Mechanical properties of a degradable phosphate glass fibre reinforced polymer composite for internal fracture fixation

This paper reports on the mechanical properties and pH upon degradation of phosphate glass fibre reinforced methacrylate-modified oligolactide. Phosphate glass fibres of the composition 51.04 P₂O₅–21.42 CaO–25.51 Na₂O–2.03 SiO₂ (mol%) were produced by a crucible spinning technique. Fibres were embedded into a matrix of a degradable organic polymer network based on methacrylate-modified oligolactide; samples with and without addition of CaCO₃ for pH control were produced. pH during degradation in physiological NaCl solution could be increased to up to 6.5 by addition of 20 wt.% calcium carbonate to the fibre composites. pH in Tris buffer solution was about 7.11. Mechanical properties of dry specimens were investigated during 3-point bending tests and gave elastic moduli in the range of cortical bone (15 to 20 GPa). However, addition of calcium carbonate decreased tensile strength of the fibre composites and resulted in brittle fracture behaviour, while CaCO₃-free composites showed a fibrous fracture mode. Control of pH and degradation is a requirement for obtaining a fracture fixation device with degradation properties matching in vivo requirements. Results show that addition of CaCO₃ is suitable for controlling the pH during degradation of metaphosphate glass polymer composites.     

Processed and prepared corn products as sources of lutein and zeaxanthin: compositional variation in the food chain

ABSTRACT:  Widely consumed by populations of all socioeconomic classes worldwide, corn is one of the few food sources of lutein and zeaxanthin. However, data on these carotenoids in processed corn and corn as eaten are lacking. Thus, the major carotenoids in the principal brands of processed corn (canned corn, corn meal, corn flour, corn flake) and in typical corn dishes (farofa, boiled corn, pamonha, curau, fried and boiled polenta) were determined. There was marked variation between processed products and between brands of the same product, but variation between lots of the same brand was small. Canned corn had the highest zeaxanthin (11.91 to 18.06 μg/g), β-cryptoxanthin (2.32 to 3.77 μg/g), and β-carotene (1.79 to 2.75 μg/g) contents. The corn flake breakfast cereal had the second highest amount of zeaxanthin (9.08 to 12.77 μg/g). Corn meal had the highest lutein (4.02 to 7.62 μg/g) level and also had good zeaxanthin content (6.13 to 11.39 μg/g), but drastic reduction of all carotenoids, especially zeaxanthin, occurred when it was toasted to farofa. Boiled corn also had lower carotenoid levels compared to the raw corn. The wide variations in carotenoid concentrations appeared to be due mainly to varietal differences in the carotenoid composition of raw materials and to losses during processing and preparation for consumption.     

Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells

Epithelial ovarian cancer (EOC) is the deadliest tumor among gynecological cancer in the industrialized countries. The EOC incidence and mortality have remained unchanged over the last 30 years, despite the progress in diagnosis and treatment. In order to develop novel and more effective therapeutic approaches, the molecular mechanisms involved in EOC progression have been thoroughly investigated in the last few decades. At the late stage, peritoneal metastases originate from the attachment of small clusters of cancer cells that shed from the primary site and carried by the ascites adhere to the abdominal peritoneum or omentum. This behavior suggests that cell–cell or cell–matrix adhesion mechanisms regulate EOC growth and dissemination. Complex downstream signalings, which might be influenced by functional cross-talk between adhesion molecules and co-expressed and activated signaling proteins, can affect the proliferation/survival and the migration/invasion of EOC cells. This review aimed to define the impact of the mechanisms of cell–cell, through cadherins, and cell–extracellular matrix adhesion, through integrins, on the signaling cascades induced by membrane receptors and cytoplasmic proteins known to have a role in the proliferation, migration and invasion of EOC cells. Finally, some novel approaches using peptidomimetic ligands to cadherin and integrins are summarized.     

Heating requirements in greenhouse farming in southern Italy: evaluation of ground-source heat pump utilization compared to traditional heating systems

Greenhouse farming, where energy consumptions are mainly related to the greenhouses heating, is one of the sectors consuming the most energy in the agricultural industry. High costs and the uncertain availability of fossil fuels constrain the use of heating applications. Among possible solutions, the utilization of renewable heating systems such as geothermal energy through ground-source heat pump systems (GSHPs) at competitive prices has to be taken in consideration. The competitiveness of these systems depends mainly on the characteristics of the end-users, i.e., the annual heating loads. Few studies focusing on the potential of using these systems start with an analysis of the thermal requirements and end with a cost evaluation in tune with local assets, geo-climatic conditions, and landscape protection. This paper analyzes the greenhouse crop industry in the Apulia region in southern Italy, as a potential end-user of GSHP systems. Data collected from an area mainly devoted to greenhouse crop production have been used to (a) describe greenhouse farms, (b) define the heating requirements of a greenhouse model representative of the most used typology in the investigated area, and (c) examine the economic viability of greenhouse heating with GSHP systems. Both vertical and horizontal ground heat exchanger (GHE) configurations are compared with conventional fossil-fuel heating systems. In all scenarios considered, the observed payback periods appear reasonable and worthy of consideration. The results suggest that these technologies can fully satisfy the winter heating requirements in a cost-effective way and they can support the planning of measures aimed to improve the sector competitiveness.     

Reversing roles: A cognitive strategy for undoing memory deficits associated with token status.

Tested whether having tokens (Ts) adopt the role of judge reduces cognitive deficits; examined several hypotheses to explain these deficits. In 3 experiments, Ss were asked to remember as many as possible of opinions exchanged in a group interaction with 3 actors. Experiment 1 demonstrated that judging majority members helped gender Ts improve their memory and ruled out self-denigration as a mediator of token deficits. Experiment 2 indicated that judging others was effective regardless of whether the others were said to know about it or not, ruling out insulation from evaluative scrutiny as a viable mediator for the judge role. Experiment 3 suggested the judge role restores completely the Ts' cognitive capacities and ruled out heightened responsibility as an explanation for the improved memory on judges. This work suggests that Ts may perform better if they can restructure cognitively their social environments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Low-dose nicotine nasal spray use and effects during initial smoking cessation.

The purposes of this study were to determine if smokers wanting to quit smoking would use a low-dose nicotine nasal spray (i.e., acceptability) and what effect this spray use would have on withdrawal during the 1st week of cessation. Smokers (n?=? 52) were assigned double-blind to either placebo or nicotine spray (1.5 μg/kg. or approx. 0.1 mg, per spray) for ad lib use during the first week of cessation. All received group behavioral counseling. There was no difference in continuous 1-week abstinence (daily COa?     

Differential expression of insulin-dependent diabetes mellitus-associated HLA-DQA1 alleles in vivo

The strong association of HLA-DQ genes with insulin-dependent diabetes mellitus (IDDM) susceptibility is persuasive evidence of their central role in the etiology of this autoimmune disease. Among other possibilities, it has been proposed that an unbalanced expression of IDDM-associated DQA, and/or DQB alleles may lead to alterations in the composition of alpha beta heterodimers and preferential expression of a particular heterodimer on the antigen-presenting cell surface, leading to self-recognition. In this report, we demonstrate the differential expression of DQA1 alleles in vivo, in particular of the two diabetogenic alleles DQA1*0301 and DQA1*0501. Family studies suggest that unequal HLA-DQA1 allele expression in heterozygous individuals is not associated in cis with the HLA-DQA1 gene, but may be affected by trans-acting determinant(s). We also discuss the segregation of this phenotype in IDDM-affected members. Furthermore, we examined historical samples of PBL from an IDDM-affected individual and an HLA-identical unaffected sibling acting in a kidney transplant program as donor and recipient, respectively. This analysis allowed us to establish that unbalanced expression of DQA1*0301 and DQA1*0501 can be induced by microenvironmental conditions. Inducible differential expression of HLA-DQA1 alleles may account for the discordance in the outcome of autoimmune disease in monozygotic twins and HLA-identical siblings.     

Inexpensive,rapid screening method for aflatoxins in peanuts and peanut products

Surveys of major Brazilian foodstuffs demonstrated that peanuts and peanut products continue to be very susceptible to aflatoxin contamination. To prevent, or at least minimise, the problem the aflatoxins need to be monitored by a rapid and inexpensive screening method. The AOAC Romer method has been used and found highly reliable. However, the clean-up step utilises anhydrous FeCl₃ and basic CuCO₃ which are expensive and not readily available in Brazil. Thus, the extraction (with a mixture of 270 ml methanol plus 30ml 40 g litre^?1 aqueous KCl) and clean-up (150 ml 100 g litre^?1 aqueous CuSO₄) steps of the method of Soares and Rodriguez-Amaya (1985) were combined with the AOAC minicolumn to provide a rapid, inexpensive screening technique. Fifty-two sample lots of peanuts and peanut products were screened by this and Romer's method, and the results were in complete agreement: 28 samples were negative, four < 20 μg kg^?1, 12 in the range 20–50 μg kg^?1, three in the range 50–100 μg kg^?1 and 5 >100 μg kg^?1. The results also agreed well when the extracts obtained by the two methods were submitted to quantitative TLC.     

灯泡党，节能灯开关瞬间消耗多少电能？

他们一边一本正经地告诫大小“盆”友们千万不能吞灯泡,一边又暗自得意地观望着是否有人不信邪。他们就是传说中神出鬼没的以折腾灯泡如此邪恶的活动为乐子的灯泡党!“吞灯泡门”之后,灯泡党名震江湖。今天,灯泡党重出江湖!还好,这一次,与邪恶无关。     

Reliability Model for Electronic Devices under Time Varying Voltage

Present reliability models, which estimate the lifetime of electronic devices, work under the assumption that the voltage level must be constant when an Accelerated Life Testing is performed. Nevertheless, in a real operational environment, electronic devices are subjected to electrical variations present in the power lines; that means the voltage has a time‐varying behavior, which breaks the assumption of reliability models. Thus, in this paper, a reliability model is presented, which describes the lifetime of electronic devices under time‐varying voltage via a parametric function. The model is based on the Cumulative Damage Model with random failure rate and the modified Inverse Power Law. In order to estimate the parameters of the proposed model, the maximum likelihood method was employed. A case study based on the time‐varying voltage induced by electrical harmonics when Alternate Current/Direct Current (AC/DC) transformer is connected to the power line is presented in this paper. Copyright © 2015 John Wiley & Sons, Ltd.