A quantitative analysis of the effectiveness of laparascopy and endoscopy virtual reality simulators

The increasing use of virtual reality (VR) simulators in surgical training makes it imperative that definitive studies be performed to assess their training effectiveness. Indeed in this paper we report the meta-analysis of the efficacy of virtual reality simulators in (1) the transference of skills from the simulator training environment to the operating room and (2) their ability to discriminate between the experience levels of its users. The task completion time and the error score were the two study outcomes collated and analyzed in this meta-analysis. Sixteen studies were identified from a computer-based literature search (1996-2004). The meta-analysis of the random-effects model (because of the heterogeneity of the data) revealed that training on virtual reality simulators did lessen the time taken to complete a given surgical task as also clearly differentiate between the experienced and the novice trainees. Meta-analytic studies such as the one reported here would be very helpful in the planning and setting up of surgical training programs and for the establishment of reference ‘learning curves’ for a specific simulator and surgical task. If any such programs already exist they can then indicate the improvements to be made in the simulator used such as providing for more variety in their case scenarios based on the state and/or rate of learning of the trainee.     

Determination of optimal feedback terminal controllers for general boundary conditions using generating functions

Given a nonlinear system and a performance index to be minimized, we present a general approach to expressing the finite time optimal feedback control law applicable to different types of boundary conditions. Starting from the necessary conditions for optimality represented by a Hamiltonian system, we solve the Hamilton-Jacobi equation for a generating function for a specific canonical transformation. This enables us to obtain the optimal feedback control for fundamentally different sets of boundary conditions only using a series of algebraic manipulations and partial differentiations. Furthermore, the proposed approach reveals an insight that the optimal cost functions for a given dynamical system can be decomposed into a single generating function that is only a function of the dynamics plus a term representing the boundary conditions. This result is formalized as a theorem. The whole procedure provides an advantage over methods rooted in dynamic programming, which require one to solve the Hamilton-Jacobi-Bellman equation repetitively for each type of boundary condition. The cost of this favorable versatility is doubling the dimension of the partial differential equation to be solved.     

Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers

Poly(ethylene oxide) (PEO) oligomers are employed extensively in pharmaceutical and biomedical arenas mainly due to their excellent physical and biological properties, including solubility in water and organic solvents, lack of toxicity, and absence of immunogenicity. PEO can be chemically modified and reacted with, or adsorbed onto, other molecules and surfaces. Sophisticated applications for PEO have increased the demand for PEO oligomers with tailored functionalities, and heterobifunctional PEOs are often needed. This review discusses the synthesis and applications of heterobifunctional PEO oligomers possessing amine, carboxylate, thiol, and maleimide functional groups.     

Nondegradative microextrusion of resorbable polyesters for pharmaceutical and biomedical applications: The cases of poly‐lactic‐acid and poly‐caprolactone

In recent years biodegradable polymers, particularly polyesters such as the poly(lactic acid) (PLA) and polycaprolactone (PCL), have gained high interests for their applicability in the biomedical and pharmaceutical fields where they're used for manufacturing various different resorbable devices, from tissue engineering scaffolds to controlled drug release systems. Despite many positive characteristics, processability of these materials still remains a critical issue as they easily tend to degrade during manufacturing. In this article we aimed to assess microextrusion as a nondegradative process for manufacturing PLA and PCL. The results we experimentally obtained, that are hereby presented, set a new point in the on‐going debate on degradation during processing of resorbable polymers as they allow to affirm that microextrusion leaves unmodified molecular weight distributions without producing any evident reductions in mean molecular weight. Microextrusion thus represents a risk‐free high molecular weight polymer processing solution for obtaining nondegraded products within pharmaceutical and biomedical production lines, such as for scaffolds for tissue engineering applications or drug delivery. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Plasma power can make better powders

It may be a truism to say that round powders pack better, but spheroidisation of powder particles is one of the successful commercial applications of induction plasma technology and can play a key role in substantial improvement of powder quality and fluidity…     

Treatment of aggression for an adult diagnosed with schizophrenia at a public psychiatric hospital.

The effectiveness of a behavioral program to treat chronic aggression in an adult male individual diagnosed with schizophrenia at a public psychiatric hospital was evaluated. A behavioral plan was developed to provide the client with positive social interactions, social skills training, and positive reinforcement for prosocial behavior; no negative consequences were implemented. The number of aggressive acts declined with the introduction of the behavioral plan and ultimately remitted even without ongoing reinforcers. This article demonstrates the value of psychological intervention in treating aggression with a treatment-resistant client in an in-patient setting. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Parametric circles and spheres

Formulations for parametric circles and spheres in terms of rational Gaussian (RaG) curves and surfaces are introduced. With the proposed formulations, a full circle is generated by interpolating a closed RaG curve to the vertices of an equilateral triangle, and a full sphere is generated by interpolating a closed RaG surface to the vertices of an octahedron with equilateral triangular faces. Generation of circles and spheres in this manner is very intuitive and easy to remember as the weights are all 1 and the nodes are all unique and uniformly spaced.