization energy
EA and the density of states effective mass m
p
*
of the holes are estimated from the temperature dependence of the hole concentration p in samples of different ingots. m
p
*
= (0.78 ± 0.02) me agrees quite well with the reported value. From a combined analysis of the variation of EA with p1/3 and the knowledge of molecularity and valence stoichiometry of each sample, it is established that the shallow acceptor level
observed in different samples with EA (0) ⋍ 30 meV is due to VIn. 相似文献
995.
Octávio P. Dias Isabel C. Teixeira J. Paulo Teixeira 《Journal of Electronic Testing》1999,14(1-2):149-158
The purpose of this paper is to present a novel methodology for assessing the quality of architecture solutions of hw/sw systems, with particular emphasis on testability. Criteria and metrics for quality assessment are proposed and used to assist the design team in selecting a best-fitted architecture that satisfies not only functional requirements, but also test requirements. The methodology makes use of object-oriented modeling techniques. Near-optimum clustering of methods and attributes into objects is carried out, in such a way that objects with moderate complexity, low coupling and high functional autonomy, result. The main features of the methodology are ascertained through a case study. 相似文献
996.
997.
Antonio Sánchez‐Díaz Marta Izquierdo Salvatore Filippone Nazario Martin Emilio Palomares 《Advanced functional materials》2010,20(16):2695-2700
Organic solar cells made using a blend of DPM12 and P3HT are studied. The results show that higher Voc can be obtained when using DPM12 in comparison to the usual mono‐substituted PCBM electron acceptor. Moreover, better device performances are also registered when the cells are irradiated with sun‐simulated light of 10–50 mW cm?2 intensity. Electrochemical and time‐resolved spectroscopic measurements are compared for both devices and a 100‐mV shift in the density of states (DOS) is observed for DPM12/P3HT devices with respect to PCBM/P3HT solar cells and slow polaron‐recombination dynamics are found for the DPM12/P3HT devices. These observations can be directly correlated with the observed increase in Voc, which is in contrast with previous results that correlated the higher Voc with different ideality factors obtained using dark‐diode measurements. The origin for the shift in the DOS can be correlated to the crystallinity of the blend that is influenced by the properties of the included fullerene. 相似文献
998.
Chloride and Indium‐Chloride‐Complex Inorganic Ligands for Efficient Stabilization of Nanocrystals in Solution and Doping of Nanocrystal Solids 下载免费PDF全文
Vladimir Sayevich Chris Guhrenz Maria Sin Volodymyr M. Dzhagan Alexander Weiz Daniel Kasemann Eike Brunner Michael Ruck Dietrich R. T. Zahn Karl Leo Nikolai Gaponik Alexander Eychmüller 《Advanced functional materials》2016,26(13):2163-2175
Here, the surface functionalization of CdSe and CdSe/CdS core/shell nanocrystals (NCs) with compact chloride and indium‐chloride‐complex ligands is reported. The ligands provide not only short interparticle distances but additionally control doping and passivation of surface trap states, leading to enhanced electronic coupling in NC‐based arrays. The solids based on these NCs show an excellent electronic transport behavior after heat treatment at the relatively low temperature of 190 °C. Indeed, the indium‐chlorido‐capped 4.5 nm CdSe NC based thin‐film field‐effect transistor reaches a saturation mobility of μ = 4.1 cm2 (V s)?1 accompanied by a low hysteresis, while retaining the typical features of strongly quantum confined semiconductor NCs. The capping with chloride ions preserves the high photoluminescence quantum yield ( ≈ 66%) of CdSe/CdS core/shell NCs even when the CdS shell is relatively thin (six monolayers). The simplicity of the chemical incorporation of chlorine and indium species via solution ligand exchange, the efficient electronic passivation of the NC surface, as well as their high stability as dispersions make these materials especially attractive for wide‐area solution‐processable fabrication of NC‐based devices. 相似文献
999.
Daniel H. Mendelsohn Katja Schnabel Andreas Mamilos Samuel Sossalla Steffen Pabel Georg Daniel Duerr Karsten Keller Volker H. Schmitt Friedrich Barsch Nike Walter Ronald Man Yeung Wong Thaqif El Khassawna Tanja Niedermair Volker Alt Markus Rupp Christoph Brochhausen 《International journal of molecular sciences》2022,23(9)
Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options. However, the majority of recent studies are performed in highly energy-dependent tissues, such as cardiac, hepatic, and neuronal tissues. In contrast, publications on mitochondrial dynamics from the orthopedic or trauma fields are quite rare, even if there are common cellular mechanisms in cardiovascular and bone tissue, especially regarding bone infection. The present report summarizes the spectrum of mitochondrial alterations in the cardiovascular system and compares it to the state of knowledge in the musculoskeletal system. The present paper summarizes recent knowledge regarding mitochondrial dynamics and gives a short, but not exhaustive, overview of its regulation via fission and fusion. Furthermore, the article highlights hypoxia and its accompanying increased mitochondrial fission as a possible link between cardiac ischemia and inflammatory diseases of the bone, such as osteomyelitis. This opens new innovative perspectives not only for the understanding of cellular pathomechanisms in osteomyelitis but also for potential new treatment options. 相似文献
1000.
Lorenzo Landini Daniel Souza Monteiro de Araujo Mustafa Titiz Pierangelo Geppetti Romina Nassini Francesco De Logu 《International journal of molecular sciences》2022,23(9)
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized in a subpopulation of primary sensory neurons of the trigeminal, vagal, and dorsal root ganglia, where its activation mediates neurogenic inflammatory responses. TRPA1 expression in resident tissue cells, inflammatory, and immune cells, through the indirect modulation of a large series of intracellular pathways, orchestrates a range of cellular processes, such as cytokine production, cell differentiation, and cytotoxicity. Therefore, the TRPA1 pathway has been proposed as a protective mechanism to detect and respond to harmful agents in various pathological conditions, including several inflammatory diseases. Specific attention has been paid to TRPA1 contribution to the transition of inflammation and immune responses from an early defensive response to a chronic pathological condition. In this view, TRPA1 antagonists may be regarded as beneficial tools for the treatment of inflammatory conditions. 相似文献