Comparative study of fuelwood consumption by villagers and seasonal “Dhaba owners” in the tourist affected regions of Garhwal Himalaya,India

The rural inhabitants of the Himalayan region have been exploiting forest resources for their livelihood for generations. The excessive and uncontrolled use of firewood for domestic purposes has ended up with severe deforestation. Therefore, quantification, assessment and restoration of such valuable but exhaustible resources and is imperative their scientific management. The estimates reflect that a total of 88 species are consumed as fuelwood (54 trees and 34 shrubs) by the local people. Fuelwood consumption by ‘dhaba’ (roadside refreshment establishments) owners (90–120 kg/household/day) was much higher over the common villagers (20–22 kg/household/day). The fuelwood is mainly burnt for cooking, water heating, space heating and lighting, etc. Among these, cooking consumes the fuelwood most. In addition, fuelwood demand increases due to influx of tourists. In the near future, this may also affect the status of the undisturbed forests at the middle elevation. The information in this communication could be utilized for developing various conservation and sustainable strategies in the region to mitigate the impact of forest resource for fodder and fuelwood.     

Transparent, luminescent, antibacterial and patternable film forming composites of graphene oxide/reduced graphene oxide

Multifunctional graphene oxide/reduced graphene oxide (GO/RGO) composites were prepared through electrostatic interaction using biocompatible ingredients. Different functionalities were added to GO/RGO by anchoring materials such as native lactoferrin (NLf), NLf protected Au clusters (designated as Au@NLf), chitosan (Ch) and combinations thereof. Anchoring of Ch and NLf enhances the antibacterial property of RGO/GO. The addition of Ch to RGO/GO not only helped in forming stable dispersions but also helped in fabricating large (cm(2)) area films through a simple solvent evaporation technique. Functionalities such as photoluminescence were added to Ch-RGO/GO composites by anchoring Au@NLf on it. The composites thus formed showed stable luminescence in presence of various metal ions in the solid state. The composite showed reasonable stability against pH and temperature variations as well. The as-prepared films were transparent and the transparency could be modulated by controlling the concentration of RGO/GO in the composite. The antibacterial property and ability to form stable thin films may provide an opportunity to use such composites for medical and environmental remediation applications as well. Erasable patterns were fabricated on the film by stamping required patterns under compressive pressure. Luminescent patterns can be inscribed on the film and can be erased by simply wetting it. Such films with erasable information may be useful for security applications.     

Structural characterization of alpha methyl styrene‐butyl acrylate‐grafted polyetheretherketone films

Radiation‐induced graft copolymerization of alpha methyl styrene (AMS)‐butyl acrylate (BA) mixture onto poly(etheretherketone) (PEEK) was carried out to develop films of varying copolymer compositions. The characterization of films was carried out with fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), X‐ray diffraction analysis (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The presence of AMS and BA units within the film matrix was confirmed by FTIR. The intensity of the characteristic peaks for AMS and BA increased with the increasing grafted component in the films. The crystallinity of the films as observed from DSC and XRD decreased with the increasing graft levels. On the other hand, the melting temperature of the base polymer was almost unaffected by irradiation and the grafting process. The glass transition temperature (T_g) of the grafted film increased as compared to the virgin PEEK. Ungrafted film showed a stable thermogram up to ～500°C. However, the grafting introduced a new decomposition range in the copolymer, due to the presence of the AMS/BA. AFM images showed the formation of domains on the grafted PEEK film surface. The SEM also showed domain formation of the grafted component within the PEEK matrix. However, the fracture analysis did not show any prominent phase separation. Mechanical characterization of films in terms of tensile strength, elongation, and modulus was also carried out. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013     

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression. The Food and Drug Administration has approved drugs (e.g., rivastigmine, donepezil, galantamine, and memantine) that at best provide marginal benefits, thus emphasizing the urgent need to explore other molecular entities as future drug candidates for AD. Looking at the wide pharmaceutical applications of heterocyclic compounds and particularly those containing benzofuran and indole ring systems, these molecular frameworks have drawn special attention from medicinal chemists for further evaluation in numerous diseases. This article focuses on the history and recent advances of benzofuran‐ and indole‐based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, γ‐secretase, β‐secretase, tau misfolding, and β‐amyloid aggregation.     

Structural parameters identification of uncertain multi-storey shear buildings using fuzzy neural network modelling

Present paper proposes a fuzzy neural network (FNN)-based modelling for the identification of structural parameters of uncertain multi-storey shear buildings. Here, the method is developed to identify uncertain structural mass, stiffness and damping matrices from the dynamic responses of the structure without any optimization processes that are generally used to solve inverse vibration problems. Uncertainty has been taken in term of fuzzy numbers. The governing equations of motion are first solved by the classical method to get responses of the consecutive stories. Further the governing equations of motion are modified based on relative responses of consecutive stories in such a way that the new set of equations can be implemented in a cluster of FNNs. As such the model starts solving the nth floor by FNN modelling to estimate the structural parameters. Subsequently, series of FNN models are used to estimate the parameters for (n ? 1)th storey to the first storey. One may note that single layer FNNs have been used for training for each cluster of the FNN such that the converged weights give the uncertain structural parameters. The initial weights in the FNN architecture are taken as the design parameters in uncertain (fuzzy) form. In order to validate the present model, various example problems of different multi-storey shear structures have been considered. Related results are incorporated in term of tables and graphs. Comparisons between theoretical and identified results are carried out and are found to be in good agreement.     

Investigation of Anti-Cancer Drug Nimustine Interaction with Calf Thymus DNA

Nimustine, a chloroethyl nitrosourea derivative (CENU), is an antineoplastic agent, which is used for the treatment of various types of cancer. The present study focuses on the prediction and investigation of binding properties of nimustine with DNA using molecular modeling and UV–Visible spectroscopic technique. The docking study show that nimustine plausibly binds within the major groove of DNA. Further analysis of docking suggests direct interaction of nimustine with the moieties of heterocyclic nitrogenous bases of DNA. The free binding energy value of the best nimustine-DNA docked conformer is predicted as ?4.31 kcal/mol using docking results.The molecular modeling study also reveals that the interaction between nimustine and DNA is majorly governed by van der Waals forces, hydrogen bonding and hydrophobic interactions, whereas the contribution of electrostatic forces stands negligible. Further, UV–Visible spectra of free calf thymus DNA and its complexes with varying concentration of nimustine indicate the binding constant (K _a ) value as 3.27 × 10³ M^?1, which suggests moderate interaction of nimustine with DNA. The spectroscopic results are further used to calculate the binding free energy of the complex using the relation ΔG = ?RT ln (K _a ). This accounts for a value of ?4.79 kcal/mol. It corroborates well with the docking outcomes. The results of present study may help in designing and synthesis of new chloroethyl nitrosourea derivatives with improved efficacy and specificity for the target molecules.     

Nanoscale surface roughening of mulberry silk by monochromatic VUV excimer lamp

Surface treatment of mulberry silk was carried out using a VUV excimer lamp (172 nm). The changes occurring in morphology and physical properties of silk were studied. The nanopores created on the surface of treated samples were quantitatively analyzed using a high resolution scanning electron microscope. The physical and chemical changes taking place in silk fabric on irradiation were studied through measurement of wetting and wicking time, weight loss, crystallinity, and strength. Effect of irradiation time and distance from the lamp on these properties was also studied. Results show that wettability and wickability of silk improved significantly on exposure before stabilizing at 5 min irradiation time while the weight loss continued to increase. The effect of irradiation was negligible when the distance of the sample from the lamp became >15 mm. The effect of irradiation on tensile strength was found to be insignificant. Presence of moisture in silk hindered the effect of irradiation. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 4102–4106, 2007