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61.
Magnetic particle imaging (MPI) uses safe iron oxide nanoparticle tracers to offer fundamentally new capabilities for medical imaging, in applications as vascular imaging and ultra-sensitive cancer therapeutics. MPI is perhaps the first medical imaging platform to intrinsically exploit nanoscale material properties. MPI tracers contain magnetic nanoparticles whose tunable, size-dependent magnetic properties can be optimized by selecting a particular particle size and narrow size-distribution. In this paper we present experimental MPI measurements acquired using a homemade MPI magnetometer: a zero-dimensional MPI imaging system designed to characterize tracer performance by measuring the derivative of the time-varying tracer magnetization, M'(H(t)), at a driving frequency of 25 kHz. We show that MPI performance is optimized by selecting phase-pure magnetite tracers of a particular size and narrow size distribution; in this work, tracers with 20 nm median diameter, log-normal distribution shape parameter, σ(v), equal to 0.26, and hydrodynamic diameter equal to 30 nm showed the best performance. Furthermore, these optimized MPI tracers show 4?×?greater signal intensity (measured at the third harmonic) and 20% better spatial resolution compared with commercial nanoparticles developed for MRI. 相似文献
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J. D. Watson J. D. Allen C. A. Mattson S. M. Ferguson 《Structural and Multidisciplinary Optimization》2016,53(6):1277-1294
System evolvability is vital to the longevity of large-scale complex engineered systems. The need for evolvability in complex systems is a result of their long service lives, rapid advances to their integrated technologies, unforeseen operating conditions, and emerging system requirements. Building excess capability into complex systems can improve their ability to evolve while in service. However, excess capability increases initial build cost and operating cost, which is compounded across the service life of the system. Excess capability that is eventually used adds benefit by allowing for in-service evolution to meet emerging system requirements. Therefore, there is a trade-off between the cost of excess capability initially built into the system and the benefit that is added to the system by enabling future evolution. This paper introduces a process for optimizing the amount of excess capability in a complex system. This process results in a set of evolvable systems without excessive cost. We demonstrate how this process can be used to select the amount of excess capability that should be included in a military ground vehicle. 相似文献
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Janet M. Ferguson Jeffrey P. Dorman 《Canadian Journal of Science, Mathematics, & Technology Education》2013,13(3):323-331
Abstract The strongest tradition of classroom‐environment research has focused on empirically testing the relationship between the classroom environment and student outcomes. This paper reports a study conducted within this general framework. Specifically, this research investigated the relationship between the classroom environment and self‐handicapping by students in Canadian high school mathematics classes. Results showed that the classroom environment accounted for appreciable proportions of variance in self‐handicapping, beyond that attributable to academic efficacy. Enhanced affective dimensions of the classroom environment were associated with reduced levels of self‐handicapping. 相似文献
65.
Despite decades of research, no scholarly consensus has been achieved regarding the potential impact of video games on youth aggression or other public health concerns. In recent years, hypotheses have been raised that scholarly opinions on video games may resemble past moral panics, with attitudes reflective of generational conflicts. These hypotheses are tested in a sample of 175 criminologists, psychologists, and media scholars, examining both overall negative attitudes about video games and perceived linkages with youth assaults specifically. Results reflected continued lack of scholarly consensus on the issue of video game influences with only 15.3% of scholars endorsing the view that violent video games contribute to youth assaults. As hypothesized, older scholars endorsed more negative views of video games generally, although this appeared to be related to experience with games rather than age per se. Scholars with more negative attitudes toward youth themselves were also more negative about games. Criminologists and media scholars were more skeptical of violent video games contributing to youth assaults than were psychologists. These results are discussed in relation to Moral Panic Theory. 相似文献
66.
In this paper, we demonstrated the processing of Li7La3Zr0.5Nb0.5Ta0.5Hf0.5O12 (LLZNTH) high-entropy Li–garnet with promising properties for lithium batteries. We first synthesized the LLZNTH Li–garnet powders which have a single cubic garnet phase (space group: ; No. 230) without any secondary phases as well as uniform elements distributions. The prepared powders were further densified to a relative density of ∼94% with well-crystallized grains and good contact with the neighboring grains. Minimal grain growth can be observed in the sintering time range from 8 to 20 h, which is likely due to the sluggish effects of high-entropy compounds. The sample also maintains the cubic garnet phase along with uniform elements distribution after sintering. Electrochemical characterizations indicate that the densified sample has an adequate ionic conductivity of 4.67 × 10−4 S cm−1 at room temperature, a low activation energy of 0.25 eV, and a low electronic conductivity in the order of 10−8 S cm−1. The significance of designing high-entropy electrolyte is further discussed. 相似文献
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J. B. Ferguson Benjamin F. Schultz Pradeep K. Rohatgi Chang-Soo Kim 《Metals and Materials International》2014,20(4):747-755
Understanding the settling behavior of nanoparticles in molten metals/alloys is important as it will aid in achieving uniform dispersions of reinforcement particles in metal matrix nanocomposites. Uniform dispersions are necessary to activate the Orowan strengthening mechanism, which can increase yield strength without significant diminishment of ductility. In this work, an analytical model of particle size effects on settling is described that takes into account both deterministic Stokes’ law and stochastic Brownian motion. The model shows a clear transitional behavior where settling velocity follows Stokes’ law for large particles and then drops to zero for small particles implying that Brownian motion predominates. It indicated that, in the Brownian motion regime, where the discrete nature of the liquid must be considered, the random motion imparted by unbalanced collisions can overwhelm the motions normally imposed by forces such as gravity, viscous drag, and thermal/concentration gradients. 相似文献