Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco-2 cell line model

Previous work showed that the bioavailability of fluoride in dark tea was lower than NaF solution. However, limited information is available indicating the effects of tea components on the fluoride bioavailability. In this study, the effects of the components in tea on the bioavailability of fluoride were evaluated in the Caco-2 cell line model. Additionally, the mechanism of effect of aluminium on fluoride transport was investigated. The result showed that 10–100 μm of epigallocatechin gallate (EGCG) could not influence fluoride transport. Al³⁺ significantly decreased fluoride transport in both apical-basolateral and basolateral-apical directions. Moreover, aluminium could form different forms of aluminium fluoride complexes, which were transported through Caco-2 cells by different pathways. F⁻ transport was mainly dependent on the paracellular pathway and active transport involving Cl⁻ channels. The paracellular pathway played a predominant role in transport of AlF₃. The paracellular pathway and active transport both participated in AlF₂⁺ transport.     

脱脂大豆粕硫酸酸解试验和利用

选择脱脂大豆粕硫酸酸解条件,底物浓度20％,5％的硫酸加酸量为1:5,酸解温度80℃,酸解时间8h,作酸解试验,可获得氨基酸含量(0.91g/100ml)、还原糖含量(8.7g/100ml)、可溶性固形物含量(20g/100ml)都较高的酸解液;利用酸解液调配酱油、饮料;利用粕渣粉作贫蛋白食品添加剂,蛋白质饲料,具有可行性并有很好的效益。     

A HiPAD Integrated with rGO/MWCNTs Nano-Circuit Heater for Visual Point-of-Care Testing of SARS-CoV-2

Nowadays, the main obstacle for further miniaturization and integration of nucleic acids point-of-care testing devices is the lack of low-cost and high-performance heating materials for supporting reliable nucleic acids amplification. Herein, reduced graphene oxide hybridized multi-walled carbon nanotubes nano-circuit integrated into an ingenious paper-based heater is developed, which is integrated into a paper-based analytical device (named HiPAD). The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still raging across the world. As a proof of concept, the HiPAD is utilized to visually detect the SARS-CoV-2 N gene using colored loop-mediated isothermal amplification reaction. This HiPAD costing a few dollars has comparable detection performance to traditional nucleic acids amplifier costing thousands of dollars. The detection range is from 25 to 2.5 × 10¹⁰ copies mL⁻¹ in 45 min. The detection limit of 25 copies mL⁻¹ is 40 times more sensitive than 1000 copies mL⁻¹ in conventional real-time PCR instruments. The disposable paper-based chip could also avoid potential secondary transmission of COVID-19 by convenient incineration to guarantee biosafety. The HiPAD or easily expanded M-HiPAD (for multiplex detection) has great potential for pathogen diagnostics in resource-limited settings.     

城市煤气甲烷化低镍催化剂的研究

使用活性评价装置和TPR、XRD、TEM等技术研究了活性组分Ni含量和助剂MgO、La_2O_3、MnO_2对 Ni 基城市煤气甲烷化催化剂性能的影响。结果表明 NiO 的含量可以在较大范围内变化,最低允许含量为6%(wt),MgO 与 NiO 能形成MgNiO_2,它的形成提高了催化剂的热稳定性。随 MgO 含量的增加热稳定性能增强,而且 MgO 含量影响催化剂表面酸度和积碳迷度,当其含量为1%(wt)时,催化剂无积碳出现。La_2O_3不与其它组分发生化学作用,稳定地分散于载体表面,可起到均化 Ni 晶粒度作用,它的存在对催化剂的活性和还原性能均有影响。实验研究出一种 Ni 含量低、活性高、热稳定性好、抗积碳能力强的城市煤气甲烷化催化剂。     

聚碳硅烷纤维在环己烯气氛中的不熔化处理

将聚碳硅烷(PCS)纤维在环己烯气氛中进行化学气相交联不熔化处理,其氧含量比空气不熔化处理大大降低,组成和结构也发生了变化,气体副产物中存在环己烷和小分子硅烷.在环己烯气氛中,随着温度的升高,PCS分子的Si-H键的反应程度逐渐提高,纤维的凝胶含量逐渐增大.环己烯受热引发PCS分子中的Si-H和Si-CH3键断裂生成Si自由基和Si-CH2自由基,促进PCS分子间形成Si-CH2-Si交联结构;同时,环己烷作为侧基引入到PCS分子结构中,使纤维的碳含量随之增高.随着反应温度的升高,部分环己烷侧基和少量小分子硅烷会从PCS分子主链脱出.     

R11 peptides can promote the molecular imaging of spherical nucleic acids for bladder cancer margin identification

One of the critical problems in bladder cancer(BC)management is the local recurrence of disease.However,achieving the accurate delineation of tumor margins intr...     

Direct Imaging of Antiferromagnet-Ferromagnet Phase Transition in van der Waals Antiferromagnet CrSBr

The advent of van der Waals (vdW) ferromagnetic (FM) and antiferromagnetic (AFM) materials offers unprecedented opportunities for spintronics and magneto-optic devices. Combining magnetic Kerr microscopy and density functional theory calculations, the AFM-FM transition is investigated and a surprising abnormal magneto-optic anisotropy in vdW CrSBr associated with different magnetic phases (FM, AFM, or paramagnetic state) is discovered. This unique magneto-optic property leads to different anisotropic optical reflectivity from different magnetic states, permitting direct imaging of the AFM Néel vector orientation and the dynamic process of the AFM-FM transition within a magnetic field. Using Kerr microscopy, not only the domain nucleation and propagation process is imaged but also the intermediate spin-flop state in the AFM-FM transition is identified. The unique magneto-optic property and clear identification of the dynamics process of the AFM-FM phase transition in CrSBr demonstrate the promise of vdW magnetic materials for future spintronic technology.     

基于谱残差和多分辨率分析的显著目标检测

根据人类视觉系统的特点,提出一种融合谱残差和多分辨率分析的显著目标检测方法。该方法通过在不同尺度上计算图像的亮度、颜色以及方向特征的谱残差,构建多分辨率显著性图谱序列,然后用线性插值方法将不同分辨率的特征显著图叠加得到3个特征显著图,再利用k均值聚类算法将每个特征显著图聚为两类,选择聚类中心距离最大的特征显著图作为最终的显著图,最后经过动态阈值处理获得图像的显著目标区域。基于自然图像的显著目标检测实验结果表明,该方法具有较强的稳定性和实用性,得到较为满意的检测结果。     

集成模糊LSA与MIL的图像分类算法

针对自然图像的分类问题,提出一种基于模糊潜在语义分析(LSA)与直推式支持向量机(TSVM)相结合的半监督多示例学习(MIL)算法.该算法将图像当作多示例包,分割区域的底层视觉特征当作包中的示例.为了将MIL问题转化成单示例问题进行求解,首先利用K-Means方法对训练包中所有的示例进行聚类,建立"视觉词汇表";然后根据"视觉字"与示例之间的距离定义模糊隶属度函数,建立模糊"词-文档"矩阵,再采用LSA方法获得多示例包(图像)的模糊潜在语义模型,并通过该模型将每个多示例包转化成单个样本;采用半监督的TSVM训练分类器,以利用未标注图像来提高分类精度.基于Corel图像库的对比实验结果表明,与传统的LSA方法相比,模糊LSA的分类准确率提高了5.6%,且性能优于其他分类方法.     

杂环化合物在农药发展中的重要作用

在近年的农药发展中，杂环化合物农药是重要的发展趋向，而在杂环化合物中，含氨杂环化合物则是新农药发展的热点，在含氮杂环化合物中，含有吡啶，嘧啶，吡唑，三唑等杂环和稠杂环的化合物，又是发展最快，最为重要的领域，在这些领域中，出现了许多超高效的新品种，在今后的发展中，出现了许多超高效的新品种，在今后的发展中，可望出现超高效，无公害农药的新纪元。